scholarly journals A Case of Primary Cutaneous Mucinous Carcinoma with Neuroendocrine Differentiation

2010 ◽  
Vol 22 (4) ◽  
pp. 472 ◽  
Author(s):  
June-Bum Kim ◽  
Ji-Hyun Choi ◽  
Ji-Hye Kim ◽  
Hyang-Joon Park ◽  
Jae-Seung Lee ◽  
...  
Keyword(s):  
Neuroendocrine Differentiation ◽  
Mucinous Carcinoma

scholarly journals Neuroendocrine differentiation in pure type mammary mucinous carcinoma is associated with favorable histologic and immunohistochemical parameters

2004 ◽  
Vol 17 (5) ◽  
pp. 568-572 ◽  
Author(s):  
Gary M K Tse ◽  
Tony K F Ma ◽  
Winnie C W Chu ◽  
Wynnie W M Lam ◽  
Cycles S P Poon ◽  
...  
Keyword(s):  
Neuroendocrine Differentiation ◽  
Mucinous Carcinoma ◽  
Pure Type

Mucinous carcinoma of the breast: a comparative study on cytohistological findings associated with neuroendocrine differentiation

Cytopathology ◽  
2016 ◽  
Vol 27 (3) ◽  
pp. 193-200 ◽  
Author(s):  
R. Ohashi ◽  
T. Sakatani ◽  
M. Matsubara ◽  
Y. Watarai ◽  
K. Yanagihara ◽  
...  
Keyword(s):  
Comparative Study ◽  
Neuroendocrine Differentiation ◽  
Mucinous Carcinoma ◽  
Carcinoma Of The Breast

scholarly journals Diagnostic and Pathologic Value of Programmed Death-Ligand 1 Expression in Colon Carcinoma

2020 ◽  
Vol 5 (4) ◽  
pp. 159-166
Author(s):  
Dina Omar Helmy ◽  
Mahmoud Tag El-Sabah ◽  
Mohamed Sherif Negm ◽  
Mina Ezzat Onsy Armia
Keyword(s):  
Colon Carcinoma ◽  
Large Scale ◽  
Neuroendocrine Differentiation ◽  
Personal Data ◽  
Mucinous Carcinoma ◽  
Tumor Type ◽  
Invasive Adenocarcinoma ◽  
Male Predominance ◽  
Programmed Death ◽  
Score Method

Objectives: To evaluate the diagnostic value of programmed death-ligand1 expression in colon carcinoma cells and its correlation with different pathological features. Methods: An immunohistochemical study was conducted on 50 cases diagnosed as colon carcinoma over a one year period from October 2018 to October 2019.The paraffin blocks were received from the Pathology Departments, Faculty of Medicine, Cairo University and Misr University for Science and Technology (MUST). The diagnosis of colon carcinoma for all cases was revised using H&E stain. The immunohistochemical expression of programmed death- ligand1 was assessed using immune reactive score method. The personal data, clinical details and pathological diagnosis were recorded and correlated with programmed death-ligand1 expression. Results: This study included 50 cases of colon carcinoma. There was a male predominance with female to male ratio 1:1.08.The age of patients was ranged from 30 years to 76 years with mean age 53.3± 11.2 years. The majority of cases (44%) were invasive adenocarcinoma followed by invasive adenocarcinoma with mucoid activity (18%), invasive adenocarcinoma with neuroendocrine differentiation (16%), invasive signet ring carcinoma (14%) and invasive mucinous carcinoma (8%). Immune reactive score for programmed death-ligand1 had a Mean ± Standard Deviation of 8.4 ± 4.2. Strong immune reactive score was represented by 58% of cases, moderate immune reactive score was represented by 24% of cases and only one case (2%) had mild immune reactive score. The remaining 16% of cases were negative. Correlation between immune reactive score of programmed death-ligand1and tumor type, size and lymph-vascular invasion was statistically significant. Cases with marked immune reactive score for programmed death-ligand1 showed highest predilection for invasive adenocarcinoma with neuroendocrine differentiation, large sized tumors and lymph-vascular invasion.Conclusion: The expression of programmed death-ligand1 using immune reactive score method can estimate the growth of colon carcinoma, invasive adenocarcinoma with neuroendocrine differentiation and lymph-vascular spread. Further large scale studies utilizing programmed death-ligand 1can aid in identifying the prognosis and therapeutic possibilities for patients with colon cancer.

Mucinous carcinoma of the breast with neuroendocrine differentiation

2000 ◽  
Vol 50 (8) ◽  
pp. 644-648 ◽  
Author(s):  
Hiroyuki Nakagawa ◽  
Nobuaki Shikata ◽  
Hideto Senzaki ◽  
Yoshiko Uemura ◽  
Tomoo Inoue ◽  
...  
Keyword(s):  
Neuroendocrine Differentiation ◽  
Mucinous Carcinoma ◽  
Carcinoma Of The Breast

Recurrent primary cutaneous mucinous carcinoma with neuroendocrine differentiation: case report and review of the literature

2014 ◽  
Vol 41 (8) ◽  
pp. 686-691 ◽  
Author(s):  
Elodie Miquelestorena-Standley ◽  
Fanny Dujardin ◽  
Flavie Arbion ◽  
Antoine Touzé ◽  
Laurent Machet ◽  
...  
Keyword(s):  
Case Report ◽  
Neuroendocrine Differentiation ◽  
Mucinous Carcinoma ◽  
Review Of The Literature

scholarly journals Mucinous Carcinoma with Neuroendocrine Differentiation of Salivary Gland Origin

2016 ◽  
Vol 11 (2) ◽  
pp. 249-255 ◽  
Author(s):  
Frankie K. Wong ◽  
Zachary S. Zumsteg ◽  
Claude-Jean Langevin ◽  
Nabilah Ali ◽  
Shawn Maclary ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Neuroendocrine Differentiation ◽  
Mucinous Carcinoma

Ultrastructural Localization Study of Carcinoembryonic Antigen (CEA) in Gastric Cancer: Immunoelectron Microscopic Observation

1990 ◽  
Vol 48 (3) ◽  
pp. 252-253
Author(s):  
Dong Yuming ◽  
Yang Guanglin ◽  
Wu Jifeng ◽  
Chen Xiaolin
Keyword(s):  
Gastric Cancer ◽  
Intestinal Metaplasia ◽  
Cancer Cells ◽  
Microscopic Observation ◽  
Biological Significance ◽  
Ultrastructural Localization ◽  
Mucinous Carcinoma ◽  
Surface Glycoprotein ◽  
Tubular Adenocarcinoma ◽  
Pap Method

On the basis of light microscopic observation, the ultrastructural localization of CEA in gastric cancer was studied by immunoelectron microscopic technique. The distribution of CEA in gastric cancer and its biological significance and the mechanism of abnormal distribution of CEA were further discussed.Among 104 surgically resected specimens of gastric cancer with PAP method at light microscopic level, the incidence of CEA(+) was 85.58%. All of mucinous carcinoma exhibited CEA(+). In tubular adenocarcinoma the incidence of CEA(+) showed a tendency to rising with the increase of degree of differentiation. In normal epithelia and intestinal metaplasia CEA was faintly present and was found only in the luminal surface. The CEA staining patterns in cancer cells were of three types--- cytoplasmic, membranous and weak reactive type. The ultrastructural localization of CEA in 14 cases of gastric cancer was studied by immunoelectron microscopic technique.There was a little or no CEA in the microvilli of normal epithelia. In intestinal metaplasia CEA was found on the microvilli of absorptive cells and among the mucus particles of goblet cells. In gastric cancer CEA was also distributed on the lateral and basal surface or even over the entire surface of cancer cells and lost their polarity completely. Many studies had proved that the alterations in surface glycoprotein were characteristic changes of tumor cells. The antigenic determinant of CEA was glycoprotein, so the alterations of tumor-associated surface glycoprotein opened up a new way for the diagnosis of tumors.

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