scholarly journals A large hyperplastic nodule on the abdomen

2015 ◽  
Vol 21 (1) ◽  
Author(s):  
Yanfei Zhang ◽  
Zhengxiao Li ◽  
Shengxiang Xiao ◽  
Yiguo Feng
Keyword(s):  
Hyperplastic Nodule

scholarly journals Genotypic Differentiation of Intrahepatically Transplanted Hyperplastic Nodule Cells of Analbuminemic and Normal Rat Origin by Polymerase Chain Reaction

1990 ◽  
Vol 81 (8) ◽  
pp. 711-714 ◽  
Author(s):  
Yuji Nishikawa ◽  
Hirotsuka Sakai ◽  
Mitsuhiro Inagaki ◽  
Ikue Fukuda ◽  
Katsuhiro Ogawa ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Chain Reaction ◽  
Hyperplastic Nodule ◽  
Normal Rat ◽  
Polymerase Chain

Effect of Superparamagnetic Iron Oxide-Enhanced MRI of the Liver With Hepatocellular Carcinoma and Hyperplastic Nodule

2002 ◽  
Vol 26 (3) ◽  
pp. 451-455 ◽  
Author(s):  
Koji Takeshita ◽  
Ikuo Nagashima ◽  
Shigeru Frui ◽  
Koichi Takada ◽  
Teiyu Yamauchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Iron Oxide ◽  
Superparamagnetic Iron Oxide ◽  
Hyperplastic Nodule ◽  
Enhanced Mri

scholarly journals A case of hyperplastic nodule of the liver associated with aplastic anemia.

Kanzo ◽  
1999 ◽  
Vol 40 (3) ◽  
pp. 150-155 ◽  
Author(s):  
Yoshiaki MIURA ◽  
Ryujin ENDO ◽  
Atsushi NAKAMURA ◽  
Yasuhiro TAKIKAWA ◽  
Ichiro NAKADATE ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Hyperplastic Nodule

scholarly journals Thyroglobulin Gene Mutation with Cold Nodule on Thyroid Scintigraphy

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Toshio Kahara ◽  
Noboru Igarashi ◽  
Akira Hishinuma ◽  
Yuko Nakanishi ◽  
Akio Uchiyama ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Gene Mutation ◽  
Congenital Hypothyroidism ◽  
Elevated Serum ◽  
Gene Mutations ◽  
Thyroid Scintigraphy ◽  
Serum Thyroglobulin ◽  
Hyperplastic Nodule ◽  
Thyroglobulin Gene ◽  
Cold Nodule

Thyroglobulin gene mutation is a rare cause of congenital hypothyroidism, but thyroglobulin gene mutations are thought to be associated with thyroid cancer development. A 21-year-old Japanese man treated with levothyroxine for congenital hypothyroidism had an enlarged thyroid gland with undetectable serum thyroglobulin despite elevated serum TSH level. The patient was diagnosed with thyroglobulin gene mutation, with compound heterozygosity for Gly304Cys missense mutation and Arg432X nonsense mutation. Ultrasonography showed a hypovascular large tumor in the left lobe that appeared as a cold nodule on thyroid scintigraphy. He underwent total thyroidectomy, but pathological study did not reveal findings of thyroid carcinoma, but rather a hyperplastic nodule with hemorrhage. Strong cytoplasmic thyroglobulin immunostaining was observed, but sodium iodide symporter immunostaining was hardly detected in the hyperplastic nodule. The clinical characteristics of patients with thyroglobulin gene mutations are diverse, and some patients are diagnosed by chance on examination of goiter in adults. The presence of thyroid tumors that appear as cold nodules on thyroid scintigraphy should consider the potential for thyroid carcinoma, if the patient has relatively low serum thyroglobulin concentration in relation to the degree of TSH without thyroglobulin autoantibody.

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