scholarly journals CDX-1/CDX-2 Expression Is a Favorable Prognostic Factor in Epstein-Barr Virus-Negative, Mismatch Repair-Proficient Advanced Gastric Cancers

Gut and Liver ◽  
2021 ◽  
Author(s):  
Kyeongmin Kim ◽  
Songmi Noh ◽  
Jae-Ho Cheong ◽  
Hyunki Kim
Keyword(s):  
Prognostic Factor ◽  
Mismatch Repair ◽  
Epstein Barr Virus ◽  
Gastric Cancers ◽  
Barr Virus ◽  
Favorable Prognostic Factor ◽  
Epstein Barr

scholarly journals Low PD-L1 Expression Strongly Correlates with Local Recurrence in Epstein-Barr Virus-Positive Nasopharyngeal Carcinoma after Radiation-Based Therapy

Cancers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 374 ◽  
Author(s):  
Yu-Jen Liu ◽  
Ngan-Ming Tsang ◽  
Chuen Hsueh ◽  
Chi-Ju Yeh ◽  
Shir-Hwa Ueng ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Nasopharyngeal Carcinoma ◽  
Local Recurrence ◽  
Epstein Barr Virus ◽  
Disease Free Survival ◽  
Concurrent Chemotherapy ◽  
Barr Virus ◽  
Programmed Death ◽  
Favorable Prognostic Factor ◽  
Epstein Barr

The prognostic value of programmed death-ligand 1 (PD-L1) expression in nasopharyngeal carcinoma (NPC) is controversial, with previous studies showing conflicting results. Most NPCs in endemic areas are Epstein-Barr virus (EBV)-positive. Our aim was to evaluate the clinical significance of PD-L1 expression in EBV-positive NPC. We retrospectively analyzed PD-L1 expression on tumor cells (TCs) and immune cells (ICs) by immunohistochemistry in 208 EBV-positive NPC patients who underwent radiotherapy (203 with concurrent chemotherapy). The percentages of TCs and ICs expressing PD-L1 were evaluated respectively. There was a strong correlation between local recurrence and low PD-L1 expression on ICs (p = 0.0012), TCs (p = 0.013) or both (p = 0.000044), whereas all clinical parameters had no influence on local recurrence. Using multivariate analysis, low PD-L1 expression on ICs was an independent adverse prognostic factor (p = 0.0080; HR = 1.88; 95% CI = 1.18–3.00) for disease-free survival. High PD-L1 expression on both ICs and TCs was an independent favorable prognostic factor (p = 0.022; HR = 0.46; 95% CI = 0.24–0.89) for overall survival. We show for the first time that low PD-L1 expression on ICs and TCs strongly correlates with local recurrence in EBV-positive NPC patients after radiation-based therapy. A simple immunohistochemical study for PD-L1 can identify patients prone to local recurrence, and such patients might benefit from more aggressive treatment in future clinical trials.

Comparison of Clinicopathologic Parameters and Survivals Between Epstein-Barr Virus–positive and Her2-positive Gastric Cancers

2017 ◽  
Vol 25 (9) ◽  
pp. 609-614 ◽  
Author(s):  
Cigdem Irkkan ◽  
Serdar Balci ◽  
Gaye Güler Tezel ◽  
Bülent Akinci ◽  
Bülent Yalcin ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Her2 Positive ◽  
Gastric Cancers ◽  
Barr Virus ◽  
Clinicopathologic Parameters ◽  
Epstein Barr

PD-L1 expression in Epstein-Barr virus-infected gastric cancers.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 4052-4052 ◽  
Author(s):  
Sarah Derks ◽  
Xiaoyun Liao ◽  
Xinsen Xu ◽  
M. Constanza Camargo ◽  
Anna M Chiaravalli ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Gastric Cancers ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Epstein–Barr virus DNA level as a novel prognostic factor in nasopharyngeal carcinoma

Medicine ◽  
2016 ◽  
Vol 95 (40) ◽  
pp. e5130 ◽  
Author(s):  
Jing Zhang ◽  
Chi Shu ◽  
Yanlin Song ◽  
Qingfang Li ◽  
Jingwen Huang ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

Serologically positive gastric cancers associated with Epstein-Barr virus

2021 ◽  
Vol 24 (3) ◽  
pp. 77
Author(s):  
I.I. Alentov ◽  
A.V. Chaika ◽  
V.Yu. Skoropad ◽  
V.M. Khomyakov ◽  
S.S. Pirogov ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Gastric Cancers ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Preservation of Epstein–Barr virus status and mismatch repair protein status along the metastatic course of gastric cancer

2020 ◽  
Vol 76 (5) ◽  
pp. 740-747
Author(s):  
Bastian Dislich ◽  
Nicola Blaser ◽  
Martin D Berger ◽  
Beat Gloor ◽  
Rupert Langer
Keyword(s):  
Gastric Cancer ◽  
Mismatch Repair ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Protein Status ◽  
Repair Protein ◽  
Epstein Barr ◽  
Mismatch Repair Protein

scholarly journals Plasma Epstein-Barr Virus Load as an Early Biomarker and Prognostic Factor of Human Immunodeficiency Virus–related Lymphomas

2018 ◽  
Vol 68 (5) ◽  
pp. 834-843 ◽  
Author(s):  
Josep Muncunill ◽  
Maria-Joao Baptista ◽  
Águeda Hernandez-Rodríguez ◽  
Judith Dalmau ◽  
Olga Garcia ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Prognostic Factor ◽  
Epstein Barr Virus ◽  
Virus Load ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Early Biomarker ◽  
Epstein Barr
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