Oral proliferative verrucous leukoplakia: Underdiagnosed oral precursor lesion that requires retrospective clinicopathological correlation

2010 ◽  
Vol 16 (5) ◽  
Author(s):  
Ozgur Mete ◽  
Yaren Keskin ◽  
Gunter Hafiz ◽  
Kivanc Bektas Kayhan ◽  
Meral Unur
Keyword(s):  
Clinicopathological Correlation ◽  
Precursor Lesion ◽  
Proliferative Verrucous Leukoplakia

Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta‐analysis

Oral Diseases ◽  
2021 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Fernanda Weber Mello ◽  
Jose V. Bagan ◽  
Saman Warnakulasuriya
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Proliferative Verrucous Leukoplakia

Granuloma annulare subtypes: sonographic features and clinicopathological correlation

2021 ◽  
Author(s):  
Nuria Rodríguez-Garijo ◽  
Alejandra Tomás-Velázquez ◽  
Angela Estenaga ◽  
Javier Antoñanzas ◽  
Maria Agustina Segurado-Rodríguez ◽  
...  
Keyword(s):  
Granuloma Annulare ◽  
Clinicopathological Correlation

Concurrent Endometrial Intraepithelial Carcinoma (EIC) and Serous Ovarian Cancer: Can EIC Be Seen as the Precursor Lesion?

2012 ◽  
Vol 22 (3) ◽  
pp. 457-464 ◽  
Author(s):  
Thijs Roelofsen ◽  
Léon C.L.T. van Kempen ◽  
Jeroen A.W.M. van der Laak ◽  
Maaike A. van Ham ◽  
Johan Bulten ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Expression Patterns ◽  
Neoplastic Progression ◽  
Precursor Lesion ◽  
Ki 67 ◽  
Cancer Management ◽  
Ploidy Analysis ◽  
Intraepithelial Carcinoma

ObjectiveThe pathogenesis of serous ovarian carcinoma (SOC) is still unknown. Recently, endometrial intraepithelial carcinoma (EIC) was proposed to be the precursor lesion of SOC. This study examines the model of EIC as precursor for SOC.MethodsCases of SOC with a noninvasive or superficially invasive serous lesion, a hyperplastic lesion with/without atypia, or EIC in the endometrium were selected for inclusion in this study. Tissue sections from both ovaries, the fallopian tubes, and the uterus were extensively reviewed by an expert gynecopathologist. For both EIC and SOC, immunostaining for p53, Ki-67, estrogen receptor, and progesterone receptor; TP53 mutation analysis; and in situ ploidy analysis were performed.ResultsNine cases of SOC with concurrent EIC in the endometrium were identified. Immunostaining for p53, Ki-67, estrogen receptor, and progesterone receptor revealed almost identical expression patterns and similar intensities in each pair of EIC and coincident SOC. Identical TP53 mutations were found in SOC and coinciding EIC in 33% of the cases, suggesting a clonal origin. DNA ploidy analysis, as a marker for neoplastic progression, demonstrated an increased number of aneuploid nuclei in SOC compared to their corresponding EIC (P = 0.039). In addition, the mean amount of DNA per nucleus in SOC was higher (ie, more aneuploid) compared to EIC (P = 0.039).ConclusionThis study provides a first indication of EIC as possible precursor lesion for SOC. This finding could have major clinical implications for future ovarian cancer management and underscores EIC as a possible target for early SOC detection and prevention.

Clinicopathological correlation of expression of MCM2 in patients with non-small cell lung cancer (NSCLC)

Lung Cancer ◽  
2000 ◽  
Vol 29 (1) ◽  
pp. 214
Author(s):  
N Ramnath ◽  
D Tan ◽  
F Hernandez ◽  
A Beck ◽  
G Loewen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Clinicopathological Correlation ◽  
Small Cell Lung
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