scholarly journals The Long-Term Effect of Early Anti-Tumor Necrosis Factor on Restoration of Growth in Pediatric Crohn's Disease

Gut and Liver ◽  
2018 ◽  
Vol 12 (3) ◽  
pp. 221-222 ◽  
Author(s):  
Jung Ok Shim ◽  
Yoon Tae Jeen
Keyword(s):  
Crohn’S Disease ◽  
Tumor Necrosis Factor ◽  
Crohn's Disease ◽  
Tumor Necrosis ◽  
Term Effect ◽  
Long Term Effect ◽  
Necrosis Factor

scholarly journals Early treatment with anti‐tumor necrosis factor agents improves long‐term effectiveness in symptomatic stricturing Crohn’s disease

2020 ◽  
Vol 8 (9) ◽  
pp. 1056-1066
Author(s):  
Iago Rodríguez‐Lago ◽  
Javier Hoyo ◽  
Alexandre Pérez‐Girbés ◽  
Alejandro Garrido‐Marín ◽  
María José Casanova ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Tumor Necrosis Factor ◽  
Crohn's Disease ◽  
Early Treatment ◽  
Tumor Necrosis ◽  
Necrosis Factor

scholarly journals Long-term prognosis of Japanese patients with biologic-naïve Crohn’s disease treated with anti-tumor necrosis factor-α antibodies

2019 ◽  
Vol 17 (1) ◽  
pp. 94-106 ◽  
Author(s):  
Rintaro Moroi ◽  
Katsuya Endo ◽  
Katsutoshi Yamamoto ◽  
Takeo Naito ◽  
Motoyuki Onodera ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Tumor Necrosis Factor ◽  
Crohn's Disease ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Japanese Patients ◽  
Long Term Prognosis ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Long‐term outcomes of anti‐tumor necrosis factor therapy and surgery in nonperianal fistulizing Crohn's disease

JGH Open ◽  
2021 ◽  
Author(s):  
Sudheer K Vuyyuru ◽  
Devendra Desai ◽  
Saurabh Kedia ◽  
Pavan Dhoble ◽  
Pabitra Sahu ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Tumor Necrosis Factor ◽  
Crohn's Disease ◽  
Tumor Necrosis ◽  
Long Term Outcomes ◽  
Factor Therapy ◽  
Necrosis Factor

scholarly journals Real world analysis on the efficacy and safety of anti-tumor necrosis factor therapy in patients with stricturing Crohn’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sudheer K. Vuyyuru ◽  
Bhaskar Kante ◽  
Peeyush Kumar ◽  
Pabitra Sahu ◽  
Saurabh Kedia ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Tumor Necrosis Factor ◽  
Crohn's Disease ◽  
Adverse Events ◽  
Tumor Necrosis ◽  
Treatment Success ◽  
Short Term Treatment ◽  
Increased Risk ◽  
Necrosis Factor

AbstractCrohn’s disease (CD) is often complicated by strictures and associated with increased risk for surgery. Inflammatory strictures respond to medical therapy, and anti-tumor necrosis factor (TNF) therapy is often used after the failure of steroids. However, data on efficacy of anti-TNF therapy in stricturing CD is limited. We retrospectively analysed the records of patients with stricturing CD who were treated with anti-TNF therapy and were prospectively followed from January 2005 to July 2020. Treatment success was defined as continuation of anti-TNF without the requirement for steroids or parenteral nutrition, switch to other anti-TNF, endoscopic dilation, surgery and severe adverse events leading to the withdrawal of anti-TNF. Fifty-nine patients were included [50-infliximab, 9-adalimumab; mean age-30.1 ± 15 years; males-69.5%; median disease duration-124 (range 30–396) months; median follow-up duration-42 (range 8–180) months]. Ileum was the most common site of stricture (69.5%), 20.3% of patients had colonic strictures, and 64.4% had multiple strictures. 55.9% of patients were steroid dependent and 37.3% were steroid refractory. The median duration of anti-TNF therapy was 14 (range 2–96) months, and 54.2% (n = 32) patients received concomitant immunomodulators. 88% improved with induction (11.8% primary non-response), secondary loss of response was seen in 52.2%, and the cumulative probability of treatment success at 1, 2 and 5 years was 69%, 51%, and 28% respectively. Anaemia at presentation predicted poor response. Only 30% of patients retained biologics on long-term (lack of response, cost, adverse events). 16.9% had adverse events, the commonest being reactivation of tuberculosis (5.1%). Anti-TNF therapy is associated with good short-term treatment success with modest long-term response in stricturing CD.

scholarly journals Long-Term Prognosis of Japanese Patients with Crohn’s Disease Treated by Switching Anti-Tumor Necrosis Factor-α Antibodies

2019 ◽  
Vol 5 (1) ◽  
pp. 11-19
Author(s):  
Rintaro Moroi ◽  
Hisashi Shiga ◽  
Katsuya Endo ◽  
Katsutoshi Yamamoto ◽  
Masatake Kuroha ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Tumor Necrosis Factor ◽  
Crohn's Disease ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Japanese Patients ◽  
Long Term Prognosis ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn’s disease

2019 ◽  
Vol 25 (14) ◽  
pp. 1764-1774 ◽  
Author(s):  
Ignacio Alfaro ◽  
Maria Carme Masamunt ◽  
Nuria Planell ◽  
Alicia López-García ◽  
Jesús Castro ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Tumor Necrosis Factor ◽  
Crohn's Disease ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Inhibitors ◽  
Necrosis Factor
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