scholarly journals Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study

2016 ◽  
Vol 28 (6) ◽  
pp. 733 ◽  
Author(s):  
Hae Jeong Youn ◽  
Soo Young Kim ◽  
Minji Park ◽  
Won Hee Jung ◽  
Yang Won Lee ◽  
...  
Keyword(s):  
Clinical Study ◽  
Seborrheic Dermatitis ◽  
Efficacy And Safety ◽  
Single Center ◽  
Open Label ◽  
Split Face

The efficacy and safety of dydrogesterone for treatment of dysmenorrhea: An open-label multicenter clinical study

2018 ◽  
Vol 45 (1) ◽  
pp. 168-175
Author(s):  
Fuminori Taniguchi ◽  
Ikuko Ota ◽  
Yumiko Iba ◽  
Toshiko Toda ◽  
Yukiko Tagashira ◽  
...  
Keyword(s):  
Clinical Study ◽  
Efficacy And Safety ◽  
Open Label ◽  
Multicenter Clinical Study

Combining radiation therapy with anti-PD-1 for patients with advanced hepatocellular carcinoma: An open-label, single-center, single-arm clinical study.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16117-e16117
Author(s):  
Jian-Xu Li ◽  
Ting-Shi Su ◽  
Xiao-Feng Lin ◽  
Yi-Tian Chen ◽  
Shi-Xiong Liang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Trial ◽  
Radiation Therapy ◽  
Clinical Study ◽  
Cancer Staging ◽  
Advanced Hepatocellular Carcinoma ◽  
Single Center ◽  
Open Label ◽  
Grade 3 ◽  
Clinical Trial Information

e16117 Combining radiation therapy with anti-PD-1 for patients with advanced hepatocellular carcinoma: an open-label, single-center, single-arm clinical study Jian-Xu Li, Ting-Shi Su, Xiao-Feng Lin, Yi-Tian Chen, Shi-Xiong Liang, Bang-De Xiang; Guangxi Medical University Cancer Hospital, Nanning, China Abstract Research Funding: Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, China. Guangxi Medical and Health Appropriate Technology Development and Application Project (No. S2019039), Guangxi, China. Background: Based on the results of recent studies, the PD-1 monoclonal antibodies have been approved to treat the patients with advanced hepatocellular carcinoma (HCC) by the FDA. Radiation therapy (RT) can enhance responsiveness to PD-1 monoclonal antibody by potential mechanisms. A phase Ⅱa study was conducted to assess the safety and the efficacy of combining RT with anti-PD-1 for patients with advanced hepatocellular carcinoma. Methods: Patients with advanced HCC were eligible. Stereotactic body radiation therapy (SBRT) were adopted, and the dose of radiation were Dt-PGTV 30-50 Gy/10fractions. Camrelizumab (200mg) were given intravenously every 3 weeks since the first day of RT until disease progression, or intolerable toxicity. Adverse events (AEs) and objective response rate (ORR) were summarized to assess the safety and efficacy. Results: From April 2020 to November 2020, 17 patients were enrolled (median age 54, range 32-69). 15 (88%) patients were male. 14 (82%) had ECOG performance score of 0. All the patients had Child-Pugh score A. 16 patients staged as Barcelona Clinic Liver Cancer staging C or China Liver Cancer staging Ⅲ. Extrahepatic metastases were identified in 11 (65%) patients. 13 (77%) patients were Hepatitis B virus infected. 15 (88%) patients had previously 2 lines or more chemotherapy. 9 (53%) patients had Alpha-fetoprotein level≥400 ng/ml. The ORR was 47%. The best response assessed by RECIST 1.1 was partial response (8 patients). Four patients had grade 3 immune-related adverse events (irAEs), including increased aspartate aminotransferase and alanine transaminase (n =1)，decreased hemoglobin (n =1)，decreased platelet count (n =1)，decreased neutrophil count (n =1). All grade 3 irAEs were mitigated with proper treatment. None treatment-related deaths occurred. Conclusions: In this study, RT combined with anti-PD-1 had an acceptable safety profile and indicated an effective treatment option in patients with unresectable HCC. Clinical trial information: NCT04193696. Clinical trial information: NCT04193696.

scholarly journals Treatment of Facial Seborrheic Dermatitis with Pimecrolimus Cream 1%: An Open-Label Clinical Study in Korean Patients

2007 ◽  
Vol 22 (5) ◽  
pp. 868 ◽  
Author(s):  
Byung-Soo Kim ◽  
Su-Han Kim ◽  
Moon-Bum Kim ◽  
Chang-Keun Oh ◽  
Ho-Sun Jang ◽  
...  
Keyword(s):  
Clinical Study ◽  
Seborrheic Dermatitis ◽  
Open Label ◽  
Korean Patients

Clinical Study to Evaluate the Efficacy and Safety of Comprehensive Ayurvedic Therapy in Plaque Psoriasis: An Open-label Multicentric Prospective Study

2019 ◽  
Vol 3 (2) ◽  
pp. 39-47
Author(s):  
Narayanam Srikanth ◽  
Shruti Khanduri ◽  
Rakesh Rana ◽  
Kartar Singh Dhiman ◽  
Sophia Jameela ◽  
...  
Keyword(s):  
Clinical Study ◽  
Prospective Study ◽  
Plaque Psoriasis ◽  
Efficacy And Safety ◽  
Open Label
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