scholarly journals Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis

2017 ◽  
Vol 2 ◽  
pp. 126-130 ◽  
Author(s):  
Sevilay Kılıç ◽  
Hatice Reşorlu ◽  
Selda Işık ◽  
Sibel Oymak ◽  
Ayla Akbal ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Disease Severity ◽  
Mean Platelet Volume ◽  
Platelet Volume

Mean platelet volume in psoriasis and psoriatic arthritis

2009 ◽  
Vol 29 (3) ◽  
pp. 325-328 ◽  
Author(s):  
Filiz Canpolat ◽  
Hatice Akpınar ◽  
Fatma Eskioğlu
Keyword(s):  
Psoriatic Arthritis ◽  
Mean Platelet Volume ◽  
Platelet Volume

Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis

2012 ◽  
Vol 36 (2) ◽  
pp. 162-168 ◽  
Author(s):  
Yavuz Beyazit ◽  
Abdurrahim Sayilir ◽  
Serkan Torun ◽  
Burak Suvak ◽  
Yusuf Yesil ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Disease Severity ◽  
Mean Platelet Volume ◽  
Platelet Volume

scholarly journals Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

2020 ◽  
Vol 9 (1) ◽  
pp. 186 ◽  
Author(s):  
Rosalynn RZ Conic ◽  
Giovanni Damiani ◽  
Kory P. Schrom ◽  
Amy E. Ramser ◽  
Chunlei Zheng ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Psoriatic Arthritis ◽  
Chronic Heart Failure ◽  
Mean Platelet Volume ◽  
Cell Distribution ◽  
Platelet Volume ◽  
Distribution Width ◽  
Increased Risk

In a subset of psoriasis (PsO) and psoriatic arthritis (PsA) patients, the skin and/or joint lesions appear to generate biologically significant systemic inflammation. Red cell distribution width (RDW) and mean platelet volume (MPV) are readily available clinical tests that reflect responses of the bone marrow and/or plasma thrombogenicity (e.g., inflammation), and can be markers for major adverse cardiac events (MACE). We aimed to evaluate if RDW and MPV may be employed as inexpensive, routinely obtained biomarkers in predicting myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) in psoriatic and psoriatic arthritis patients. The study was divided into two parts: (a) case control study employing big data (Explorys) to assess MPV and RDW in psoriasis, psoriatic arthritis and control cohorts; (b) a clinical observational study to validate the predictive value of RDW and to evaluate RDW response to anti-psoriatic therapies. We used Explorys, an aggregate electronic database, to identify psoriatic patients with available MPV and RDW data and compared them to gender and age matched controls. The incidence of myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) was highest among patients with both elevated RDW and MPV, followed by patients with high RDW and normal MPV. RDW elevation among PsA patients was associated with an increased risk of MI, AF, and CHF. In a local clinical cohort, high RDWs were concentrated in a subset of patients who also had elevated circulating resistin levels. Among a small subset of participants who were treated with various systemic and biologic therapies, and observed over a year, and in whom RDW was elevated at baseline, a sustained response to therapy was associated with a decrease in RDW. RDW and MPV, tests commonly contained within routine complete blood count (CBC), may be a cost-effective manner to identify PsO and PsA patients at increased risk of MACE.

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