scholarly journals An In-Depth Analysis of the Novel SARS-CoV-2

2021 ◽  
Vol 13 (2) ◽  
Author(s):  
Joseph Younan
Keyword(s):  
The Novel ◽  
Depth Analysis

scholarly journals Speaking Truth to Power: Exploring Guru Nanak’s Bābar-vāṇī in Light of the Baburnama

Religions ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 328 ◽  
Author(s):  
Pashaura Singh
Keyword(s):  
The Novel ◽  
Critical Events ◽  
Depth Analysis ◽  
The Impact ◽  
The Relationship ◽  
Speaking Truth To Power

This essay offers in-depth analysis of Guru Nanak’s works, collectively known as the Bābar-vāņī (“arrow-like utterances concerning Babur”), in the context of the memoirs of the first Mughal emperor Babur (1483–1530). It extends the number of works in the collection from a ‘fixed’ assemblage of ‘four’ to ‘nine,’ making it an open collection that dynamically responds to the specific questions raised by historians about Guru Nanak’s encounter with Babur. The resulting framework provides us with a fresh analytical gaze into the critical events related to Babur’s invasions of India and helps the novel readings of Guru Nanak’s verses shine through. It also examines how Guru Nanak’s voice of resistance was interpreted in the narratives produced by later generations. Departing from traditional views, the essay ends with a new understanding of the impact of the Bābar-vāṇī on the evolving Sikh conceptions of the relationship between spiritual and political powers.

scholarly journals Seeing the Novel, Reading the Film: Unveiling Masculinity, Englishness and Power Struggle in Arthur Conan Doyle’s The Hound of the Baskervilles

2014 ◽  
Vol 23 (1) ◽  
pp. 60-76
Author(s):  
Irina I. Simonova Strout
Keyword(s):  
British History ◽  
Moral Code ◽  
The Novel ◽  
Power Struggle ◽  
Visual Interpretation ◽  
Economic Changes ◽  
The Public ◽  
Depth Analysis ◽  
Russian Film ◽  
Novel Reading

Abstract Masculinity as a notion encompasses a number of identities, including psychic and social ones. During the late Victorian and early Edwardian period, masculinity as a construct underwent many changes, which affected notions of work, property ownership, sexuality, as well as power struggle with men-rivals and women. The concept of ‘manliness’ became a new moral code as well as a social imperative. Embracing this ideal was a challenging and testing experience for many men as they negotiated power, privilege and status in both the private and the public spheres of life. The Edwardian age, a transitional time in British history, became preoccupied with the consequences of the Boer Wars, gender formation, imperial policy, economic changes and many other factors. This article explores the paradigms of English masculinity and the construction of male identity as a cultural signifier in Arthur Conan Doyle’s novel The Hound of the Baskervilles and its Russian film adaptation by Igor Maslennikov. Doyle contextualizes multiple facets of masculinity from the normative to the transgressive, from the private to the public, as well as from the effeminate to the manly as his characters are affected by the anxieties and tensions of their society. After an in-depth analysis of manhood in the novel, the focus of the article shifts to Maslennikov’s adaptation and its cinematic use of the literary text, as the film interrogates masculine codes of behavior, relationships with women and the male power struggle represented in the novel. The film becomes a visual interpretation and a powerful enhancement of the narrative’s tensions and concerns.

scholarly journals Role of RBC membrane protein palmitoylation in regulation of molecular topology and susceptibility to Plasmodium falciparum invasion

2020 ◽  
Author(s):  
Soumya Pati ◽  
Preeti Yadav ◽  
Geeta Kumari ◽  
Rex D.A.B ◽  
Sangam Goswami ◽  
...  
Keyword(s):  
The Novel ◽  
Molecular Topology ◽  
Parasite Invasion ◽  
Rbc Membrane ◽  
Protein Pool ◽  
Depth Analysis ◽  
Protein Palmitoylation ◽  
Specific Receptors ◽  
First Time

AbstractSqueezability of biconcave RBC raises a fundamental query, about, how it can restructure its bendable cytoskeleton for efficient micro-circulation. We report for the first time, the existence of dynamic palmitoylome in RBC composed of 118 palmitoylated proteins that reduced to 42 upon treatment with 2BP, a generic inhibitor of palmitoylation. In-depth analysis revealed that Semaphorin7A, CR1 and ABCB6, the known RBC receptors for P. falciparum were reduced to negligible in 2BP-treated RBCs, suggesting palmitoylation-dependent recruitment of parasite-specific receptors. Interestingly, Kell, a single disulphide-linked co-partner in Kell-Kx complex was undetected in 2BP-treated RBCs, while Kx remained intact. RBCs-blocked with anti-Kell antibody demonstrated signficant reduction in parasite invasion, thus suggesting it as a receptor proto-type for P. falciparum invasion. Finally, reduced expression of Kell in palmitoylated protein pool of sickle-cell RBC ghost, with its diminished surface representation in these RBCs, proposed Kell, as one of the novel receptor-prototype for P. falciparum invasion.

scholarly journals Oblicza Wolanda. Literackie studium postaci

2020 ◽  
Vol 20 ◽  
pp. 386-401
Author(s):  
Igor Przebinda
Keyword(s):  
The Novel ◽  
Depth Analysis ◽  
The Master And Margarita ◽  
Master And Margarita

The purpose of this paper is to present the description of Woland as one of the main characters of the novel by Bulgakov 'The Master and Margarita', after gaining experience connected with the work on a new translation of this book. The study was conducted on the basis of an in‑depth analysis of the text. The author distinguishes the roles in which Woland appears in relationships with other characters, as well as mental and physical transformations which he undergoes. A lot of remarks concern the changes in stylistic register of his utterances. Moreover, the analysis includes numerous names, which the narrator himself uses in reference to the character. Finally, analogies with other authors are presented (Goethe, Gogol, Poe). The paper is an attempt at reconstructing the viewpoint represented by Woland, including the multitude of elements referring to particular philosophical, political and ethical doctrines. It all leads to the conclusion that Bulgakov’s devil is a multidimensional and ambiguos character, which doesn’t conform to any traditions and explicit interpretations.

scholarly journals NARCISSISM IN PAULA HAWKINS' NOVEL THE GIRL ON THE TRAIN

2021 ◽  
Vol 5 (1) ◽  
pp. 170-178
Author(s):  
Riska Rahayu Roisiah ◽  
Pramudana Ihsan ◽  
Wijayadi Wijayadi
Keyword(s):  
Mental Disorder ◽  
Interpersonal Relationships ◽  
Common Mental Disorder ◽  
Psychoanalytic Theory ◽  
The Novel ◽  
Main Character ◽  
Social Conscience ◽  
Self Confidence ◽  
Common Diseases ◽  
Depth Analysis

Narcissism is one of the most common diseases in psychology, but its concern is the least. Therefore, this research was focused on narcissism disorder of one of the main characters named Megan Hipwell in the novel The Girl on the Train by Paula Hawkin. The analysis was done by applying psychoanalytic theory, in narcissism, which is the most common mental disorder among the members of a society. The method of research was qualitative, which required an in-depth analysis of the literary works used by the writers of this research according to the selected theories. The analysis was aimed to find illustrations and evidence of the main character in the novel The Girl on the Train to illustrate narcissism disorder. In this research, it was found that the main character suffered from narcissistic disorder, such as big ego, over-self confidence, exploitation of Interpersonal relationships, arrogance, and deficient social conscience. The triggers were rationalization and projection.

scholarly journals Natural Product Scores and Fingerprints Extracted from Artificial Neural Networks.

2021 ◽  
Author(s):  
Janosch Menke ◽  
Joana Massa ◽  
Oliver Koch
Keyword(s):  
Neural Networks ◽  
Natural Products ◽  
Artificial Neural Networks ◽  
Virtual Screening ◽  
Natural Product ◽  
Recent Work ◽  
The Novel ◽  
Multi Layer Perceptron ◽  
Output Layer ◽  
Depth Analysis

<div>Due to its desirable properties, natural products are an important ligand class for medicinal chemists. However, due to their structural distinctiveness, traditional cheminformatic approaches, like ligand-based virtual screening, often perform worse for natural products. Based on our recent work, we evaluated the ability of neural networks to generate fingerprints more appropriate for the use with natural products. A manually curated dataset of natural products and synthetic decoys was used to train a multi-layer perceptron network and an autoencoder-like network. An in-depth analysis showed that the extracted natural product specific neural fingerprints outperforms traditional as well as natural product specific fingerprints on three datasets. Further, we explore how the activation from the output layer of a network can work as a novel natural product likeness score. Overall two natural product specific datasets were generated, which are publicly available together with the code to create the fingerprints and the novel natural product likeness score.<br></div>

Recent Advances in System Based Study for Anti-Malarial Drug Development Process

2019 ◽  
Vol 25 (31) ◽  
pp. 3367-3377 ◽  
Author(s):  
Brijesh S. Yadav ◽  
Navaneet Chaturvedi ◽  
Ninoslav Marina
Keyword(s):  
Drug Discovery ◽  
Large Scale ◽  
New Drugs ◽  
The Novel ◽  
Sequencing Data ◽  
Drug Molecules ◽  
Genes Expression ◽  
Depth Analysis ◽  
New Generation Sequencing ◽  
New Generation

Background: Presently, malaria is one of the most prevalent and deadly infectious disease across Africa, Asia, and America that has now started to spread in Europe. Despite large research being carried out in the field, still, there is a lack of efficient anti-malarial therapeutics. In this paper, we highlight the increasing efforts that are urgently needed towards the development and discovery of potential antimalarial drugs, which must be safe and affordable. The new drugs thus mentioned are also able to counter the spread of malaria parasites that have been resistant to the existing agents. Objective: The main objective of the review is to highlight the recent development in the use of system biologybased approaches towards the design and discovery of novel anti-malarial inhibitors. Method: A huge literature survey was performed to gain advance knowledge about the global persistence of malaria, its available treatment and shortcomings of the available inhibitors. Literature search and depth analysis were also done to gain insight into the use of system biology in drug discovery and how this approach could be utilized towards the development of the novel anti-malarial drug. Results: The system-based analysis has made easy to understand large scale sequencing data, find candidate genes expression during malaria disease progression further design of drug molecules those are complementary of the target proteins in term of shape and configuration. Conclusion: The review article focused on the recent computational advances in new generation sequencing, molecular modeling, and docking related to malaria disease and utilization of the modern system and network biology approach to antimalarial potential drug discovery and development.

Rethinking revisited: insights from an early rethinker

2016 ◽  
Vol 9 (4) ◽  
pp. 931-954 ◽  
Author(s):  
Lavagnon A. Ika ◽  
Jonas Söderlund
Keyword(s):  
The Novel ◽  
Brookings Institution ◽  
Policy And Practice ◽  
Content Type ◽  
Albert Hirschman ◽  
Depth Analysis ◽  
Cass Sunstein ◽  
Analytical Power ◽  
Lasting Influence

Purpose The purpose of this paper is to review and analyze Albert Hirschman’s landmark book Development Projects Observed, share its insights for managing big projects, discuss its theoretical implications and how it may contribute to the current understanding of project behavior, project management (PM), and in what way it may encourage the rethinking of PM. Design/methodology/approach The paper is based on an in-depth analysis of Hirschman’s book. The paper draws on the writings of Jeremy Adelman who authored Hirschman’s biography, Cass Sunstein and Michele Alacevich who, respectively, wrote the foreword and afterword of the Brookings Institution classic published in 2014. It also profits from the work of Robert Picciotto who first met Hirschman in 1964, and Bent Flyvbjerg who recently offered a test of validity for Hirschman’s “Hiding Hand” principle. Findings Albert Hirschman was an original thinker and, the authors argue in many ways, a father of PM scholarship. His ideas had profound implications for social sciences and lasting influence in academy, policy, and practice. Although, to a great extent based on studies of projects, his ideas have had surprisingly little impact on modern writings of PM. This paper contributes to amending this weakness in current literature on PM. The authors identify in Hirschman’s book a set of core ideas that possess analytical power for explaining problems in contemporary PM. They include the principle of the Hiding Hand, the power of context, the role of complexity and uncertainty, the unexpected project effects, project traits, and latitudes/disciplines. For all his work and way of research, the authors conclude that Hirschman is not only an early behavioral theorist in PM but equally an early rethinker of PM. Originality/value This is the first paper that offers a discussion of Hirschman’s ideas on contemporary projects, how to understand them, their behavior, including the principle of the Hiding Hand and other important nuggets of wisdom in his research such as the significance of project traits, latitudes, and disciplines. The authors discuss in what respects these ideas may enlighten PM practice and theory. This paper also conveys the novel idea that Hirschman is an early rethinker of PM.

scholarly journals A Contrapuntal Reading of Joseph Conrad’s Lord Jim in the Light of Edward Said’s Culture and Imperialism

2021 ◽  
Vol 9 (2) ◽  
pp. 68
Author(s):  
Md. Nawsher Oan ◽  
A.S.M. Mahbubur Rahman ◽  
Md. Faisal Haque ◽  
Md. Lutful Arafat ◽  
Sohrab Hossain
Keyword(s):  
Temporal Relationship ◽  
Research Paper ◽  
Qualitative Approach ◽  
The Novel ◽  
Depth Analysis ◽  
Relationship Of ◽  
Reading Study ◽  
The Relationship ◽  
The Way

This article targets to converge in analyzing the novel Lord Jim and Said’s Culture and Imperialism to illustrate the critical development of the term ‘contrapuntal reading’ that demonstrates spatial rather than temporal relationship between them. This study deeply endeavors to present the relation between the colonized and colonizer as it is marked in Said’s Culture and Imperialism that demonstrates Conrad’s Lord Jim while it exposes the relationship of Jim and all other characters and the experiences of Jim that he gathers in his journey in the novel. In addition, this study scrutinizes the different aspects related with the term ‘contrapuntal reading’-colonialism, modernism and imperialism. However, qualitative approach has been applied to analyze the novel Lord Jim. As a consequence, this effort will pave the way to interpret the novel Lord Jim with an in-depth analysis that will lead the researchers to investigate other texts under the light of the term ‘contrapuntal reading’. More specifically this research paper investigates the inner incidents that took place in the novel Lord Jim in the light of Said’s Culture and Imperialism to establish various relationships as a contrapuntal reading study.

scholarly journals Characterization and Design for Last Mile Logistics: A Review of the State of the Art and Future Directions

2021 ◽  
Vol 12 (1) ◽  
pp. 118
Author(s):  
Hyeong Suk Na ◽  
Sang Jin Kweon ◽  
Kijung Park
Keyword(s):  
Service Industry ◽  
Decision Makers ◽  
The Novel ◽  
Future Directions ◽  
Environmentally Sustainable ◽  
Market Risks ◽  
Last Mile ◽  
Delivery Technique ◽  
Depth Analysis ◽  
Delivery Services

One of the most challenging problems in last mile logistics (LML) has been the strategic delivery due to various market risks and opportunities. This paper provides a systematic review of LML-related studies to find current issues and future opportunities for the LML service industry. To that end, 169 works were selected as target studies for in-depth analysis of recent LML advances. First, text mining analysis was performed to effectively understand the underlying LML themes in the target studies. Then, the novel definition and typology of LML delivery services were suggested. Finally, this paper proposed the next generation of LML research through advanced delivery technique-based LML services, environmentally sustainable LML systems, improvement of LML operations in real industries, effective management of uncertainties in LML, and LML delivery services for decentralized manufacturing services. We believe that this systematic literature review can serve as a useful tool for LML decision makers and stakeholders.

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