scholarly journals Evaluation of the placebo effect in the trials of allergen immunotherapy effectiveness: meta-analysis of randomized and placebo -controlled trials

2018 ◽  
Vol 35 (6) ◽  
pp. 620-625 ◽  
Author(s):  
Michał Abramowicz ◽  
Jerzy Kruszewski ◽  
Andrzej Chciałowski
Keyword(s):  
Placebo Effect ◽  
Allergen Immunotherapy ◽  
Meta Analysis ◽  
Controlled Trials

scholarly journals The Long-Lasting Effects of “Placebo Injections” in Knee Osteoarthritis: A Meta-Analysis

Cartilage ◽  
2020 ◽  
pp. 194760352090659 ◽  
Author(s):  
Davide Previtali ◽  
Giulia Merli ◽  
Giorgio Di Laura Frattura ◽  
Christian Candrian ◽  
Stefano Zaffagnini ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Randomized Controlled Trials ◽  
Placebo Effect ◽  
Meta Analysis ◽  
Grey Literature ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Level Of Evidence ◽  
Randomized Controlled ◽  
The Impact

Objectives To quantify the placebo effect of intraarticular injections for knee osteoarthritis in terms of pain, function, and objective outcomes. Factors influencing placebo effect were investigated. Design Meta-analysis of randomized controlled trials; Level of evidence, 2. PubMed, Web of Science, Cochrane Library, and grey literature databases were searched on January 8, 2020, using the string: (knee) AND (osteoarthritis OR OA) AND (injections OR intra-articular) AND (saline OR placebo). The following inclusion criteria were used: double-blind, randomized controlled trials on knee osteoarthritis, including a placebo arm on saline injections. The primary outcome was pain variation. Risk of bias was assessed using the RoB 2.0 tool, and quality of evidence was graded following the GRADE (Grading of Recommendations Assessment, Development and Evaluation) guidelines. Results Out of 2,363 records, 50 articles on 4,076 patients were included. The meta-analysis showed significant improvements up to the 6-month follow-up: Visual Analogue Scale (VAS)-pain −13.4 mean difference (MD) (95% confidence interval [CI]: −21.7/−5.1; P < 0.001), Western Ontario and McMaster Osteoarthritis Index (WOMAC)-pain −3.3 MD (95% CI: −3.9/−2.7; P < 0.001). Other significant improvements were WOMAC-stiffness −1.1 MD (95% CI: −1.6/−0.6; P < 0.001), WOMAC-function −10.1 MD (95% CI: −12.2/−8.0; P < 0.001), and Evaluator Global Assessment −21.4 MD (95% CI: −29.2/−13.6; P < 0.001). The responder rate was 52% (95% CI: 40% to 63%). Improvements were greater than the “minimal clinically important difference” for all outcomes (except 6-month VAS-pain). The level of evidence was moderate for almost all outcomes. Conclusions The placebo effect of knee injections is significant, with functional improvements lasting even longer than those reported for pain perception. The high, long-lasting, and heterogeneous effects on the scales commonly used in clinical trials further highlight that the impact of placebo should not be overlooked in the research on and management of knee osteoarthritis.

A Meta-Analysis to Estimate the Placebo Effect in Randomized Controlled Trials in Juvenile Idiopathic Arthritis

2016 ◽  
Vol 68 (6) ◽  
pp. 1540-1550 ◽  
Author(s):  
Erkan Demirkaya ◽  
Stefano Lanni ◽  
Francesca Bovis ◽  
Roberta Galasso ◽  
Angelo Ravelli ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Randomized Controlled Trials ◽  
Placebo Effect ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled

PD44-12 FEMALE SEXUAL DYSFUNCTION TREATMENT: A META-ANALYSIS OF THE PLACEBO EFFECT ACROSS RANDOMIZED CONTROLLED TRIALS

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
James M. Weinberger ◽  
Justin Houman ◽  
Ashley Caron ◽  
Avi S. Baskin ◽  
A. Lenore Ackerman ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Randomized Controlled Trials ◽  
Placebo Effect ◽  
Female Sexual Dysfunction ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals The placebo effect and its determinants in fibromyalgia: meta-analysis of randomised controlled trials

2017 ◽  
Vol 36 (7) ◽  
pp. 1623-1630 ◽  
Author(s):  
Xi Chen ◽  
Kun Zou ◽  
Natasya Abdullah ◽  
Nicola Whiteside ◽  
Aliya Sarmanova ◽  
...  
Keyword(s):  
Placebo Effect ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomised Controlled
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