scholarly journals Quantitative Determination of Nicotine in a PDMS Microfluidic Channel Using Surface Enhanced Raman Spectroscopy

2006 ◽  
Vol 27 (2) ◽  
pp. 277-280 ◽  
Keyword(s):  
Raman Spectroscopy ◽  
Quantitative Determination ◽  
Microfluidic Channel ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Qualitative and quantitative determination of coumarin using surface-enhanced Raman spectroscopy coupled with intelligent multivariate analysis

RSC Advances ◽  
2017 ◽  
Vol 7 (77) ◽  
pp. 49097-49101 ◽  
Author(s):  
J. Huang ◽  
P. Liang ◽  
J. Xu ◽  
Y. Wu ◽  
W. Shen ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Multivariate Analysis ◽  
Quantitative Determination ◽  
Surface Enhanced Raman Spectroscopy ◽  
Qualitative And Quantitative ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Coumarin is harmful to health but still used in cosmetics, tobacco, or illegally added into food as a spice in trace amounts so that it is exceedingly difficult to be determined accurately.

Feasibility of quantitative determination of doxorubicin with surface-enhanced Raman spectroscopy

2001 ◽  
Vol 32 (11) ◽  
pp. 971-974 ◽  
Author(s):  
A. Lorén ◽  
C. Eliasson ◽  
M. Josefson ◽  
K. V. G. K. Murty ◽  
M. Käll ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Quantitative Determination ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Multivariate Analysis Aided Surface-Enhanced Raman Spectroscopy (MVA-SERS) Multiplex Quantitative Detection of Trace Fentanyl in Illicit Drug Mixtures Using a Handheld Raman Spectrometer

2021 ◽  
pp. 000370282110329
Author(s):  
Ling Wang ◽  
Mario O. Vendrell-Dones ◽  
Chiara Deriu ◽  
Sevde Doğruer ◽  
Peter de B. Harrington ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Principal Component ◽  
Surface Enhanced Raman Spectroscopy ◽  
Quantitative Detection ◽  
Least Squares Regression ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Current Screening

Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl. Surface-enhanced Raman spectroscopy (SERS) provides a useful alternative to current screening procedures that permits detection of trace levels of fentanyl in mixtures. Samples are solubilized and allowed to interact with aggregated colloidal nanostars to produce a rapid and sensitive assay. In this study, we present the quantitative determination of fentanyl in heroin and cocaine using SERS, using a point-and-shoot handheld Raman system. Our protocol is optimized to detect pure fentanyl down to 0.20 ± 0.06 ng/mL and can also distinguish pure cocaine and heroin at ng/mL levels. Multiplex analysis of mixtures is enabled by combining SERS detection with principal component analysis and super partial least squares regression discriminate analysis (SPLS-DA), which allow for the determination of fentanyl as low as 0.05% in simulated seized heroin and 0.10% in simulated seized cocaine samples.

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