scholarly journals Is the Reinitiation of Antiplatelet Agents Safe at 1 Week after Gastric Endoscopic Submucosal Dissection? Assessment of Bleeding Risk Using the Forrest Classification

Gut and Liver ◽  
2017 ◽  
Vol 11 (4) ◽  
pp. 489-496 ◽  
Author(s):  
Jong Yeul Lee ◽  
Chan Gyoo Kim ◽  
Soo-Jeong Cho ◽  
Young-Il Kim ◽  
Il Ju Choi
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Antiplatelet Agents ◽  
Bleeding Risk ◽  
Submucosal Dissection ◽  
Forrest Classification

Aspirin use and bleeding risk after endoscopic submucosal dissection in patients with gastric neoplasms

Endoscopy ◽  
2012 ◽  
Vol 44 (02) ◽  
pp. 114-121 ◽  
Author(s):  
S-J. Cho ◽  
I. Choi ◽  
C. Kim ◽  
J. Lee ◽  
B.-H. Nam ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Bleeding Risk ◽  
Gastric Neoplasms ◽  
Submucosal Dissection

Mo1109 Antithrombotic Agents and Bleeding Risk After Endoscopic Submucosal Dissection in Patients With Gastric Neoplasms: A Meta-Analysis

2014 ◽  
Vol 146 (5) ◽  
pp. S-559
Author(s):  
Hiroki Yuhara ◽  
Jun Nakamura ◽  
Ryoko Nishina ◽  
Yoko Tsukune ◽  
Tetsufumi Uchida ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Meta Analysis ◽  
Bleeding Risk ◽  
Gastric Neoplasms ◽  
Antithrombotic Agents ◽  
Submucosal Dissection

877 MUCOSAL DEFECT CLOSURE BY ENDOSCOPIC HAND-SUTURING MAY REDUCE BLEEDING RISK AFTER GASTRIC ENDOSCOPIC SUBMUCOSAL DISSECTION: A MULTICENTER PILOT STUDY

2020 ◽  
Vol 91 (6) ◽  
pp. AB71-AB72
Author(s):  
Osamu Goto ◽  
Tsuneo Oyama ◽  
Hiroyuki Ono ◽  
Akiko Takahashi ◽  
Mitsuhiro Fujishiro ◽  
...  
Keyword(s):  
Pilot Study ◽  
Endoscopic Submucosal Dissection ◽  
Bleeding Risk ◽  
Defect Closure ◽  
Submucosal Dissection ◽  
Mucosal Defect

Postoperative bleeding risk after gastric endoscopic submucosal dissection during antithrombotic drug therapy

2018 ◽  
Vol 33 (2) ◽  
pp. 453-460 ◽  
Author(s):  
Yoshiyasu Kono ◽  
Yuka Obayashi ◽  
Yuki Baba ◽  
Hiroyuki Sakae ◽  
Tatsuhiro Gotoda ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Endoscopic Submucosal Dissection ◽  
Postoperative Bleeding ◽  
Bleeding Risk ◽  
Antithrombotic Drug ◽  
Submucosal Dissection

scholarly journals Efficacy of vonoprazan for the prevention of bleeding after gastric endoscopic submucosal dissection with continuous use of antiplatelet agents

2020 ◽  
Vol 08 (04) ◽  
pp. E481-E487
Author(s):  
Shunsuke Yoshii ◽  
Takuya Yamada ◽  
Shinjiro Yamaguchi ◽  
Yoshito Hayashi ◽  
Masanori Nakahara ◽  
...  
Keyword(s):  
Adverse Events ◽  
Endoscopic Submucosal Dissection ◽  
Antiplatelet Therapy ◽  
Perioperative Management ◽  
Antiplatelet Agents ◽  
Thromboembolic Risk ◽  
Bleeding Rate ◽  
Submucosal Dissection ◽  
Antithrombotic Medication ◽  
Continuous Use

Abstract Background Post-procedural bleeding, after gastric endoscopic submucosal dissection (ESD) for high risk thromboembolic cases that require continuous antiplatelet therapy, is challenging. Its incidence rate is > 20 % among those using conventional antacids. We evaluated the efficacy of perioperative management with vonoprazan to prevent post-ESD bleeding. Materials and methods This was a multicenter prospective interventional trial conducted at 10 Japanese referral centers. Patients who regularly used antiplatelet agents (aspirin or thienopyridine derivatives, etc.) and who required continuous antithrombotic medication due to high thromboembolic risk were enrolled. They underwent gastric ESD with continuous aspirin therapy. Oral administration of vonoprazan (20 mg daily) was started from the day of ESD and continued for 28 days. The primary end point was the incidence of post-ESD bleeding. The sample size was 50 patients, and vonoprazan was considered to be effective when the upper threshold of the 95 % confidence interval (CI) for post-ESD bleeding did not exceed 20 %. Results Although 50 patients were enrolled, one patient withdrew consent. Therefore, 49 patients were included in the analysis. One patient who used aspirin and clopidogrel experienced bleeding 11 days after ESD. The overall post-ESD bleeding rate was 2.0 % (1/49; 95 %CI 0.4–10.7 %). Thromboembolic events were not observed. One case of ESD-associated adverse events (perforation) and one case of drug-associated adverse events (drug eruption, possibly due to vonoprazan) were observed. Conclusions Vonoprazan may be efficacious for preventing post-ESD bleeding in patients using continuous antiplatelet therapy, warranting further comparative study to definitively test the effectiveness of the drug.

Endoscopic hand-suturing is feasible, safe, and may reduce bleeding risk after gastric endoscopic submucosal dissection: a multicenter pilot study (with video)

2020 ◽  
Vol 91 (5) ◽  
pp. 1195-1202 ◽  
Author(s):  
Osamu Goto ◽  
Tsuneo Oyama ◽  
Hiroyuki Ono ◽  
Akiko Takahashi ◽  
Mitsuhiro Fujishiro ◽  
...  
Keyword(s):  
Pilot Study ◽  
Endoscopic Submucosal Dissection ◽  
Bleeding Risk ◽  
Submucosal Dissection
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