scholarly journals Bud-Union Crease of Calamondin—a Non-Infectious Disorder

1968 ◽  
Vol 4 (4) ◽  
Author(s):  
Edward O. Olson ◽  
E. F. Frolich
Keyword(s):  
Infectious Disorder

scholarly journals Whipple's disease: rare disorder and late diagnosis

2012 ◽  
Vol 54 (5) ◽  
pp. 293-297 ◽  
Author(s):  
Viviane Plasse Renon ◽  
Marcelo Campos Appel-da-Silva ◽  
Rafael Bergesch D'Incao ◽  
Rodrigo Mayer Lul ◽  
Luciana Schmidt Kirschnick ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
Disease Diagnosis ◽  
Endoscopic Biopsy ◽  
Upper Gastrointestinal Endoscopy ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Polymerase Chain ◽  
One Year ◽  
Infectious Disorder

Whipple's disease is a rare systemic infectious disorder caused by the bacterium Tropheryma whipplei. We report the case of a 61-year-old male patient who presented to emergency room complaining of asthenia, arthralgia, anorexia, articular complaints intermittent diarrhea, and a 10-kg weight loss in one year. Laboratory tests showed the following results: Hb = 7.5 g/dL, albumin = 2.5 mg/dL, weight = 50.3 kg (BMI 17.4 kg/m²). Upper gastrointestinal endoscopy revealed areas of focal enanthema in the duodenum. An endoscopic biopsy was suggestive of Whipple's disease. Diagnosis was confirmed based on a positive serum polymerase chain reaction. Treatment was initiated with intravenous ceftriaxone followed by oral trimethoprim-sulfamethoxazole. After one year of treatment, the patient was asymptomatic, with Hb = 13.5 g/dL, serum albumin = 5.3 mg/dL, and weight = 70 kg (BMI 24.2 kg/m²). Whipple's disease should be considered a differential diagnosis in patients with prolonged constitutional and/or gastrointestinal symptoms. Appropriate antibiotic treatment improves the quality of life of patients.

scholarly journals Meningo-Ependymitis in Whipple's Disease

1980 ◽  
Vol 7 (2) ◽  
pp. 163-167 ◽  
Author(s):  
L.R. Lapointe ◽  
J. Lamarche ◽  
A. Salloum ◽  
R. Beaudry
Keyword(s):  
Complete Recovery ◽  
Whipple’S Disease ◽  
Gait Ataxia ◽  
Whipple's Disease ◽  
Inflammatory Infiltration ◽  
Asymptomatic Patients ◽  
Elevated Protein ◽  
Cerebral Involvement ◽  
Inflammatory Changes ◽  
Infectious Disorder

SUMMARY:Six years after apparent complete recovery from intestinal Whipple's disease, a 56 year old man developed insidious progressive somnolence and gait ataxia. Studies showed hydrocephalus with obstruction of the aqueduct and CSF leukocytosis and elevated protein. Arachnoid biopsy during craniotomy revealed chronic inflammatory infiltration with PAS-positive macrophages. The patient died 5 years later despite two courses of antibiotic therapy. This is the first report of histologically confirmed cerebral Whippie's disease during life.Whipple's disease is a systemic infectious disorder. Cerebral involvement even in neurologically asymptomatic patients should be sought with periodic CSF cytologic studies and a search for hydrocephalus. The possibility of cerebral Whipple's disease should be considered in the presence of unexplained hydrocephalus and/or chronic inflammatory changes in the spinal fluid, especially in those with past or active intestinal disease.

scholarly journals A review regarding virology, etiology, prevalence and associated risk factors of Hepatitis A.

2020 ◽  
pp. 129-137
Keyword(s):  
Hepatitis A ◽  
Cytotoxic T Cells ◽  
Acute Infection ◽  
Oral Route ◽  
Clinical Samples ◽  
Hepatocellular Injury ◽  
Short Term ◽  
B Virus ◽  
Associated Risk Factors ◽  
Infectious Disorder

Hepatitis A is an infectious disorder of the liver prompted by Hepatovirus A virus (HAV). It is a kind of viral hepatitis. It has naked nucleocapsid virus with a single stranded, positive polarity RNA. It is devoid of virion polymerase and has a single serotype. Transmission is via fecal–oral route. In contrast to Hepatitis B virus and Hepatitis C virus, blood borne transmission of HAV is infrequent because viremia is short-term and of low titer. Mostly instances, have few or no signs, specifically in younger ones. The virus replicates in the gastrointestinal tract and then spreads to the liver during a short-term viremic period. HAV is not cytopathic for the hepatocyte. Hepatocellular injury is triggered by immune attack by the cytotoxic T cells. The time among the infection and signs, in patients that progress them, is among two and six weeks. When the signs occur, they commonly last 8 weeks and might encompass nausea, vomiting, diarrhea, jaundice, pain in abdomen and fever. Around 10 to 15 percent of patients undergo a recurrence of signs at some stage in the six months after the preliminary infection. Acute liver failure may also seldom occur, with this being extra regular in elderly. No antiviral medication is available. The most suitable test to diagnose acute infection is IgM antibody. Isolation of the virus from clinical samples is not done. Vaccine consists of killed virus. Administration of immune globulin in the course of the incubation can alleviate the disease.

scholarly journals Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies

2017 ◽  
Vol 75 (6) ◽  
pp. 381-386 ◽  
Author(s):  
Vanessa van der Linden ◽  
Hélio van der Linden Junior ◽  
Mariana de Carvalho Leal ◽  
Epitacio Leite Rolim Filho ◽  
Ana van der Linden ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Zika Virus ◽  
Dizygotic Twin ◽  
Severe Damage ◽  
Congenital Zika Syndrome ◽  
The Central Nervous System ◽  
Natural Protection ◽  
Twin Pregnancies ◽  
Infectious Disorder

ABSTRACT Congenital Zika syndrome is an emergent cause of a congenital infectious disorder, resulting in severe damage to the central nervous system and microcephaly. Despite advances in understanding the pathophysiology of the disease, we still do not know all the mechanisms enrolled in the vertical transmission of the virus. As has already been reported in other types of congenital infectious disorders in dizygotic twin pregnancies, it is possible that the virus affects only one of the fetuses. In this article, we report on two cases of twin pregnancies exposed to the Zika virus, but with only one of the fetuses affected with microcephaly and brain damage. This indicates the urgent need for more studies regarding the pathophysiology of viral infection and the mechanisms involved in the natural protection against the virus.

scholarly journals Covid-19 related ataxia and myoclonus: Para- or post-infectious disorder?

2021 ◽  
Vol 429 ◽  
pp. 119782
Author(s):  
Matteo Grazzini ◽  
Elisa Giorli ◽  
Massimiliano Godani ◽  
Antonio Mannironi ◽  
Stefano Grisanti ◽  
...  
Keyword(s):  
Post Infectious ◽  
Infectious Disorder

scholarly journals Natural Product Emerging as Potential SARS Spike Glycoproteins-ACE2 Inhibitors to Combat COVID-19 Attributed by In-Silico Investigations

2020 ◽  
Vol 11 (3) ◽  
pp. 10628-10639
Keyword(s):  
Natural Products ◽  
In Silico ◽  
Therapeutic Drug ◽  
Spike Glycoprotein ◽  
Drug Candidates ◽  
Major Outbreak ◽  
Indigo Blue ◽  
In Vivo Assessment ◽  
Infectious Disorder

COVID-19 is a pandemic infectious disorder that emerged as a major outbreak for the community and health care system across the globe. Since the currently available drug therapeutics available for COVID-19 are prone to provide symptomatic and supportive relief, which has invited the entire scientist of all over the nations to investigate therapeutic drug candidates accompanied by anti-COVID-19 activity. The recognition of ACE2 mediated entry of SARS-CoV-2 encouraged us to investigate natural products as a potential inhibitor of the SARS spike glycoprotein-Human ACE2 complex. Using the strategy of molecular docking, we have assessed berberine, indigo blue, β-sitosterol, glycyrrhizin, indirubin, hesperetin, bicylogermacrene, β-caryophyllene, chrysophanic acid, rhein, curcumin, and eugenol for their inhibitory activity towards SARS spike glycoprotein-Human ACE2 complex. We have investigated including indigo blue, glycyrrhizin, β-sitosterol, indirubin, bicylogermacrene, curcumin, hesperetin, rhein, berberine with an affinity of -11.2, -10.9. -10.1, -9.8, -9.5, -9.3, -9.2, -9.1 and -9.0 kcal/mol respectively as in silico inhibitors of SARS spike glycoprotein-Human ACE2 complex which can vitalize the researchers for in-vivo assessment of these natural products.

scholarly journals STAGGERS IN SHEEP IN PATAGONIA

1917 ◽  
Vol 26 (6) ◽  
pp. 805-823 ◽  
Author(s):  
F. S. Jones ◽  
J. F. Arnold
Keyword(s):  
Experimental Work ◽  
Early Spring ◽  
Late Winter ◽  
Edible Portion ◽  
Motor Paralysis ◽  
Time Required ◽  
Infectious Disorder ◽  
Cattle And Sheep

After observations and experimental work both in the field and laboratory, the following conclusions seem justified. 1. Staggers is a non-infectious disorder affecting horses, cattle, and sheep. 2. The disease is characterized by weakness, muscular twitching, irregular movements of the head, stiffness of the limbs, and transient motor paralysis, accompanied with spastic spasms on excitement. There is also a derangement of vision and conjunctivitis. 3. The postmortem lesions are not characteristic. 4. We readily produced the disease by feeding susceptible sheep on a coarse tuft grass commonly known as coiron or pampa grass (Poa argentina). 5. The time required to produce definite symptoms by feeding the grass varied. Two animals developed typical staggers after two feedings; in another instance a period of 21 days of feeding was required. The average time for the production of unmistakable symptoms in our experiments was 10 days. 6. Many sheep recover from staggers spontaneously. A complete change of diet will usually effect a cure within 2 weeks. 7. Older .animals that have pastured for long periods on lands where the grass grows become tolerant and are rarely affected with staggers. 8. The grass is toxic to sheep at all seasons of the year. We fed late winter and early spring grass and grass in flower, and produced staggers in every instance. The young green grass is as toxic as any edible portion of the plant.

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