scholarly journals Is Long-term Ambient Air Pollutant Exposure a Risk Factor for Irritable Bowel Syndrome in Children? A 12-year Longitudinal Cohort Study

2019 ◽  
Vol 25 (2) ◽  
pp. 241-249 ◽  
Author(s):  
Teck-King Tan ◽  
Miguel Saps ◽  
Cheng-Li Lin ◽  
Chang-Ching Wei
Keyword(s):  
Irritable Bowel Syndrome ◽  
Risk Factor ◽  
Cohort Study ◽  
Ambient Air ◽  
Air Pollutant ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Irritable Bowel

scholarly journals Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kosuke Honda ◽  
Satoru Kuriyama ◽  
Kimiyoshi Ichida ◽  
Tomoko Nakano ◽  
Naoki Sugano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Renal Function ◽  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid Level ◽  
Human Growth ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

Abstract Background Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymorphism of IGF-1, rs35767, plays a role in metabolic syndrome indicators, including blood pressure, glucose metabolism, uric acid levels, and renal function. Methods In this retrospective longitudinal cohort study, blood samples from 1506 Japanese individuals were collected and used for genotyping for variant rs35767: T > C in the IGF-1 upstream promoter. Data were analyzed to identify associations between IGF-1 genotypes and patient biochemical parameters, including the components of metabolic syndrome and the long-term change in renal function. Results The cohort rs35767 genotypes included 650 CC carriers (43.2%), 687 TC carriers (45.6%), and 169 TT carriers (11.2%). Multiple regression analysis revealed no association between IGF-1 genotype and blood pressure, glycated hemoglobin level, and serum uric acid level. However, in females, blood pressure was negatively correlated with the TT genotype. Longitudinal observation revealed that the decline in eGFR over 10 years was greater in TT (− 18.51 ± 1.04 mL/min/1.73m2) than in CC carriers (− 16.38 ± 0.52 mL/min/1.73m2; P < 0.05). Conclusion The present study suggests that renal function declines faster in individuals with the TT genotype at the IGF-1 rs35767 locus than in those with the CC genotype, suggesting that the TT genotype is associated with the long-term chronological decline in renal function.

Mo2035 Acute Salmonella Gastroenteritis Occurring Early in Life but Not in Adulthood Is a Risk Factor for Post-Infectious Irritable Bowel Syndrome (PI-IBS) in the Long Term

2013 ◽  
Vol 144 (5) ◽  
pp. S-724 ◽  
Author(s):  
Cesare Cremon ◽  
Francesca Pallotti ◽  
Antonio M. Morselli-Labate ◽  
Alexandro Paccapelo ◽  
Lara Bellacosa ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Risk Factor ◽  
Irritable Bowel ◽  
Post Infectious

Gestational diabetes and the long-term risk of cataract surgery: A longitudinal cohort study

2017 ◽  
Vol 31 (11) ◽  
pp. 1565-1570 ◽  
Author(s):  
Nathalie Auger ◽  
Tina Tang ◽  
Jessica Healy-Profitós ◽  
Gilles Paradis
Keyword(s):  
Cohort Study ◽  
Gestational Diabetes ◽  
Cataract Surgery ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

scholarly journals Pain as a risk factor for suicidal ideation. A population-based longitudinal cohort study

2020 ◽  
Vol 63 ◽  
pp. 54-61 ◽  
Author(s):  
Eric W. de Heer ◽  
Margreet ten Have ◽  
Harm W.J. van Marwijk ◽  
Jack Dekker ◽  
Ron de Graaf ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Suicidal Ideation ◽  
Population Based ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

scholarly journals Long-term distress in older patients with cancer: a longitudinal cohort study

BJGP Open ◽  
2019 ◽  
Vol 3 (3) ◽  
pp. bjgpopen19X101658 ◽  
Author(s):  
Stephanie Dauphin ◽  
Leontien Jansen ◽  
Tine De Burghgraeve ◽  
Laura Deckx ◽  
Frank Buntinx ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Diagnosis ◽  
Older Patients ◽  
Contact Point ◽  
Longitudinal Cohort Study ◽  
Aged Patients ◽  
Major Life ◽  
Longitudinal Cohort ◽  
Patients With Cancer

BackgroundReceiving a cancer diagnosis can be a major life event which causes distress even years after primary treatment.AimTo examine the prevalence of distress in older patients with cancer (OPCs) up until 5 years post-diagnosis, and identify predictors present at time of diagnosis. Results are compared with reference groups of middle-aged patients with cancer (MPCs) and older patients without a cancer diagnosis (OPs).Design & settingOPCs, MPCs, and OPs participated in a longitudinal cohort study in Belgium and the Netherlands by filling in questionnaires at designated time points from 2010–2019.MethodData from 541 patients were analysed using multivariable logistic regression analyses.ResultsAt baseline, 40% of OPCs, 37% of MPCs, and 17% of OPs reported distress. After 5 years, 35% of OPCs, 23% of MPCs, and 25% of OPs reported distress. No significant predictors for long-term distress in OPCs and OPs were found. For MPCs, it was found that baseline distress (odds ratio [OR] 2.94; 95% confidence intervals [CI] = 1.40 to 6.19) and baseline fatigue (OR 4.71; 95% CI = 1.81 to 12.31) predicted long-term distress.ConclusionDistress is an important problem for people with cancer, with peaks at different moments after diagnosis. Feelings of distress are present shortly after diagnosis but they decrease quickly for the majority of patients. In the long term, however, OPCs in particular appear to be most at risk for distress. This warrants extra attention from primary healthcare professionals, such as GPs who are often patients’ first medical contact point. More research into risk factors occurring later in an illness trajectory might shed more light on predictors for development of long-term distress.

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