scholarly journals Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye's Stress Coping Response: Progress, Achievements, and the Future

Gut and Liver ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 153-167 ◽  
Author(s):  
Predrag Sikiric ◽  
Ki-Baik Hahm ◽  
Alenka Boban Blagaic ◽  
Ante Tvrdeic ◽  
Katarina Horvat Pavlov ◽  
...  
Keyword(s):  
Stress Coping ◽  
Coping Response ◽  
Adaptive Cytoprotection ◽  
Bpc 157 ◽  
The Future ◽  
Pentadecapeptide Bpc 157

BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection

2020 ◽  
Vol 26 (25) ◽  
pp. 2971-2981 ◽  
Author(s):  
Jong M. Park ◽  
Ho J. Lee ◽  
Predrag Sikiric ◽  
Ki B. Hahm
Keyword(s):  
Gastric Epithelium ◽  
Epithelial Permeability ◽  
Leaky Gut ◽  
Adaptive Cytoprotection ◽  
Bpc 157 ◽  
Medical Needs ◽  
Pentadecapeptide Bpc 157 ◽  
Inflammatory Drugs ◽  
First Time ◽  
Unmet Medical Needs

The stable gastric pentadecapeptide BPC 157 protects stomach cells, maintains gastric integrity against various noxious agents such as alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs), and exerts cytoprotection/ adaptive cytoprotection/organoprotection in other epithelia, that is, skin, liver, pancreas, heart, and brain. Especially BPC 157 counteracts gastric endothelial injury that precedes and induces damage to the gastric epithelium and generalizes "gastric endothelial protection" to protection of the endothelium of other vessels including thrombosis, prolonged bleeding, and thrombocytopenia. In this background, we put the importance of BPC 157 as a possible way of securing GI safety against NSAIDs-induced gastroenteropathy since still unmet medical needs to mitigate NSAIDs-induced cytotoxicity are urgent. Furthermore, gastrointestinal irritants such as physical or mental stress, NSAIDs administration, surfactants destroyer such as bile acids, alcohol can lead to leaky gut syndrome through increasing epithelial permeability. In this review article, we described the potential rescuing actions of BPC 157 against leaky gut syndrome after NSAIDs administration for the first time.

Revised Roberts Cytoprotection and Adaptive Cytoprotection and Stable Gastric Pentadecapeptide BPC 157. Possible Significance and Implications for Novel Mediator

2010 ◽  
Vol 16 (10) ◽  
pp. 1224-1234 ◽  
Author(s):  
Predrag Sikiric ◽  
Sven Seiwerth ◽  
Luka Brcic ◽  
Marko Sever ◽  
Robert Klicek ◽  
...  
Keyword(s):  
Adaptive Cytoprotection ◽  
Bpc 157 ◽  
Pentadecapeptide Bpc 157

Mo1261 Cyclophosphamide Induced Stomach Lesions in Rats. Aggravation by L-NAME, Counteraction by Stable Gastric Pentadecapeptide BPC 157

2016 ◽  
Vol 150 (4) ◽  
pp. S681-S682
Author(s):  
Kresimir Luetic ◽  
Mario Sucic ◽  
Zeljka Belosic Halle ◽  
Dean Strinic ◽  
Marinko Marusic ◽  
...  
Keyword(s):  
Bpc 157 ◽  
Pentadecapeptide Bpc 157

W1337 Therapy With Gastric Pentadecapeptide BPC 157 (PL14736) and L-NAME in Short Bowel Syndrome and Entero-Enteral Anastomosis Healing in Rats

2010 ◽  
Vol 138 (5) ◽  
pp. S-702
Author(s):  
Marko Sever ◽  
Robert Klicek ◽  
Luka Brcic ◽  
Spomenko Ilic ◽  
Bozo Radic ◽  
...  
Keyword(s):  
Short Bowel Syndrome ◽  
Short Bowel ◽  
Bpc 157 ◽  
Pentadecapeptide Bpc 157 ◽  
Anastomosis Healing

scholarly journals Pentadecapeptide BPC 157 counteracts celecoxib‐induced lesions on gastric mucosa in rats (840.6)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Domagoj Drmic ◽  
Danijela Kolenc ◽  
Sven Seiwerth ◽  
Predrag Sikiric
Keyword(s):  
Gastric Mucosa ◽  
Bpc 157 ◽  
Pentadecapeptide Bpc 157

scholarly journals Stable Pentadecapeptide BPC 157 and Vesicovaginal Fistulas in Rats

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Domagoj Rasic ◽  
Marko Sever ◽  
Anita Zenko Sever ◽  
Katarina Horvat Pavlov ◽  
Marko Baric ◽  
...  
Keyword(s):  
Bpc 157 ◽  
Pentadecapeptide Bpc 157 ◽  
Vesicovaginal Fistulas
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