scholarly journals Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jka and Anti-E: A Case Report

2020 ◽  
Vol 35 (6) ◽  
pp. e206-e206
Author(s):  
Salfarina Iberahim ◽  
Maryam Jameelah Aizuddin ◽  
Nurulhuda Abd Kadir ◽  
Nabilah Rameli ◽  
Sumaiyah Adzahar ◽  
...  

The majority of hemolytic disease of the fetus and newborn (HDFN) reported in the literature is due to ABO and rhesus incompatibility. However, there are also other minor blood groups that have been identified as a cause of HDFN, although the occurrence is much rarer. The antibody screening program for D negative mother and the anti-D immunoglobulin treatment showed a significant reduction of the occurrence of HDFN secondary to anti-D. In a developed country, the screening for red blood cell antibody in the pregnant mother other than anti-D reduced the possibility of HDFN occurrence hence reduced the fetal morbidity and subsequently increased the fetal well being during pregnancy and after the postnatal period. In this case report, we discuss HDFN in a primigravida patient secondary to multiple alloantibodies (anti-Jka and anti-E). The baby developed jaundice with bilirubin levels approaching the exchange transfusion level. However, with extensive phototherapy and immunoglobulin treatment, the child did not require exchange transfusion. We also included the importance of the routine antenatal antibody screening program. This practice will help the transfusion center to find the antigen negative blood in a timely manner and reduce the morbidities and mortalities of HDFN among the newborns.

Author(s):  
Nasenien Nourkami-Tutdibi ◽  
Martina Geipel ◽  
Gabriele Meyberg-Solomayer ◽  
Zoltan Takacs ◽  
Sascha Meyer

SummarySignificant progress in prenatal care has decreased the incidence of rhesus incompatibility, which may result in hemolytic disease of the fetus and newborn (HDFN). This case report describes an unusual presentation of HDFN in a preterm infant delivered by caesarean section with isolated massive abdominal fluid collection as the leading clinical sign in addition to severe anemia. The immediate drainage of ascites provided transient clinical stabilization with improved pulmonary function in the delivery suite. After admission to the neonatal intensive care unit (NICU), HDFN treatment was initiated. This case report shows the importance of adequately trained staff including neonatologists, pediatricians and NICU nurses in the delivery suite to provide neonatal intensive care for HDFN.


2021 ◽  
Vol 34 (03) ◽  
pp. 227-234
Author(s):  
Dhiraj Debnath ◽  
Abhiram Banerjee ◽  
Md Mostafijur Rahaman ◽  
Gurudev Choubey

Abstract Introduction Onycholysis is a chronic nail disorder characterised by the progressive separation of the nail plate from the underlying nail bed. Apart from causing pain and discomfort, it affects the quality of life of an individual due to its visualised cosmetic appearance. Case Summary A 45-year-old female presented with complete loss of nail plate of the left middle finger for 1 month. At the first visit, homoeopathic medicine Tuberculinum bovinum was prescribed and the patient was followed up periodically for 4 months. A series of photographs captured at the first visit and in subsequent visits objectively document the gradual regrowth of her nail plate. Various aspects of her subjective improvement were documented by three validated outcome measurement scales. The patient herself assessed that, after 4 months of follow-up, she is ‘back to normal’ for her main complaint as well as for the overall well-being, which is documented as a +4 score in ‘Outcome in Relation to Impact on Daily Living’ (ORIDL) scale. The Dermatology Life Quality Index (DLQI) score was reduced from 20 at the first visit to 1 after 4 months of treatment. Modified Naranjo Criteria for Homeopathy (MONARCH) score recorded at the final visit (+8 in ‘-6 to +13’ scale) is suggestive of a high likelihood that the improvement in the patient can be attributed to the homoeopathic treatment provided. Conclusion This clinical case report is presented here to critically document the effect of individualised homoeopathic treatment in onycholysis within a plausible timeframe.


PEDIATRICS ◽  
1957 ◽  
Vol 20 (4) ◽  
pp. 675-675

Two well-known authorities on hemolytic disease undertake in this paper to determine the causes for what they consider to be an excessive mortality from this disease in England and Wales at the present time. They state that with correct use of exchange transfusion a mortality of not more than 5% of infants with hemolytic disease born alive should be expected. The authors express the opinion that the deaths at present are at least three times as numerous as should be expected with modern treatment. Analysis of the reported deaths seem to indicate two principal causes for this: (1) failure to anticipate the disease before birth or to recognize the disease early after birth, and (2) either failure to undertake an exchange transfusion or to employ satisfactory technique in the exchange transfusion, particularly to give an adequate exchange. They point out that the best results are to be expected in hospitals where a large number of cases are treated and considerable experience is acquired. In hospitals where the number of cases seen is small it is difficult for the staff to gain the necessary experience and familiarity with the technique of exchange transfusion and the general principles of diagnosis and management. A full discussion of the essential points in prediction and diagnosis of the disorder and of the indications for exchange transfusion, with emphasis on the volumes of blood to be exchanged, are given.


2019 ◽  
Vol 30 (3) ◽  
pp. 241-245
Author(s):  
Han-Sol Kim ◽  
Chae-Ku Jo ◽  
Sin-Young Kim ◽  
Kyeong-Hee Kim ◽  
Myo-Jing Kim

2007 ◽  
Vol 1 (2) ◽  
pp. 56 ◽  
Author(s):  
DC Sharma ◽  
Sunita Rai ◽  
Aakash Mehra ◽  
MM Kaur ◽  
Satya Sao ◽  
...  

2012 ◽  
Vol 6 (2) ◽  
pp. 103-127 ◽  
Author(s):  
Helen Russell

This article is based on a qualitative study of later life computer learners and their learning experiences in Sydney, Australia. Participants who undertook lessons from peer tutors in non-formal learning environments were aged between 63 and 86. Sixteen later life learners were interviewed individually by using hermeneutic phenomenological methodology. The use of semi-structured interviews provided opportunities for participants to elaborate and reflect on their learning and lived experiences. The interviews took place over a period of seven years, from 2003 to 2010. The main aim of the study was to understand and interpret the lived experiences of information and communication technology (ICT) learning in later life. Interpretations from the study suggested that learning and using a computer contributed to a sense of well-being, furthered an understanding of the lifeworld and provided participants with a heightened sense of belonging. In this article, well-being is discussed in the context of ageing and learning in a modern developed country. The ontological and existential themes of being, becoming and belonging are explored and used as a framework to interpret the findings from the study.


2020 ◽  
Vol 3 (2) ◽  
pp. 120-124
Author(s):  
P Manandhar ◽  
S R.B. Mathema

Loss of an eye or any body part has an intimidating and crippling effect on the psychosocial well-being of the patient. Although the artificial prosthesis cannot restore the function, it can highly improve the patient’s esthetics and help them regain their psychological confidence. Literature has advocated various rehabilitation modalities including empirical use of stock shells, modifying stock eyes, custom-made ocular prostheses, ocular implants, etc. A custom-made ocular prosthesis, among all the techniques, shows improved adaptation to tissue bed, distributes uniform pressure, provides a more esthetic and precise result, and is relatively cost-effective. This case report explores a relatively comprehensive method of custom ocular prosthesis fabrication for an ocular defect with a satisfactory outcome. 


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