scholarly journals The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains Malaysia

2020 ◽  
Vol 35 (6) ◽  
pp. e189-e189
Author(s):  
Marini Ramli ◽  
Zefarina Zulkafli ◽  
Geoffrey Keith Chambers ◽  
Raja Sabrina Amani Raja Zilan ◽  
Hisham Atan Edinur
Keyword(s):  
Blood Donors ◽  
Screening Method ◽  
Serological Testing ◽  
Donor Pool ◽  
Transmitted Infection ◽  
Infection Transmission ◽  
Transfusion Transmitted Infection ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
Donated Blood

Objectives: Blood bank centers routinely screen for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) to ensure the safety of blood supply and thus prevent the dissemination of these viruses via blood transfusion. We sought to evaluate the detection of transfusion-transmitted infection (TTI) markers using standard serological methods and nucleic acid testing (NAT) among blood donors in Hospital Universiti Sains Malaysia. Methods: Donated blood units were assessed for the presence or absence of HBV, HCV, and HIV using two screening method: serology and NAT. Reactive blood samples were then subjected to serological confirmatory and NAT discriminatory assays. Results: A total of 9669 donors were recruited from September 2017 to June 2018. Among these, 36 donors were reactive either for HBV, HCV, or HIV by serological testing and eight by NAT screening. However, only 10 (three for HBV and seven for HCV) donors tested positive using serological testing and five (two for HBV and three for HCV) by NAT discriminatory assays. Note that all five NAT positive donors detected in the NAT discriminatory assays were confirmed to be serologically reactive. Therefore, the prevalence of HBV, HCV, and HIV was 0.03%, 0.1%, and 0.0%, respectively, in our donor pool. Conclusions: Both serological and NAT screening and confirmatory assays should be used routinely to reduce the risk of infection transmission via the transfusion of blood and blood components.

Identification of risk factors in blood donors found to have HIV infection

2000 ◽  
Vol 11 (11) ◽  
pp. 728-730 ◽  
Author(s):  
C M Bates ◽  
P B Carey ◽  
V J Martlew ◽  
A J N Shepherd
Keyword(s):  
Risk Factors ◽  
Blood Donors ◽  
Transmitted Infection ◽  
Infected Blood ◽  
Hiv Rna ◽  
North Wales ◽  
Transfusion Transmitted Infection ◽  
Immunodeficiency Virus ◽  
Donated Blood ◽  
Made In

To ascertain whether current screening procedures for human immunodeficiency virus (HIV) infected blood can be improved, a study of blood donors found by Mersey and North Wales Blood Centre to be HIV positive was made. In total 22 donors were identified, of which 16 were referred to the Department of Genito-Urinary Medicine (GUM) in Liverpool. Most (9/16) should have been excluded from donating because of recognized risk factors. However, in 7 cases no such identifiable factors were found. Although the risk of transfusion transmitted infection is small, there is an argument for testing donated blood for HIV RNA by nucleic acid technology.

scholarly journals Prevalence of Transfusion Transmitted Infection among Blood Donors at Medical University in Bangladesh

2017 ◽  
Vol 6 (1) ◽  
pp. 11-13
Author(s):  
Ferdous Ara ◽  
ABM Mashiul Alam ◽  
Manjuma Rahman ◽  
Asifa Jahan ◽  
Abdullah Yusuf ◽  
...  
Keyword(s):  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Venereal Disease ◽  
Transmitted Infection ◽  
Major Health Problem ◽  
Transfusion Transmitted Infection ◽  
Immunodeficiency Virus ◽  
The Status ◽  
Donated Blood ◽  
Medical University

Background: Blood transfusion is associated with a number of complications. Transfusion transmitted infections (TTI) are one of the major health problem in Bangladesh.Objective: The objective of the present study was to assess the status of transfusion transmitted infections among the apparently healthy donors.Methodology: This study we carried out among 12,294 blood donors from September 2009 to March 2010 at Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. All the samples were screened for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), human immunodeficiency virus (HIV) 1 and 2, venereal disease research laboratory test (VDRL) and malaria to see the prevalence of TTI.Results: Prevalence of HBV, HCV, HIV, and syphilis were 0.009, 0.0004, 0.0001 and 0.0001% respectively. No blood donor tested showed positivity for malarial parasite.Conclusion: Mandatory screening of donated blood and use of sensitive screening test should be done to reduce TTI in Bangladesh.J Shaheed Suhrawardy Med Coll, June 2014, Vol.6(1); 11-13

scholarly journals Seroprevalence of Hepatitis B, Hepatitis C and Human Immunodeficiency Virus Among Multitransfused Thalassaemic Children in Dhaka, Bangladesh

2014 ◽  
Vol 37 (3) ◽  
pp. 146-153 ◽  
Author(s):  
AKM Rezaul Karim ◽  
Afiqul Islam ◽  
Choudhury Yakub Jamal ◽  
Abdul Matin ◽  
Md Monir Hossain ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Transmitted Infection ◽  
Transfusion Transmitted Infection ◽  
B Virus ◽  
Immunodeficiency Virus

Background: Thalassaemia is a congenital hemolytic disease caused by defective globin chain synthesis of haemoglobin and largely treated by repeated blood transfusions. Transfusion-transmitted infections still make a great challenge in the management of patients with thalassaemia major. The most important worldwide transfusion transmitted infections (TTI) are hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Despite concern about a possible increase in the incidence of these infections there are no recent data about the prevalence of HBV, HCV and HIV from Bangladesh. Objectives: To evaluate the prevalence of hepatitis B, hepatitis C and human immunodeficiency virus in multi-transfused thalassaemia patients (MTP), to identify the possible risk factors and to evaluate the effect of compulsory screening of blood to prevent these infections. Methodology: This cross-sectional study was conducted during 2011 to 2012 on 100 consecutive multi-transfused thalassaemic patients who were interviewed using a structured questionnaire and tested for serological markers of hepatitis B virus (HBsAg), hepatitis C virus (Anti-HCV) and human immunodeficiency virus (Anti-HIV 1+2). Results: The overall prevalence of HCV, HBV, HIV and co-infection among (MTP) were 31%, 3%, 0% and 1%, respectively. Children who developed infection had a higher incidence of receiving transfusion from professional donors or unknown donors than the non-infected ones. Infected children had a higher frequency of receiving transfusions without screening and receiving more number of transfusions than their counterpart. Other non-transfusion related (NTR) risk factors such as surgical operation, dental procedures, needle stick injury were significantly higher in patients who acquired transfusion transmitted infections (TTI). Conclusions: HCV infection was the most prevalent transfusion transmitted infection (TTI) among multi-transfused thalassaemia patients (MTP) and remains a major health problem for these patients. Children who received transfusion from professional donors and received unscreened blood had more chance of getting infection with transfusion transmitted infection. DOI: http://dx.doi.org/10.3329/bjch.v37i3.18618 Bangladesh J Child Health 2013; Vol.37(3): 146-153

scholarly journals The incidence and spectrum of transfusion transmitted infections among the blood donors

2018 ◽  
Vol 6 (3) ◽  
pp. 904
Author(s):  
Smita Mahapatra ◽  
Gopal Krushna Ray ◽  
Rashmita Panigrahi ◽  
Pankaj Parida
Keyword(s):  
Blood Donors ◽  
Preventive Measures ◽  
Test Methods ◽  
Blood Components ◽  
Major Health ◽  
Highly Sensitive ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
Safe Blood ◽  
Donated Blood

Background: Transfusion Transmitted Infections (TTIs), particularly through the viruses lead to the major health problems and challenges faced by the transfusion services for the supply of safe blood and blood components. The objective of the study is to assess the incidence and spectrum of five TTIs like Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV), Malaria Parasites (MP) and Syphilis among both voluntary and replacement blood donors in a span of seven years.Methods: Total 1, 38,994 voluntary and replacement blood donors were screened and 1,012 (0.73%) cases were seropositive of which 631 cases (0.64%) were found in voluntary donors and 381 cases (0.94%) were seen in replacement donors.Results: Majority of the donors were reactive for HBV infection (0.5%) followed by HCV (0.17%), HIV (0.052%), Syphilis (0.001%) and malaria (0.0005%). There was increase in the trend of seroprevalence of TTIs from 0.35% (2010) to 1.43% (2016) over the period which is a matter of consideration.Conclusions: It is therefore very important to continue preventive measures to combat this problem along with screening of donated blood units with highly sensitive test methods and post donation counselling of the seropositive donors for the prevention of further transmission risks.

scholarly journals Frequency of Hepatitis B, C and HIV Infections among Transfusion-Dependent Beta Thalassemia Patients in Dhaka

2021 ◽  
Vol 13 (1) ◽  
pp. 89-95
Author(s):  
Golam Sarower Bhuyan ◽  
Aftab Uz Zaman Noor ◽  
Rosy Sultana ◽  
Farjana Akther Noor ◽  
Nusrat Sultana ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Infections ◽  
Rapid Test ◽  
Hiv Infections ◽  
Beta Thalassemia ◽  
Nucleic Acid Testing ◽  
Serological Testing ◽  
Elisa Method ◽  
B Virus ◽  
Immunodeficiency Virus

Transfusion transmitted infections have remained a major deterrent to public health, particularly among the patients with transfusion-dependent Beta thalassemia in developing countries. Although proper donor selection through adoption of WHO-advised infection panel has lowered the rate of infections, the multi-transfused patients are not free of risk. In this study, we screened 148 transfusion-dependent Beta thalassemia patients to determine the frequency of Hepatitis C Virus (HCV), Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV) using the ELISA method. Among them, infected cases with HCV, HBV and HIV were 13.51%, 3.37% and 0%, respectively. Moreover, 2% of the patients were found to be co-infected with both HBV and HCV. The percentage of infections in the patients with frequent transfusion interval (≤30 days) was significantly higher (p < 0.0005) than that in the patients with less frequent transfusion intervals (>30 days). Immunochromatography (ICT)-based rapid test kits are usually used to screen and confirm these infections in the blood of the patients. However, ICT-based tests are not sensitive enough to detect the infections. So, a combination of both Nucleic Acid testing (NAT) and serological testing are suggested to significantly reduce the risk of viral infections during blood transfusion.

scholarly journals Improved molecular laboratory productivity by consolidation of testing on the new random-access analyzer Alinity m

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Martin Obermeier ◽  
Monia Pacenti ◽  
Robert Ehret ◽  
Francesco Onelia ◽  
Rory Gunson ◽  
...  
Keyword(s):  
Trichomonas Vaginalis ◽  
Random Access ◽  
Mycoplasma Genitalium ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
International Multicenter Study ◽  
Laboratory Productivity ◽  
Laboratory Workflow

AbstractObjectivesAutomated molecular analyzers have accelerated diagnosis, allowing earlier intervention and better patient follow-up. A recently developed completely automated molecular analyzer, Alinity™ m (Abbott), offers consolidated, continuous, and random-access testing that may improve molecular laboratory workflow.MethodsAn international, multicenter study compared laboratory workflow metrics across various routine analyzers and Alinity m utilizing assays for human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), hepatitis B virus (HBV), high-risk human papillomavirus (HR HPV), and sexually transmitted infection (STI) (Chlamydia trachomatis [CT]/Neisseria gonorrhoeae [NG]/Trichomonas vaginalis [TV]/Mycoplasma genitalium [MG]). Three turnaround times (TATs) were assessed: total TAT (sample arrival to result), sample onboard TAT (sample loading and test starting to result), and processing TAT (sample aspiration to result).ResultsTotal TAT was reduced from days with routine analyzers to hours with Alinity m, independent of requested assays. Sample onboard TATs for standard workflow using routine analyzers ranged from 7 to 32.5 h compared to 2.75–6 h for Alinity m. The mean sample onboard TAT for STAT samples on Alinity m was 2.36 h (±0.19 h). Processing TATs for Alinity m were independent of the combination of assays, with 100% of results reported within 117 min.ConclusionsThe consolidated, continuous, random-access workflow of Alinity m reduces TATs across various assays and is expected to improve both laboratory operational efficiency and patient care.

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