scholarly journals Prevalence and Implications of Bone Marrow Involvement in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Gut and Liver ◽  
2018 ◽  
Vol 12 (3) ◽  
pp. 278-287 ◽  
Author(s):  
Sang Il Choi ◽  
Myeong-Cherl Kook ◽  
Sanghyun Hwang ◽  
Young-Il Kim ◽  
Jong Yeul Lee ◽  
...  
2016 ◽  
Vol 48 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Jae Yong Park ◽  
Sang Gyun Kim ◽  
Joo Sung Kim ◽  
Hyun Chae Jung

2017 ◽  
Vol 152 (5) ◽  
pp. S260
Author(s):  
Sang Il Choi ◽  
Chan Gyoo Kim ◽  
Il Ju Choi ◽  
Hyeon Seok Eom ◽  
Soo-Jeong Cho

2016 ◽  
Vol 83 (5) ◽  
pp. AB460
Author(s):  
Eun Jeong Gong ◽  
Ji Yong Ahn ◽  
Hwoon-Yong Jung ◽  
Kyoungwon Jung ◽  
Charles J. Cho ◽  
...  

2016 ◽  
Vol 51 (8) ◽  
pp. 942-948 ◽  
Author(s):  
Eun Jeong Gong ◽  
Ji Yong Ahn ◽  
Hwoon-Yong Jung ◽  
Kyoungwon Jung ◽  
Charles J. Cho ◽  
...  

Gut and Liver ◽  
2014 ◽  
Vol 8 (6) ◽  
pp. 637-642 ◽  
Author(s):  
Byung-Hoon Min ◽  
Jun Young Park ◽  
Eun Ran Kim ◽  
Yang Won Min ◽  
Jun Haeng Lee ◽  
...  

2006 ◽  
Vol 24 (19) ◽  
pp. 3136-3141 ◽  
Author(s):  
Markus Raderer ◽  
Stefan Wöhrer ◽  
Berthold Streubel ◽  
Marlene Troch ◽  
Karl Turetschek ◽  
...  

Purpose Molecular data and preliminary clinical findings have suggested mucosa-associated lymphoid tissue (MALT) lymphoma as a multifocal disease in a high percentage of patients. We report our findings with an extensive staging routine applied in patients diagnosed with MALT lymphoma at our institution. Patients and Methods A total of 140 consecutive patients (61 with gastric and 79 with extragastric MALT lymphoma) underwent staging according to a standardized protocol. Staging included gastroscopy with multiple biopsies, endosonography of the upper GI tract, computed tomography of thorax and abdomen, lymph node sonography, colonoscopy with multiple biopsies, otorhinolaryngologic assessment, magnetic resonance imaging of salivary and lacrimal glands, and bone marrow biopsy. All lesions suggestive of lymphoma involvement were subjected to biopsy, if accessible, and biopsies were evaluated for MALT lymphoma–specific genetic aberrations by means of reverse transcriptase polymerase chain reaction and/or fluorescent in situ hybridization. Results Fifteen (25%) of 61 patients with gastric MALT lymphoma had multiorgan involvement, with dissemination beyond the GI tract in six patients. By contrast, significantly more patients with extragastric MALT lymphoma had dissemination to another MALT organ (37 of 79 patients, 46%; P = .045). Nine of these 37 patients had dissemination to the stomach. Only three (2%) of 140 patients had bone marrow involvement. Multifocality was significantly associated with t(11;18)(q21;q21) in gastric lymphomas (P = .045) and with trisomy 18 in extragastric lymphomas (P = .011). Conclusion Our findings suggest that MALT lymphoma frequently presents as a multifocal disease. Extragastric MALT lymphomas are significantly more prone to dissemination than gastric MALT lymphomas.


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