scholarly journals Evaluation of glutathione S-transferase P1 genetic variants affecting type-2 diabetes susceptibility and glycemic control

2012 ◽  
Vol 4 ◽  
pp. 631-636 ◽  
Author(s):  
Mahmoud A. Amer ◽  
Maivel H. Ghattas ◽  
Dina M. Abo-ElMatty ◽  
Soad H. Abou-El-Ela
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Genetic Variants ◽  
Glutathione S Transferase ◽  
Diabetes Susceptibility

Evaluation of glutathione S-transferase genetic variants affecting type 2 diabetes susceptibility: A meta-analysis

Gene ◽  
2013 ◽  
Vol 530 (2) ◽  
pp. 301-308 ◽  
Author(s):  
Song-tao Tang ◽  
Chang-jiang Wang ◽  
Hai-qin Tang ◽  
Qiu Zhang ◽  
Yuan Wang
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Meta Analysis ◽  
Glutathione S Transferase ◽  
Diabetes Susceptibility

scholarly journals Genetic variants of resistin and its plasma levels: Association with obesity and dyslipidemia related to type 2 diabetes susceptibility

Genomics ◽  
2019 ◽  
Vol 111 (4) ◽  
pp. 980-985 ◽  
Author(s):  
Nirali Rathwa ◽  
Roma Patel ◽  
Sayantani Pramanik Palit ◽  
A.V. Ramachandran ◽  
Rasheedunnisa Begum
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Plasma Levels ◽  
Diabetes Susceptibility

Replication of association between polymorphisms of the pancreatic ATP-sensitive potassium channel and susceptibility to type 2 diabetes in two Russian urban populations

2010 ◽  
Vol 5 (1) ◽  
pp. 67-77 ◽  
Author(s):  
Dimitry Chistiakov ◽  
Viktor Potapov ◽  
Dmitry Khodirev ◽  
Minara Shamkhalova ◽  
Marina Shestakova ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Katp Channel ◽  
Biochemical Parameters ◽  
Serum Insulin ◽  
Population Sample ◽  
Diabetic Patients ◽  
Diabetes Susceptibility ◽  
Risk Variant

AbstractThe KCNJ11 and ABCC8 genes encode components of the pancreatic ATP-sensitive potassium (KATP) channel. Previously, we reported association of the KCNJ11 E23K and ABCC8 R1273R G/A variants with type 2 diabetes (T2D) in a small Russian population sample (n=244). Here we replicated association between these genetic variants and T2D in a larger cohort (588 diabetic and 597 non-diabetic subjects). Using the ANCOVA analysis, Odds Ratios (ORs) and relationships between the carriage of a genotype and biochemical parameters of the patients were assessed and then adjusted for confounders (age, gender, HbA1c, hypertension, and obesity). The KCNJ11 K23 variant and the ABCC8 R1273R allele A showed association with higher risk of T2D (adjusted OR of 1.41 and 2.03, P<0.0001, respectively). Diabetic patients homozygous for K/K had lower 2h insulin (Padjusted=0.044). The ABCC8 A/A variant was associated with increased 2h serum insulin in diabetic and non-diabetic subjects (Padjusted=0.027 and 0.033, respectively). The carriage of the risk variant K/K of KCNJ11 E23K or A/A of ABCC8 G/A R1273R was associated with reduced response to nonsulfonylurea and sulfonylurea blockers of the pancreatic KATP channel. Adjusted attributable population risk was 3.0% (KCNJ11 E23K) and 4.8% (ABCC8 G/A) suggesting for the modest effects of these genetic variants on diabetes susceptibility.

scholarly journals Evaluation of the microsomal glutathione S-transferase 3 ( MGST3 ) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians

2003 ◽  
Vol 113 (4) ◽  
pp. 353-358 ◽  
Author(s):  
Farook Thameem ◽  
Xiaolin Yang ◽  
Paska A. Permana ◽  
Johanna K. Wolford ◽  
Clifton Bogardus ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Susceptibility Gene ◽  
Pima Indians ◽  
Glutathione S Transferase ◽  
Diabetes Susceptibility ◽  
Diabetes Susceptibility Gene ◽  
Microsomal Glutathione

Genetic variants of tumor necrosis factor-α and its levels: A correlation with dyslipidemia and type 2 diabetes susceptibility

2019 ◽  
Vol 38 (3) ◽  
pp. 1414-1422 ◽  
Author(s):  
Roma Patel ◽  
Sayantani Pramanik Palit ◽  
Nirali Rathwa ◽  
A.V. Ramachandran ◽  
Rasheedunnisa Begum
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Necrosis Factor ◽  
Genetic Variants ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Diabetes Susceptibility ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population

Diabetes ◽  
2015 ◽  
Vol 64 (7) ◽  
pp. 2646-2657 ◽  
Author(s):  
Robert L. Hanson ◽  
Rong Rong ◽  
Sayuko Kobes ◽  
Yunhua Li Muller ◽  
E. Jennifer Weil ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
American Indian ◽  
Genetic Variants ◽  
Indian Population ◽  
Diabetes Susceptibility ◽  
American Indian Population ◽  
High Prevalence
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