Infections during pregnancy and after birth and risk of autism spectrum disorders: a register-based study utilizing a Danish historic birth cohort

10.5080/u6847 ◽  
2012 ◽  
Author(s):  
Morsi W. Abdallah ◽  
David M. Hougaard ◽  
Bent N�rgaard-Pedersen ◽  
Jakob Grove ◽  
Eva C. Bonefeld-J�rgensen ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Birth Cohort ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Epidemiological and Serological Investigation into the Role of Gestational Maternal Influenza Virus Infection and Autism Spectrum Disorders

mSphere ◽  
2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Milada Mahic ◽  
Xiaoyu Che ◽  
Ezra Susser ◽  
Bruce Levin ◽  
Ted Reichborn-Kjennerud ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Autism Spectrum Disorders ◽  
Virus Infection ◽  
Birth Cohort ◽  
Influenza Virus Infection ◽  
Epidemiological Studies ◽  
Autism Spectrum ◽  
Positive Serology ◽  
Influenza Like Illness ◽  
Spectrum Disorders

ABSTRACT The causes of most cases of autism spectrum disorders (ASD) are unknown. Some epidemiological studies suggest that maternal gestational influenza virus infection may increase the risk of ASD in offspring. Here, we describe an analysis of a large birth cohort with results based on questionnaires that prospectively addressed subjective reports of influenza-like illness and serological assays for objective determination of influenza virus infection. Although serologic evidence of gestational influenza virus infection alone was not associated with risk, positive serology and symptoms of influenza-like illness cannot yet be definitely ruled out as a risk factor. The literature concerning gestational maternal influenza virus infection and risk of autism spectrum disorders (ASD) is inconclusive. To address this uncertainty, we obtained information from questionnaires and samples from the Autism Birth Cohort, a prospective birth cohort comprising mothers, fathers, and offspring recruited in Norway in 1999 to 2008. Through questionnaires, referrals, and linkages to the Norwegian National Patient Registry, we identified 338 mothers of children with ASD and 348 frequency-matched controls for whom plasma samples that had been collected midpregnancy and after delivery were available for influenza virus serology via luciferase immunoprecipitation and hemagglutinin inhibition assays for influenza virus strains circulating during the study period. Assay data were combined to define serological status and integrated with self-reports of influenza-like illness to estimate ASD risk. Neither influenza A nor influenza B virus infection was associated with increased ASD risk. Integration of reports of symptoms of influenza-like illness with serology revealed an increase in risk for seropositive women with symptoms, but this increase did not achieve statistical significance (a level of P < 0.05) in the comparison with seronegative women without symptoms (adjusted odds ratio, 1.93; 95% confidence interval, 0.95 to 3.89; P = 0.068). Although chance may explain our findings, the magnitude of the potential association may be of biological importance, and dismissing our findings could result in failure to detect a bona fide association (type II error). If the association is true, we posit that the risk is due to activation of the maternal immune system following infection rather than direct fetal infection. Data on levels of cytokines or other mediators of inflammation would allow us to test the validity of this hypothesis. IMPORTANCE The causes of most cases of autism spectrum disorders (ASD) are unknown. Some epidemiological studies suggest that maternal gestational influenza virus infection may increase the risk of ASD in offspring. Here, we describe an analysis of a large birth cohort with results based on questionnaires that prospectively addressed subjective reports of influenza-like illness and serological assays for objective determination of influenza virus infection. Although serologic evidence of gestational influenza virus infection alone was not associated with risk, positive serology and symptoms of influenza-like illness cannot yet be definitely ruled out as a risk factor.

Assisted reproductive technology has no association with autism spectrum disorders: The Taiwan Birth Cohort Study

Autism ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 377-384 ◽  
Author(s):  
For-Wey Lung ◽  
Tung-Liang Chiang ◽  
Shio-Jean Lin ◽  
Meng-Chih Lee ◽  
Bih-Ching Shu
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum Disorders ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Birth Cohort ◽  
Assisted Reproduction ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Assisted Reproduction Technology ◽  
Spectrum Disorders

The use of assisted reproduction technology has increased over the last two decades. Autism spectrum disorders and assisted reproduction technology share many risk factors. However, previous studies on the association between autism spectrum disorders and assisted reproduction technology have shown inconsistent results. The purpose of this study was to investigate the association between assisted reproduction technology and autism spectrum disorder diagnosis in a national birth cohort database. Furthermore, the results from the assisted reproduction technology and autism spectrum disorder propensity score matching exact matched datasets were compared. For this study, the 6- and 66-month Taiwan Birth Cohort Study datasets were used (N = 20,095). In all, 744 families were propensity score matching exact matched and selected as the assisted reproduction technology sample (ratio of assisted reproduction technology to controls: 1:2) and 415 families as the autism spectrum disorder sample (ratio of autism spectrum disorder to controls: 1:4). Using a national birth cohort dataset, controlling for the confounding factors of assisted reproduction technology conception and autism spectrum disorder diagnosis, both assisted reproduction technology and autism spectrum disorder propensity score matching matched datasets showed the same results of no association between assisted reproduction technology and autism spectrum disorder. Further study on the detailed information regarding the processes and methods of assisted reproduction technology may provide us with more information on the association between assisted reproduction technology and autism spectrum disorder.

Neonatal levels of cytokines and risk of autism spectrum disorders: An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank

2012 ◽  
Vol 252 (1-2) ◽  
pp. 75-82 ◽  
Author(s):  
Morsi W. Abdallah ◽  
Nanna Larsen ◽  
Erik L. Mortensen ◽  
Hjördis Ó. Atladóttir ◽  
Bent Nørgaard-Pedersen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Autism Spectrum Disorders ◽  
Newborn Screening ◽  
Birth Cohort ◽  
Autism Spectrum ◽  
Birth Cohort Study ◽  
Spectrum Disorders

Psychiatric comorbidities in autism spectrum disorders: findings from a Danish Historic Birth Cohort

2011 ◽  
Vol 20 (11-12) ◽  
pp. 599-601 ◽  
Author(s):  
Morsi W. Abdallah ◽  
Kirstin Greaves-Lord ◽  
Jakob Grove ◽  
Bent Nørgaard-Pedersen ◽  
David M. Hougaard ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Birth Cohort ◽  
Autism Spectrum ◽  
Psychiatric Comorbidities ◽  
Spectrum Disorders

Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study

Cytokine ◽  
2013 ◽  
Vol 61 (2) ◽  
pp. 370-376 ◽  
Author(s):  
Morsi W. Abdallah ◽  
Nanna Larsen ◽  
Jakob Grove ◽  
Eva C. Bonefeld-Jørgensen ◽  
Bent Nørgaard-Pedersen ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Birth Cohort ◽  
Autism Spectrum ◽  
Follow Up Study ◽  
Spectrum Disorders

O-01 - The role of immune dysfunction in the pathophysiology of autism spectrum disorders: findings from a danish historic birth cohort

2012 ◽  
Vol 27 ◽  
pp. 1 ◽  
Author(s):  
M.W. Abdallah ◽  
D.M. Hougaard ◽  
J. Grove ◽  
B. Nørgaard-Pedersen ◽  
N. Larsen ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Birth Cohort ◽  
Immune Dysfunction ◽  
Autism Spectrum ◽  
Spectrum Disorders
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