scholarly journals A Population-Based Study for the Standardization of the Turkish Version of the Modified Mini Mental State Examination (3MS) and Assessment of Certain Environmental Risk Factors for Dementia: Methodology and Sample Characteristics

2018 ◽  
Author(s):  
Yavuz Ayhan ◽  
Ozge Karadag Caman ◽  
Sevilay Karahan ◽  
Sibel Kiran ◽  
Esen Saka ◽  
...  
Keyword(s):  
Risk Factors ◽  
Environmental Risk ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Population Based ◽  
Environmental Risk Factors ◽  
Turkish Version ◽  
Population Based Study ◽  
Sample Characteristics ◽  
State Examination

Autoimmune hepatitis: the role of environmental risk factors: a population-based study

2013 ◽  
Vol 7 (3) ◽  
pp. 869-875 ◽  
Author(s):  
Jing H. Ngu ◽  
Richard B. Gearry ◽  
Chris M. Frampton ◽  
Catherine A. M. Stedman
Keyword(s):  
Risk Factors ◽  
Autoimmune Hepatitis ◽  
Environmental Risk ◽  
Population Based ◽  
Environmental Risk Factors ◽  
Population Based Study

Comparison of the Montreal Cognitive Assessment and the Mini-Mental State Examination in detecting multi-domain mild cognitive impairment in a Chinese sub-sample drawn from a population-based study

2013 ◽  
Vol 25 (11) ◽  
pp. 1831-1838 ◽  
Author(s):  
YanHong Dong ◽  
Wah Yean Lee ◽  
Saima Hilal ◽  
Monica Saini ◽  
Tien Yin Wong ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mental State ◽  
Cognitive Assessment ◽  
Discriminant Validity ◽  
Mini Mental State Examination ◽  
Population Based ◽  
Montreal Cognitive Assessment ◽  
Population Based Study ◽  
State Examination

ABSTRACTBackground:We examined the discriminant validity of the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) in detecting multiple-domain mild cognitive impairment (md-MCI) in a Chinese sub-sample drawn from elderly population-based study.Methods:This study included Chinese participants from the Epidemiology of Dementia in Singapore (EDIS) study aged ≥ 60 years who underwent cognitive screening with the Abbreviated Mental Test and Progressive Forgetfulness Questionnaire. Screen-positive participants subsequently underwent MoCA, MMSE, and a comprehensive formal neuropsychological battery. MCI was defined by Petersen's criteria and further classified into single-domain MCI (sd-MCI) and md-MCI. Area under the receiver operating characteristic curve (AUC) with 95% confidence intervals (CIs) was computed for the MoCA and the MMSE in detecting md-MCI.Results:A total of 300 participants were recruited: 128 (42.7%) were diagnosed with no cognitive impairment (NCI), 47 (15.7%) with sd-MCI, and 83 (28.0%) with md-MCI. Forty-one participants were excluded, 7 (2.3%) had dementia, and 34 (11.3%) had only objective cognitive impairment without subjective complaints. Although the MoCA had a significantly larger AUC than the MMSE (0.94 (95% CI = 0.91–0.97) vs. 0.91 (95% CI = 0.86–0.95), p= 0.04), at optimal cut-off points, the MoCA (19/20) was equivalent to the MMSE (25/26) in detecting md-MCI (sensitivity: 0.80 vs. 0.87, specificity: 0.92 vs. 0.80).Conclusion:Both screening tests had good discriminant validity and can be used in detecting md-MCI in a sub-sample of Chinese drawn from a population-based study.

The prevalence of dementia in a population-based study carried out in Granarolo, Ravenna

2002 ◽  
Vol 11 (4) ◽  
pp. 258-265
Author(s):  
Diana De Ronchi ◽  
Elisa Bucchi ◽  
Monica Pederzini ◽  
Sara Scaini ◽  
Carmine Petio ◽  
...  
Keyword(s):  
Mental State ◽  
Mini Mental State Examination ◽  
Population Based ◽  
Global Deterioration Scale ◽  
Population Based Study ◽  
Allo Studio ◽  
Sono Stati ◽  
State Examination ◽  
Prevalence Of Dementia

RIASSUNTOScopo – Valutare la prevalenza della demenza e dei diversi tipi di demenza tra i soggetti con più di 60 anni d'eta residenti a Granarolo (RA) alia data del 31.12.1991. Disegno – Studio di popolazione, articolato in due fasi. Nella prima fase l'intera popolazione anziana e stata studiata mediante test di screening, nella seconda i soggetti positivi ai test sono stati sottoposti ad indagini più specifiche. Principali misure utilizzate – Nella prima fase sono stati utilizzati il Mini Mental State Examination (MMSE) e la Global Deterioration Scale (GDS). Nella seconda fase erano previste una visita medica, una valutazione neurologica, la somministrazione di test neuropsicologici e la diagnosi di demenza in accordo con i criteri del DSM-III-R. Risultati – Dei 557 partecipanti allo studio, 56 risultarono dementi. Per 29 persone fu formulata la diagnosi di Malattia di Alzheimer (AD) e per 14 pazienti la diagnosi di demenza di tipo vascolare (VaD). Il tasso di prevalenza della demenza era 11.1%, 9.1% per gli uomini (95% CI=5.29−12.89) e 12.7% per le donne (95% CI=8.84−16.6). La prevalenza della demenza nel suo insieme, cosi come dell'ad, aumentava in modo esponenziale ogni cinque anni in entrambi i sessi fino ai 90 anni di eta. Le donne evidenziavano una più elevata prevalenza della demenza in generale e di AD rispetto agli uomini e tale dato era più evidente nelle eta più avanzate. Conclusioni – I nostri dati concordano con quelli emersi in altri studi europei ed evidenziano come la prevalenza della demenza aumenti con l'elevarsi dell'eta. Se pensiamo che in Italia i grandi anziani (coloro con più di 80 anni) sono la parte di popolazione che aumenta più rapidamente rispetto alle altre fasce di eta, possiamo attenderci che la demenza diventera sempre più un problema di salute pubblica di grandissima rilevanza, essendo la più frequente patologia della popolazione molto anziana e causa primaria di disabilità e mortalità.

scholarly journals Persistent organic pollutants-environmental risk factors for diabetes mellitus? – A population-based study

2021 ◽  
Vol 25 (3) ◽  
pp. 157
Author(s):  
Sudha Ramalingam ◽  
Ramanujam Narayanan ◽  
Sivaselvakumar Muthusamy ◽  
Merlin Veronika ◽  
Ramalingam Sankaran ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Environmental Risk ◽  
Population Based ◽  
Environmental Risk Factors ◽  
Population Based Study

The 37 item Version of the Mini-Mental State Examination: Normative Data in a Population-Based Cohort of Older Spanish Adults (NEDICES)

2016 ◽  
Vol 31 (3) ◽  
pp. 263-272 ◽  
Author(s):  
I. Contador ◽  
F. Bermejo-Pareja ◽  
B. Fernández-Calvo ◽  
E. Boycheva ◽  
E. Tapias ◽  
...  
Keyword(s):  
Mental State ◽  
Normative Data ◽  
Mini Mental State Examination ◽  
Population Based ◽  
State Examination

scholarly journals Genetic and Environmental Risk Factors for Intracerebral Hemorrhage

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 321-321
Author(s):  
Daniel Woo ◽  
Laura Sauerbeck ◽  
Brett M Kissela ◽  
Jane C Khoury ◽  
Rakesh Shukla ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intracerebral Hemorrhage ◽  
Environmental Risk ◽  
Multivariable Analysis ◽  
Population Based ◽  
Environmental Risk Factors ◽  
Degree Relative ◽  
Increased Risk ◽  
Apo E ◽  
Apo E Genotype

27 Introduction: We report a planned midpoint analysis of a prospective, population-based, case-control study of the genetic and environmental risk factors of spontaneous, non-traumatic, intracerebral hemorrhage (ICH). Methods: Cases were matched to two controls by age, race and gender. Data was obtained by direct interview and review of all available medical and neuroimaging data. Apolipoprotein E (Apo E)genotype was determined by polymerase chain reaction. Multivariable analyses were performed using logistic regression modeling. Results: Between 6/97 and 2/00, 189 cases of ICH (150 white/39 black; 68 lobar/121 non-lobar) and 368 controls were enrolled into the study. Independent risk factors for multivariable analysis are listed in the table. Only prior stroke was an independent risk factor for both lobar and non-lobar ICH. Conclusions: The importance of individual genetic and environmental risk factors for ICH vary substantially by location of ICH. A history of a first-degree relative with ICH was associated with an increased risk of lobar ICH, independent of Apo E genotype. This finding indicates that other genetic risk factors may be important in the development of ICH.

Major depression and phobias: the genetic and environmental sources of comorbidity

1993 ◽  
Vol 23 (2) ◽  
pp. 361-371 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Michael C. Neale ◽  
Ronald C. Kessler ◽  
Andrew C. Heath ◽  
Lindon J. Eaves
Keyword(s):  
Risk Factors ◽  
Major Depression ◽  
Social Phobia ◽  
Environmental Risk ◽  
Population Based ◽  
Environmental Risk Factors ◽  
The Other ◽  
Genetic Vulnerability ◽  
Animal Phobias ◽  
Shared Genetic

SynopsisIn a population based sample of 2163 personally interviewed female twins, substantial comorbidity was observed between DSM-III-R defined major depression (MD) and 4 subtypes of phobia: agoraphobia, social phobia, animal phobia and situational phobia. However, the level of comorbidity of MD with agoraphobia was much greater than that found with the other phobic subtypes. We conducted bivariate twin analyses to decompose the genetic and environmental sources of comorbidity between MD and the phobias. Our results suggest that a modest proportion of the genetic vulnerability to MD also influences the risk for all phobic subtypes, with the possible exception of situational phobias. Furthermore, the magnitude of comorbidity resulting from this shared genetic vulnerability is similar across the phobic subtypes. By contrast, the non-familial environmental experiences which predispose to depression substantially increase the vulnerability to agoraphobia, have a modest impact on the risk for social and situational phobias and no effect on the risk for animal phobias. The increased comorbidity between MD and agoraphobia results, nearly entirely, from individual-specific environmental risk factors for MD which also increase the risk for agoraphobia but not for other phobias.

scholarly journals Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder

Brain ◽  
2020 ◽  
Author(s):  
Dario Arnaldi ◽  
Andrea Chincarini ◽  
Michele T Hu ◽  
Karel Sonka ◽  
Bradley Boeve ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Mental State ◽  
Rem Sleep ◽  
Mini Mental State Examination ◽  
Rating Scale ◽  
Bayesian Classifier ◽  
Examination Score ◽  
Sleep Behaviour ◽  
State Examination

Abstract This is an international multicentre study aimed at evaluating the combined value of dopaminergic neuroimaging and clinical features in predicting future phenoconversion of idiopathic REM sleep behaviour (iRBD) subjects to overt synucleinopathy. Nine centres sent 123I-FP-CIT-SPECT data of 344 iRBD patients and 256 controls for centralized analysis. 123I-FP-CIT-SPECT images were semiquantified using DaTQUANTTM, obtaining putamen and caudate specific to non-displaceable binding ratios (SBRs). The following clinical variables were also analysed: (i) Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale, motor section score; (ii) Mini-Mental State Examination score; (iii) constipation; and (iv) hyposmia. Kaplan-Meier survival analysis was performed to estimate conversion risk. Hazard ratios for each variable were calculated with Cox regression. A generalized logistic regression model was applied to identify the best combination of risk factors. Bayesian classifier was used to identify the baseline features predicting phenoconversion to parkinsonism or dementia. After quality check of the data, 263 iRBD patients (67.6 ± 7.3 years, 229 males) and 243 control subjects (67.2 ± 10.1 years, 110 males) were analysed. Fifty-two (20%) patients developed a synucleinopathy after average follow-up of 2 years. The best combination of risk factors was putamen dopaminergic dysfunction of the most affected hemisphere on imaging, defined as the lower value between either putamina (P < 0.000001), constipation, (P < 0.000001) and age over 70 years (P = 0.0002). Combined features obtained from the generalized logistic regression achieved a hazard ratio of 5.71 (95% confidence interval 2.85–11.43). Bayesian classifier suggested that patients with higher Mini-Mental State Examination score and lower caudate SBR asymmetry were more likely to develop parkinsonism, while patients with the opposite pattern were more likely to develop dementia. This study shows that iRBD patients older than 70 with constipation and reduced nigro-putaminal dopaminergic function are at high risk of short-term phenoconversion to an overt synucleinopathy, providing an effective stratification approach for future neuroprotective trials. Moreover, we provide cut-off values for the significant predictors of phenoconversion to be used in single subjects.

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