scholarly journals Diffuse Normolipemic Plane Xanthomatosis with Immunoglobulin-Lambda Light-Chain Deposition in a Patient with Multiple Myeloma

2019 ◽  
Vol 31 (2) ◽  
pp. 238
Author(s):  
Sul Hee Lee ◽  
Ji Yeoun Shin ◽  
Sang-Hoon Lee ◽  
Young Lip Park
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Lambda Light Chain ◽  
Light Chain Deposition ◽  
Immunoglobulin Lambda

Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review

2016 ◽  
Vol 25 (1) ◽  
pp. 99-103 ◽  
Author(s):  
Benoit Brilland ◽  
Johnny Sayegh ◽  
Anne Croue ◽  
Frank Bridoux ◽  
Jean-François Subra ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Intrahepatic Cholestasis ◽  
Relevant Literature ◽  
Gamma Glutamyl Transferase ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Uncommon Presentation ◽  
Light Chain Deposition ◽  
Glutamyl Transferase

Light chain deposition disease (LCDD) is a rare multisystemic disorder associated with plasma cell proliferation. It mainly affects the kidney, but liver and heart involvement may occur, sometimes mimicking the picture of systemic amyloidosis. Liver disease in LCDD is usually asymptomatic and exceptionally manifests with severe cholestatic hepatitis. We report the case of a 66-year-old female with κ-LCDD and cast nephropathy in the setting of symptomatic multiple myeloma who, after a first cycle of bortezomib-dexamethasone chemotherapy, developed severe and rapidly worsening intrahepatic cholestasis secondary to liver κ-light chain deposition. Intrahepatic cholestasis was attributed to LCDD on the basis of the liver histology and exclusion of possible diagnoses. Chemotherapy was maintained and resulted in progressive resolution of cholestasis. We report here an uncommon presentation of LCDD, with prominent liver involvement that fully recovered with bortezomib-based chemotherapy, and briefly review the relevant literature. Abbreviations: AKI: Acute kidney injury; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; CMV: Cytomegalovirus; EBV: Epstein–Barr virus; GGT: gamma-glutamyl transferase; HSV: Herpes simplex virus; LC: light chain; LCDD: Light chain deposition disease; MIDD: Monoclonal immunoglobulin deposition disease; MM: Multiple myeloma.

scholarly journals Systemic lambda light-chain deposition in a patient with myeloma.

BMJ ◽  
1981 ◽  
Vol 282 (6265) ◽  
pp. 681-683 ◽  
Author(s):  
D Ganeval ◽  
L H Noel ◽  
D Droz ◽  
J Leibowitch
Keyword(s):  
Light Chain ◽  
Lambda Light Chain ◽  
Light Chain Deposition

scholarly journals Clinical characteristics and prognostic factors in multiple myeloma patients with light chain deposition disease

2017 ◽  
Vol 92 (8) ◽  
pp. 739-745 ◽  
Author(s):  
Meera Mohan ◽  
Amy Buros ◽  
Pankaj Mathur ◽  
Neriman Gokden ◽  
Manisha Singh ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Prognostic Factors ◽  
Light Chain ◽  
Clinical Characteristics ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition

Systemic kappa light chain deposition and amyloidosis in multiple myeloma: novel morphological observations

1986 ◽  
Vol 10 (10) ◽  
pp. 1065-1076 ◽  
Author(s):  
C.J. KIRKPATRICK ◽  
A. CURRY ◽  
J. GALLE ◽  
I. MELZNER
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Kappa Light Chain ◽  
Light Chain Deposition

Allelic polymorphisms and RFLP in the human immunoglobulin lambda light chain locus

1999 ◽  
Vol 104 (5) ◽  
pp. 361-369 ◽  
Author(s):  
Marie-Paule Lefranc ◽  
Nathalie Pallarès ◽  
Jean-Pol Frippiat
Keyword(s):  
Light Chain ◽  
Human Immunoglobulin ◽  
Lambda Light Chain ◽  
Chain Locus ◽  
Light Chain Locus ◽  
Immunoglobulin Lambda

scholarly journals Lambda light chain deposition disease presenting as sicca syndrome

1997 ◽  
Vol 40 (3) ◽  
pp. 587-588 ◽  
Author(s):  
Mohamed A. Hamidou ◽  
Christelle Gires ◽  
Anne Moreau ◽  
Stéphane Martin ◽  
Françoise Buzelin ◽  
...  
Keyword(s):  
Light Chain ◽  
Sicca Syndrome ◽  
Lambda Light Chain ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition

scholarly journals Renal Tubular Acidosis type II Secondary to .LAMBDA.-Light Chain Excretion in an Elderly Patient with Multiple Myeloma.

1998 ◽  
Vol 35 (6) ◽  
pp. 477-481
Author(s):  
Kent Doi ◽  
Shinji Teramoto ◽  
Takayuki Hosoi ◽  
Mariko Miyao ◽  
Takeshi Matsuse ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Multiple Myeloma ◽  
Light Chain ◽  
Renal Tubular Acidosis ◽  
Type Ii ◽  
Lambda Light Chain ◽  
Renal Tubular
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