scholarly journals Application of Topical Acids Improves Atopic Dermatitis in Murine Model by Enhancement of Skin Barrier Functions Regardless of the Origin of Acids

2016 ◽  
Vol 28 (6) ◽  
pp. 690 ◽  
Author(s):  
Noo Ri Lee ◽  
Hae-Jin Lee ◽  
Na Young Yoon ◽  
Donghye Kim ◽  
Minyoung Jung ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Murine Model ◽  
Skin Barrier ◽  
Barrier Functions

scholarly journals The Suppressive Effect of Leucine-Rich Glioma Inactivated 3 (LGI3) Peptide on Impaired Skin Barrier Function in a Murine Model Atopic Dermatitis

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 750
Author(s):  
Ui Seok Kim ◽  
Jin Woo Park ◽  
Eon Sub Park ◽  
Joon Seok Bang ◽  
Tae Woo Jung ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Murine Model ◽  
Barrier Function ◽  
Skin Barrier ◽  
Clinical Score ◽  
Skin Lesions ◽  
Suppressive Effect ◽  
Skin Barrier Function ◽  
Skin Thickness ◽  
Dorsal Skin

This study aimed to restore the skin barrier function from atopic dermatitis (AD) via treatment with leucine-rich glioma inactivated 3 (LGI3) peptide. Male NC/Nga mice (7 weeks, 20 g) were randomly allocated into three groups (control, AD, and LGI3 group). After induction of AD skin lesions with Dermatophagoides farinae ointment, mice were treated with LGI3. The clinical score of AD was the highest and the dorsal skin thickness was the thickest in the AD group. In contrast, LGI3 treatment improved the clinical score and the dorsal skin thickness compared to the AD model. LGI3 treatment suppressed histopathological thickness of the epithelial cell layer of the dorsal skin. LGI3 treatment could indirectly reduce mast cell infiltration through restoring the barrier function of the skin. Additionally, the filaggrin expression was increased in immunohistochemical evaluation. In conclusion, the ameliorating effect and maintaining skin barrier homeostasis in the AD murine model treated with LGI3 could be attributed to complete re-epithelialization of keratinocytes. Hence, LGI3 might be considered as a new potential therapeutic target for restoring skin barrier function in AD.

scholarly journals 43 Role of Sweating on Impaired Skin Barrier Functions in Atopic Dermatitis

2012 ◽  
Vol 5 ◽  
pp. S14-S15
Author(s):  
Aya Takahashi ◽  
Akihiro Kimura Student ◽  
Saki Matsui ◽  
Akiko Kijima ◽  
Shun Kitaba ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Barrier Functions

Dynamic Trends in Skin Barrier Function From Birth to Age 6 Months and Infantile Atopic Dermatitis: A Chinese Prospective Cohort Study

2020 ◽  
Author(s):  
Ying Ye ◽  
Piaoping Zhao ◽  
Limin Dou ◽  
Yi Zhang ◽  
Kaku Ken ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Prospective Cohort ◽  
Early Life ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Delivery Mode ◽  
Term Infants ◽  
Parental History ◽  
Barrier Functions ◽  
Skin Ph

Abstract BackgroundSkin barrier functions develop after birth and may be related to skin disorders in infants. ObjectivesWe aimed to assess associations between dynamic trends of four skin barrier functional parameters in early life with infant atopic dermatitis (AD).MethodsBased on the prospective cohort MKNFOAD (NCT02889081), we examined transepidermal water loss (TEWL), stratum corneum hydration (SCH), skin pH, and sebum content at five anatomical sites (cheek, forehead, forearm, abdomen, and lower leg) in 418 term infants at birth, 42 days, and 6 months. Trend differences by sex and association with AD at age 1 year were tested using variance analyses. Associations of the parameters with AD risk were tested using discrete time survival analysis, adjusting extensive covariates including parental history of allergy, infant’s sex, birth weight (kg), and delivery mode. Odds ratios (ORs) and 95% confidence interval (CIs) were reported.ResultsOverall TEWL and SCH appeared trends of increase while skin surface pH and sebum content showed trends of decrease within the first 6 postnatal months. Sex differences were significant for sebum content only (p<0.001). After adjustment for parental and children covariates, cheek TEWL (OR=1.26, 95% CI 1.00–1.57, p=0.045) at birth and 42 days (OR=1.52, 95% CI 1.17–1.97, p=0.002) were significantly associated with increased AD risk. Associations were not observed between SCH, skin pH, and sebum content at birth or 42 days with AD. ConclusionsSkin barrier functions of Chinese term infants varied nonlinearly after birth. Higher postnatal TEWL levels in early life indicate higher risk of early-onset AD.

scholarly journals Evaluation of selected skin barrier functions in atopic dermatitis in relation to the disease severity and pruritus

2012 ◽  
Vol 5 ◽  
pp. 373-377 ◽  
Author(s):  
Adriana Polańska ◽  
Aleksandra Dańczak-Pazdrowska ◽  
Wojciech Silny ◽  
Dorota Jenerowicz ◽  
Agnieszka Osmola-Mańkowska ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Skin Barrier ◽  
Barrier Functions
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