scholarly journals Roles of Intracellular Signaling Pathways Regulating the KATP Channel and Mitochondria in Myocardial Protection from Ischemia/Reperfusion Injury

2018 ◽  
Vol 38 (2) ◽  
pp. 148-154
Author(s):  
Tetsuji Miura ◽  
Masaya Tanno ◽  
Yugo Fujita
Keyword(s):  
Reperfusion Injury ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Myocardial Protection ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intracellular Signaling Pathways

Signaling pathways of a structural analogue of apelin-12 involved in myocardial protection against ischemia/reperfusion injury

Peptides ◽  
2015 ◽  
Vol 73 ◽  
pp. 67-76 ◽  
Author(s):  
Oleg I. Pisarenko ◽  
Valentin S. Shulzhenko ◽  
Irina M. Studneva ◽  
Larisa I. Serebryakova ◽  
Yulia A. Pelogeykina ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Signaling Pathways ◽  
Myocardial Protection ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Structural Analogue

scholarly journals Myocardial protection from ischemia/reperfusion injury by exogenous galanin fragment

Oncotarget ◽  
2017 ◽  
Vol 8 (13) ◽  
pp. 21241-21252 ◽  
Author(s):  
Andrei Timotin ◽  
Oleg Pisarenko ◽  
Maria Sidorova ◽  
Irina Studneva ◽  
Valentin Shulzhenko ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Protection ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion

The Mechanism of Gastrodin Participating in Improving the Cerebral Ischemia-Reperfusion Injury Through Notch 1 and NF-κB Signaling Pathways

2021 ◽  
Vol 11 (2) ◽  
pp. 271-275
Author(s):  
Qing Hong ◽  
Junqiang Ye ◽  
Xijia Wang ◽  
Chao Zhang
Keyword(s):  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Signaling Pathways ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Brain Area ◽  
Notch 1 ◽  
Neuroprotective Effects ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion Injury

Background: The purpose of this study was to investigate whether Gastrodin can activate the Notch 1 signaling pathway in the ischemic brain area to produce neuroprotective effects against cerebral ischemia-reperfusion injury, and to elucidate the role of Notch 1 and NF-κB signaling pathways in the Gastrodin-induced cerebral ischemic tolerance. Material and methods: The focal cerebral ischemia reperfusion model of middle cerebral artery embolism was established. TTC staining was applied to detect cerebral infarction. Tunel/NeuN immunofluorescence double labeling was employed to detect apoptosis. WB was used to detect the expressions of proteins related to the Notch 1 and NF-κB pathways. Results: Gastrodin can reduce neuron apoptosis in hippocampus after MCAO/R injury. After DAPT blocked Notch 1 signaling, the neuroprotective effects of Gastrodin improving neural function score, reducing cerebral infarction volume, and inhibiting neuronal apoptosis, were all reversed. Compared with the MCAO/R group, DAPT blocking Notch 1 signaling can also improve the neurological score of rats after MCAO/R injury, reduce cerebral infarct volume, and reduce neuronal apoptosis. Gastrodin can activate Notch 1 and NF-κB signaling pathways in cerebral ischemic areas and increase the expression of related proteins. After DAPT inhibited the Notch 1 signaling in the ipsilateral brain region, the phosphorylation level was significantly decreased, indicating that the activity of the NF-κB pathway was regulated by the Notch 1 signaling. Conclusion: Gastrodin-mediated protection against cerebral ischemia-reperfusion injury is related to the activation of Notch 1 signaling and the up-regulation of NF-κB signaling pathway activity in neurons of ischemic brain area.

The effect of propofol on myocardial protection after regional ischemia-reperfusion injury in anin vivorat heart model

2008 ◽  
Vol 55 (3) ◽  
pp. 338 ◽  
Author(s):  
Il Woo Shin ◽  
Byeong Won Lim ◽  
Young Seok Chung ◽  
Hyo Min Lee ◽  
Ju Tae Sohn ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Protection ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heart Model ◽  
Regional Ischemia

scholarly journals CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Provides Myocardial Protection During Cardiac Ischemia/Reperfusion Injury

Circulation ◽  
2007 ◽  
Vol 116 (16) ◽  
pp. 1784-1794 ◽  
Author(s):  
David Köhler ◽  
Tobias Eckle ◽  
Marion Faigle ◽  
Almut Grenz ◽  
Michel Mittelbronn ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Protection ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cardiac Ischemia

Intraluminal-restricted 17β-estradiol exerts the same myocardial protection against ischemia/reperfusion injury in vivo as free 17β-estradiol

Steroids ◽  
2008 ◽  
Vol 73 (5) ◽  
pp. 528-538 ◽  
Author(s):  
Arturo Rodriguez-Hernandez ◽  
Ivan Rubio-Gayosso ◽  
Israel Ramirez ◽  
Israel Ita-Islas ◽  
Eduardo Meaney ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Protection ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
17Β Estradiol
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