scholarly journals Limited Effect of Rebamipide in Addition to Proton Pump Inhibitor (PPI) in the Treatment of Post-Endoscopic Submucosal Dissection Gastric Ulcers: A Randomized Controlled Trial Comparing PPI Plus Rebamipide Combination Therapy with PPI Monotherapy

Gut and Liver ◽  
2016 ◽  
Vol 10 (6) ◽  
pp. 917-924 ◽  
Author(s):  
Kazuhiko Nakamura ◽  
Eikichi Ihara ◽  
Hirotada Akiho ◽  
Kazuya Akahoshi ◽  
Naohiko Harada ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Proton Pump Inhibitor ◽  
Combination Therapy ◽  
Endoscopic Submucosal Dissection ◽  
Proton Pump ◽  
Controlled Trial ◽  
Gastric Ulcers ◽  
Limited Effect ◽  
Randomized Controlled ◽  
Submucosal Dissection

scholarly journals Effects of Vonoprazan Compared with Esomeprazole on the Healing of Artificial Postendoscopic Submucosal Dissection Ulcers: A Prospective, Multicenter, Two-Arm, Randomized Controlled Trial

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Yasuaki Ishii ◽  
Hiroaki Yamada ◽  
Takeshi Sato ◽  
Soichiro Sue ◽  
Hiroaki Kaneko ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Endoscopic Submucosal Dissection ◽  
Proton Pump ◽  
Ulcer Healing ◽  
Controlled Trial ◽  
Drug Effects ◽  
Upper Endoscopy ◽  
Randomized Controlled ◽  
Submucosal Dissection ◽  
Clinical Benefits

Background. Vonoprazan affords more clinical benefits than proton pump inhibitors (PPIs) during the healing of gastroduodenal ulcers. However, it remains controversial whether vonoprazan is more effective than PPIs when used to heal artificial ulcers arising after endoscopic submucosal dissection (ESD). Aim. This study investigated the effects of vonoprazan compared with esomeprazole on the healing of post-ESD artificial ulcers. Methods. Sixty patients who underwent gastric ESD between May 2015 and May 2017 were randomized to treatment with vonoprazan (V group) or esomeprazole (E group) for 8 weeks. Upper endoscopy was performed at 4 and 8 weeks after ESD, and drug effects were estimated based on the ulcer healing rates and shrinkage rates. Results. Fifty-three patients were analyzed. The respective 4- and 8-week ulcer healing rates did not differ significantly between V and E groups (8.0 versus 11.5%, P=0.669; 88.9 versus 84.6%, P=0.420). Similarly, the respective 4- and 8-week ulcer shrinkage rates did not differ significantly between V and E groups (96.8 versus 97.5%, P=0.656; 100 versus 100%, P=0.257). Conclusion. The healing of artificial ulcers after ESD did not differ using vonoprazan or esomeprazole. Both vonoprazan and esomeprazole were effective when used to promote artificial ulcer healing after ESD.

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