scholarly journals Pilot Study of the Efficacy of 578 nm Copper Bromide Laser Combined with Intralesional Corticosteroid Injection for Treatment of Keloids and Hypertrophic Scars

2014 ◽  
Vol 26 (2) ◽  
pp. 156 ◽  
Author(s):  
In Pyeong Son ◽  
Kui Young Park ◽  
Beomjoon Kim ◽  
Myeung Nam Kim
Keyword(s):  
Pilot Study ◽  
Corticosteroid Injection ◽  
Hypertrophic Scars ◽  
Copper Bromide ◽  
Intralesional Corticosteroid ◽  
Copper Bromide Laser

scholarly journals Corticosteroid Injection Alone or Combined with Surgical Excision of Keloids versus Other Therapies Including Ionising Radiotherapy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

2021 ◽  
Vol 2 (2) ◽  
pp. 41-54
Author(s):  
Ru Wang ◽  
Patricia L. Danielsen ◽  
Magnus S. Ågren ◽  
Janine Duke ◽  
Fiona Wood ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomised Controlled Trials ◽  
Corticosteroid Injection ◽  
Meta Analysis ◽  
Interferon Α ◽  
Surgical Removal ◽  
Controlled Trials ◽  
Intralesional Corticosteroid ◽  
Intralesional Injections ◽  
Randomised Controlled

Keloid scars are difficult to manage and remain a therapeutic challenge. Corticosteroid therapy alone or ionising radiation (radiotherapy) alone or combined with surgery are first-line treatments, but the scientific justification for these treatments is unclear. The aim of this systematic review and meta-analysis of randomised controlled trials (RCTs) is to assess the effects of intralesional corticosteroid injection in treating keloids or preventing their recurrence after surgical removal. Searches for RCTs were conducted through the MEDLINE, EMBASE, EBSCO and Cochrane databases from January 1974 to September 2017. Two authors independently reviewed study eligibility, extracted data, analysed the results, and assessed methodological quality. Sixteen RCTs that included more than 814 patients were scrutinised. The quality of evidence for most outcomes was moderate to high. In 10 RCTs, corticosteroid intralesional injections were compared with 5-fluorouracil, etanercept, cryosurgery, botulinum toxin, topical corticosteroid under a silicone dressing, and radiotherapy. Corticosteroid intralesional injections were more effective than radiotherapy (RR 3.3, 95% CI: 1.4–8.1) but equipotent with the other interventions. In conjunction with keloid excision, corticosteroid treatment was compared with radiotherapy, interferon α-2b and verapamil. In two RCTs, there were fewer keloid recurrences (RR 0.43, 95% CI: 0.21–0.89) demonstrated with adjuvant radiotherapy than with corticosteroid injections. More high-quality, large-scale RCTs are required to establish the effectiveness of corticosteroids and other therapies in keloid management.

scholarly journals Unsuccessful Treatment of Cheilitis Granulomatosa with Oral Methotrexate

2019 ◽  
Vol 11 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Thanapon Sutharaphan ◽  
Kumutnart Chanprapaph ◽  
Vasanop Vachiramon
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Case Reports ◽  
Corticosteroid Injection ◽  
Granulomatous Inflammation ◽  
Spontaneous Remission ◽  
Expert Opinions ◽  
Cheilitis Granulomatosa ◽  
Unsuccessful Treatment ◽  
Intralesional Corticosteroid

Cheilitis granulomatosa (CG) is a rare idiopathic condition with painless lip swelling, characterized by non-necrotizing granulomatous inflammation in the absence of other identifiable causes such as Crohn’s disease, sarcoidosis, foreign body reaction, or infection. CG may precede the presentation of Crohn’s disease after long-term follow-up. Spontaneous remission of CG rarely occurs. To date, given the rarity of CG, there is no gold standard treatment. Recommended treatments are supported by small studies, case reports/series, and expert opinions. Glucocorticoids are the first-line therapy in the acute stages of the disease; however, recurrence commonly occurs. Previously, methotrexate (MTX) showed a beneficial effect on orofacial swelling in a case of CG accompanied by Crohn’s disease. We present a patient with CG without Crohn’s disease. He was treated with oral MTX in combination with intralesional corticosteroid injection on one side of the lip. The injected side showed improvement, while lip swelling on the noninjected area remained unchanged after 3 months of treatment. Therefore, CG is refractory to treatment with MTX from our experience. Further studies regarding the optimum dosage of MTX is needed.

Pressure Dependence of the Small-Signal Gain and Saturation Intensity of a Copper Bromide Laser

2017 ◽  
Vol 34 (8) ◽  
pp. 084201 ◽  
Author(s):  
M. E. Aeinehvand ◽  
S. Behrouzinia ◽  
M. K. Salem ◽  
M. Elahei ◽  
K. Khorasani
Keyword(s):  
Pressure Dependence ◽  
Small Signal Gain ◽  
Small Signal ◽  
Signal Gain ◽  
Copper Bromide ◽  
Saturation Intensity ◽  
Copper Bromide Laser

KELOIDS AND HYPERTROPHIC SCARS: RESULTS WITH INTRA-OPERATIVE AND SERIAL POSTOPERATIVE CORTICOSTEROID INJECTION THERAPY

1999 ◽  
Vol 69 (9) ◽  
pp. 655-659 ◽  
Author(s):  
Nisar Ahmad Chowdri ◽  
Mohammad Masarat Ajaz Mattoo ◽  
Mohammad Ashraf Darzi
Keyword(s):  
Corticosteroid Injection ◽  
Injection Therapy ◽  
Hypertrophic Scars
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