scholarly journals Disaccharidase Deficiency as a Cause of Unexplained Functional Gastrointestinal Disorder

2020 ◽  
Vol 26 (3) ◽  
pp. 295-296
Author(s):  
Yong Hwan Kwon
Keyword(s):  
Gastrointestinal Disorder ◽  
Functional Gastrointestinal Disorder

scholarly journals Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise—Searching for Gap Fillers in the Oxidative Stress Way of Thinking

Medicina ◽  
2020 ◽  
Vol 56 (1) ◽  
pp. 38 ◽  
Author(s):  
Ioana-Miruna Balmus ◽  
Ovidiu-Dumitru Ilie ◽  
Alin Ciobica ◽  
Roxana-Oana Cojocariu ◽  
Carol Stanciu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Irritable Bowel Syndrome ◽  
Gastrointestinal Disorder ◽  
Functional Gastrointestinal Disorder ◽  
Clinical Expertise ◽  
Related Disorder ◽  
Genetic Features ◽  
Exogenous Factors ◽  
Irritable Bowel ◽  
Patient Studies

Irritable bowel syndrome (IBS) remains to date an intriguing functional gastrointestinal disorder. Recent studies described a multitude of exogenous factors that work together in IBS, gradually impairing intestinal lining cellular metabolism, including oxidative status balance, with or without a genetic background. Although the current biomarkers support the differentiation between IBS subtypes and other functional gastrointestinal disorder, they are mostly non-specific, referring to clinical, biochemical, and inflammatory imbalances. Since IBS could be also the result of deficient signaling pathways involving both gastrointestinal secretion and neuro-vegetative stimulation, IBS makes no exception from the oxidative hypothesis in the pathological mechanisms. Regarding the oxidative stress implication in IBS, the previous research efforts showed controversial results, with some animal models and patient studies reporting clear oxidative imbalance both on systemic and local levels, but still with no concrete evidence to point to a direct correlation between oxidative stress and IBS. Additionally, it seems that a major role could be also attributed to gut microbiota and their ability to shape our bodies and behaviors. Moreover, the genetic features study in IBS patients showed that several genetic similarities point to a possible correlation of IBS with affective spectrum disorders. Thus, we focus here the discussion on the assumption that IBS could in fact be more likely a stress-related disorder rather than a gastrointestinal one.

A boy with duodenocolic fistula mimicking functional gastrointestinal disorder

2019 ◽  
Vol 12 (6) ◽  
pp. 566-570
Author(s):  
Yuko Okada ◽  
Koji Yokoyama ◽  
Tomonori Yano ◽  
Hideki Kumagai ◽  
Takaaki Morikawa ◽  
...  
Keyword(s):  
Gastrointestinal Disorder ◽  
Functional Gastrointestinal Disorder ◽  
Duodenocolic Fistula
Sign in / Sign up

Export Citation Format

Share Document