Critical review on biological treatment strategies of dairy wastewater

2019 ◽  
Vol 160 ◽  
pp. 94-109 ◽  
Author(s):  
G. Janet Joshiba ◽  
P. Senthil Kumar ◽  
Carolin C. Femina ◽  
Eunice Jayashree ◽  
R. Racchana ◽  
...  
Rheumatology ◽  
2021 ◽  
Author(s):  
Cécile Gaujoux-Viala ◽  
Christophe Hudry ◽  
Elena Zinovieva ◽  
Hélène Herman-Demars ◽  
René-Marc Flipo

Abstract Objectives The STRATEGE study aimed to describe treatment strategies in current practice in RA bDMARD-naive patients with an inadequate response to MTX therapy, and to compare clinical efficacy of the different therapeutic strategies on disease activity after six months. Methods Main inclusion criteria of this prospective, observational, multicentre study were confirmed RA diagnosis, treatment by MTX monotherapy, and need for therapeutic management modification. Results The 722 patients included had a mean (S.D.) RA duration of 5.3 (6.7) years, a mean DAS28 of 4.0 (±1.1); they were all receiving MTX monotherapy, 68% oral, at a mean dose of 15.0 (4.1) mg/wk. Two major strategies were identified: (i) MTX monotherapy dose and/or route optimization (72%) and (ii) bDMARD initiation ± MTX (16%). MTX dosing was modified for 70% of patients, maintained (dose and route) for 28% of patients, and interrupted for 2%. bDMARDs were started when the MTX mean dose was 17.4 mg/wk, 56% parenterally; MTX was maintained concomitantly for 96% of patients. Six-month follow-up results adjusted by propensity score showed that both options were equally successful in improving disease activity and physical function, with 63% and 68% of good-to-moderate EULAR responses, respectively. Conclusion The STRATEGE study shows the importance of initial MTX treatment optimization before initiation of a biological treatment and emphasizes the importance of treat-to-target strategy.


Chemosphere ◽  
2021 ◽  
pp. 130881
Author(s):  
Asfak Patel ◽  
Ambika Arkatkar ◽  
Srishti Singh ◽  
Alija Rabbani ◽  
Juan David Solorza Medina ◽  
...  

2020 ◽  
Vol 35 ◽  
pp. 101232 ◽  
Author(s):  
Pallvi Bhanot ◽  
S. Mary Celin ◽  
T.R. Sreekrishnan ◽  
Anchita Kalsi ◽  
S.K. Sahai ◽  
...  

2018 ◽  
Vol 39 (1_suppl) ◽  
pp. 9S-15S ◽  
Author(s):  
Malcolm E. Dombrowski ◽  
Youichi Yasui ◽  
Christopher D. Murawski ◽  
Lisa A. Fortier ◽  
Eric Giza ◽  
...  

Background: The evidence supporting best practice guidelines in the field of cartilage repair of the ankle are based on both low quality and low levels of evidence. Therefore, an international consensus group of experts was convened to collaboratively advance toward consensus opinions based on the best available evidence on key topics within cartilage repair of the ankle. The purpose of this article is to report the consensus statements on “Conservative Management and Biological Treatment Strategies” developed at the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. Methods: Seventy-five international experts in cartilage repair of the ankle representing 25 countries and 1 territory were convened and participated in a process based on the Delphi method of achieving consensus. Questions and statements were drafted within 11 working groups focusing on specific topics within cartilage repair of the ankle, after which a comprehensive literature review was performed and the available evidence for each statement was graded. Discussion and debate occurred in cases where statements were not agreed upon in unanimous fashion within the working groups. A final vote was then held, and the strength of consensus was characterized as follows: consensus, 51% to 74%; strong consensus, 75% to 99%; unanimous, 100%. Results: A total of 12 statements on Conservative Management and Biological Treatment Strategies reached consensus during the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. Ten statements reached strong consensus (greater than 75% agreement), and 2 achieved consensus. Conclusions: This international consensus derived from leaders in the field will assist clinicians with conservative management and biological treatment strategies for osteochondral lesions of the talus.


Energies ◽  
2020 ◽  
Vol 13 (15) ◽  
pp. 3769 ◽  
Author(s):  
Radosław Żyłka ◽  
Wojciech Dąbrowski ◽  
Paweł Malinowski ◽  
Beata Karolinczak

The intensification of biological wastewater treatment requires the high usage of electric energy, mainly for aeration processes. Publications on energy consumption have been mostly related to municipal wastewater treatment plants (WWTPs). The aim of the research was to elaborate on models for the estimation of energy consumption during dairy WWTP operation. These models can be used for the optimization of electric energy consumption. The research was conducted in a dairy WWTP, operating with dissolved air flotation (DAF) and an activated sludge system. Energy consumption was measured with the help of three-phase network parameter transducers and a supervisory control and data acquisition (SCADA) system. The obtained models provided accurate predictions of DAF, biological treatment, and the overall WWTP energy consumption using chemical oxygen demand (COD), sewage flow, and air temperature. Using the energy consumption of the biological treatment as an independent variable, as well as air temperature, it is possible to estimate the variability of the total electric energy consumption. During the summer period, an increase in the organic load (expressed as COD) discharged into the biological treatment causes higher electric energy consumption in the whole dairy WWTP. Hence, it is recommended to increase the efficiency of the removal of organic pollutants in the DAF process. An application for the estimation of energy consumption was created.


2019 ◽  
Vol 53 (13) ◽  
pp. 7234-7264 ◽  
Author(s):  
Akashdeep Singh Oberoi ◽  
Yanyan Jia ◽  
Huiqun Zhang ◽  
Samir Kumar Khanal ◽  
Hui Lu

2020 ◽  
pp. 153537022096912
Author(s):  
Demissew Shenegelegn Mern ◽  
Tanja Walsen ◽  
Anja Beierfuß ◽  
Claudius Thomé

Degenerative disc disease (DDD) is a painful, chronic and progressive disease, which is characterized by inflammation, structural and biological deterioration of the intervertebral disc (IVD) tissues. DDD is specified as cell-, age-, and genetic-dependent degenerative process that can be accelerated by environmental factors. It is one of the major causes of chronic back pain and disability affecting millions of people globally. Current treatment options, such as physical rehabilitation, pain management, and surgical intervention, can provide only temporary pain relief. Different animal models have been used to study the process of IVD degeneration and develop therapeutic options that may restore the structure and function of degenerative discs. Several research works have depicted considerable progress in understanding the biological basis of disc degeneration and the therapeutic potentials of cell transplantation, gene therapy, applications of supporting biomaterials and bioactive factors, or a combination thereof. Since animal models play increasingly significant roles in treatment approaches of DDD, we conducted an electronic database search on Medline through June 2020 to identify, compare, and discuss publications regarding biological therapeutic approaches of DDD that based on intradiscal treatment strategies. We provide an up-to-date overview of biological treatment strategies in animal models including mouse, rat, rabbit, porcine, bovine, ovine, caprine, canine, and primate models. Although no animal model could profoundly reproduce the clinical conditions in humans; animal models have played important roles in specifying our knowledge about the pathophysiology of DDD. They are crucial for developing new therapy approaches for clinical applications.


1994 ◽  
Vol 30 (5) ◽  
pp. 25-40 ◽  
Author(s):  
Mogens Henze ◽  
Hallvard Ødegaard

Wastewater management in Central and Eastern Europe is a choice between two basic alternatives. One is to build a limited number of high efficiency treatment plants and the other to build a bigger number of plants with less efficiency. The paper discusses these options, based on technical and economical considerations. The conclusion is that a stepwise development, with chemical precipitation as the first step and biological treatment as the second step, in general is the recommendable solution.


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