scholarly journals Scalp metastasis as initial presentation of neuroendocrine carcinoma

2021 ◽  
Vol 27 (9) ◽  
Author(s):  
Cynthia C Peng ◽  
Katherine T Burke ◽  
Michael A Cardis
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Initial Presentation ◽  
Scalp Metastasis

scholarly journals Primary small cell carcinoma of the vagina: a rare instance of prolonged survival

2019 ◽  
Vol 12 (3) ◽  
pp. e227100
Author(s):  
Sri Harsha Kombathula ◽  
Pragna Sagar Rapole ◽  
Shyama Sudha Prem ◽  
Bhawana Badhe
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Small Cell ◽  
Initial Presentation ◽  
Prolonged Survival ◽  
Stage Iii ◽  
Local Disease ◽  
Gynaecological Malignancies ◽  
Rare Instance

Small cell carcinoma (SmCC) of the vagina is a rare and aggressive tumour. It comprises only 1% –2% of all gynaecological malignancies 85% of the patients with SmCC vagina die within a year of diagnosis. Here we report the case of a 65-year-old woman with stage III primary neuroendocrine carcinoma of vagina who was treated with chemoradiotherapy. The patient survived 1 year and 10 months after the initial presentation. SmCC of the vagina is very rare and despite being aggressive, the local disease can be controlled with a chemoradiation regimen.

scholarly journals Scalp Metastasis as an Initial Presentation of Lung Cancer: A Case Report

2020 ◽  
Author(s):  
Seyyed Ehsan Horriyatkhahgavgani ◽  
Narjes Zarei ◽  
Soheil Peyman ◽  
Besharat Rahimi
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Lung Carcinoma ◽  
Clinical Signs ◽  
Diagnostic Evaluation ◽  
Initial Presentation ◽  
Unusual Presentation ◽  
Classical Form ◽  
Scalp Metastasis ◽  
Scalp Lesions

Introduction: Lung can be affected by various tumors, including lung carcinoma. These tumors exhibit certain clinical signs. In rare cases, they may appear unusual and affect the diagnostic and therapeutic course. Considering the importance of this issue, in the present study, we report a case of lung lymphoma with subsequent lump masses. We report a diagnostic evaluation in a male case with the first manifestation as an unusual presentation of scalp metastasis due to underlying lung cancer. Conclusion: Although lung cancer is typically presented in classical form, it is important to consider unusual manifestations of underlying lung cancer, along with the appearance of scalp lesions.

scholarly journals An Uncommon Case of Colonic Neuroendocrine Carcinoma with Scalp Metastasis

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S48-S48
Author(s):  
S S Karimi ◽  
M Braniecki
Keyword(s):  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Neuroendocrine Neoplasms ◽  
Nuclear Staining ◽  
Merkel Cell ◽  
Skin Punch Biopsy ◽  
Scalp Metastasis ◽  
Scalp Lesion

Abstract Introduction/Objective Neuroendocrine neoplasms of the colon account for <1% of all colorectal malignancies. While visceral metastasis of neuroendocrine neoplasms is commonly observed, cutaneous distant metastasis has infrequently been reported and correlates with an advance stage and progression of disease. To our knowledge, there have been only 10 cases of neuroendocrine neoplasms with metastasis to the scalp reported in the literature. Herein, we report an unusual case of colonic neuroendocrine carcinoma with scalp metastasis, that can be microscopically indistinguishable from the highly aggressive cutaneous neuroendocrine carcinoma, Merkel Cell Carcinoma. Methods/Case Report A 47-year-old female with a history of ileocecal neuroendocrine carcinoma and status post right hemicolectomy had developed liver metastasis and subsequently had an orthotopic liver transplant. PET scan later revealed multiple areas of increased activity involving the ribs, scalp and cervical lymph node that were concerning for malignancy. The scalp lesion consisted of a 7mm non-tender, mobile, violaceous, erythematous dermal nodule that was clinically concerning for cutaneous metastasis. A skin punch biopsy microscopically revealed a subcutaneous infiltrate of nests composed of neoplastic monotonous blue cells with the classic nuclear “salt and pepper” chromatin and scant eosinophilic cytoplasm. The lesional cells showed positive immunoreactivity for synaptophysin and chromogranin. With the given patient’s clinical history and presentation, the observed histological findings and immunophenotypic expression of the tumor cells supported a diagnosis of metastatic neuroendocrine carcinoma. Results (if a Case Study enter NA) N/A Conclusion Metastatic neuroendocrine carcinoma to the scalp is a rare entity and is infrequently encountered in dermatopathology. Given the location and the gross appearance of the scalp lesion, a wide differential diagnosis would include both benign and malignant tumors. In particular, Merkel Cell Carcinoma can grossly and histologically mimic metastatic colonic neuroendocrine carcinoma. Both entities would show synaptophysin and chromogranin uptake. However, metastatic tumors originating from the colon will demontrate CDX2 and SATB2 nuclear staining. We share this rare case of metastatic colonic neuroendocrine carcinoma as it is an important differential diagnosis for primary cutaneous Merkel Cell Carcinoma.

scholarly journals Flushing as atypical initial presentation of functional gallbladder neuroendocrine carcinoma: A case report

2020 ◽  
Vol 26 (6) ◽  
pp. 686-695 ◽  
Author(s):  
Ming Jin ◽  
Bo Zhou ◽  
Xiong-Ling Jiang ◽  
Qi-Yi Zhang ◽  
Xiang Zheng ◽  
...  
Keyword(s):  
Case Report ◽  
Neuroendocrine Carcinoma ◽  
Initial Presentation
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