scholarly journals Evaluating the Relationship between Body Size and Body Shape with the Risk of Breast Cancer

2013 ◽  
Vol 28 (6) ◽  
pp. 389-394 ◽  
Author(s):  
Samira Ebrahimzadeh Zagami ◽  
Nahid Golmakani ◽  
Fatemeh Homaei Shandiz ◽  
Azadeh Saki
Keyword(s):  
Breast Cancer ◽  
Body Size ◽  
Body Shape ◽  
The Relationship

scholarly journals Body shape throughout life and correlations with IGFs and GH

2007 ◽  
Vol 14 (3) ◽  
pp. 721-732 ◽  
Author(s):  
Eva S Schernhammer ◽  
Shelley S Tworoger ◽  
A Heather Eliassen ◽  
Stacey A Missmer ◽  
Jeff M Holly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Size ◽  
Birth Weight ◽  
Waist Circumference ◽  
Body Shape ◽  
Premenopausal Women ◽  
Premenopausal Breast Cancer ◽  
Igf I ◽  
Size At Age ◽  
Igfbp 3

Both insulin-like growth factors (IGF) and body size have been linked to premenopausal breast cancer risk. However, observational studies of IGF have not been consistent, and they suggest that perhaps earlier levels of IGF might be more strongly related to breast cancer than those measured at mid-age. We therefore sought to explore associations between several measures of body size throughout life and IGF levels in premenopausal women. We examined cross-sectional associations of birth weight, body shape (or somatotype) at ages 5 and 10, body mass index (BMI) at age 18 and adulthood, bra cup size at age 20, adult waist circumference and waist-to-hip ratio (WHR), and attained height with plasma levels of IGF-I, IGF binding protein 3 (IGFBP-3), IGFBP-1, and GH. Participants were 592 healthy premenopausal women aged 34–52 from the Nurses’ Health Study II. Using multiple linear regression, we computed least-square mean hormone levels across the categories of early life anthropometric factors. We observed consistent and strong inverse associations between body shape at various stages in life and IGF levels. Somatotype at ages 5 and 10 was inversely associated with IGF-I (P for difference, < 0.01) and positively with IGFBP-3 measured later in adulthood. Further, comparing women with a BMI ≥ 25 kg/m2 at age 18 vs < 19 kg/m2, similar associations were observed for IGF-I (P for trend, 0.005) and IGFBP-3 (P for trend, 0.01), which were even stronger for BMI at blood collection (BMI< 20 versus BMI ≥ 30, mean IGF-I 254 ng/ml, 95% CI, 239–271 vs 208 ng/ml, 95% CI, 195–222). Both waist circumference and WHR were strongly and inversely related to IGFBP-1 levels (top versus bottom quartile of waist circumference: 14.5 vs 40.0 ng/ml, P for trend 0.0005; WHR: 18.3 vs 39.4 ng/ml, P for trend 0.002), with similar results for bra cup size at age 20 although they did not reach statistical significance. There was no association between height and IGF or GH levels. Birth weight, on the other hand, was weakly positively associated with both IGF-I and IGFBP-1 levels, and inversely with GH. Our results suggest that childhood and adult body size may affect premenopausal breast cancer risk differently than birth weight, through associations with IGF and GH levels.

The relationship between size-free body shape and choice of retreat for Western Australian Ctenophorus (Agamidae) dragon lizards

2005 ◽  
Vol 26 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Graham Thompson ◽  
Philip Withers
Keyword(s):  
Principal Component Analysis ◽  
Body Size ◽  
Body Shape ◽  
Principal Component ◽  
Species Group ◽  
Ecological Groups ◽  
Hind Limbs ◽  
Free Body ◽  
The Relationship ◽  
Western Australian

AbstractWe examined the relationship between body shape and choice of retreat for males of 17 species of Western Australian Ctenophorus dragon lizards, accounting for body size by using Somers' (1986, 1989) size-free principal component analysis. Ctenophorus species group strongly in size-free morphometric space (shape) based on the nature of their natural retreat (i.e. burrows, no burrows and rocks). Those species that dig their own burrow as a retreat have short tails and hind limbs, whereas that those do not generally retreat to a burrow have longer lower hind limbs and hind feet. Three of the four species that retreat to crevices or under rocks have a dorso-ventrally flattened head and body, and relatively long upper fore-limbs. The fourth rock-retreat species (C. caudicinctus) does not have a dorso-ventrally flattened head and body; its body shape is intermediate between those species in the three ecological groups.

scholarly journals The relationship between body shape, body size and locomotor mode in extant lepidosaurs

2020 ◽  
Vol 311 (3) ◽  
pp. 183-193
Author(s):  
L. R. Grinham ◽  
D. B. Norman
Keyword(s):  
Body Size ◽  
Body Shape ◽  
The Relationship

scholarly journals Body Size in Relation to Oxygen Consumption and Pleopod Beat in Ligia Oceanica L

1951 ◽  
Vol 28 (4) ◽  
pp. 492-507 ◽  
Author(s):  
C. ELLENBY
Keyword(s):  
Body Weight ◽  
Oxygen Consumption ◽  
Body Size ◽  
Body Length ◽  
Body Shape ◽  
Size Range ◽  
Total Oxygen ◽  
Rate Of Oxygen Consumption ◽  
Relationship Of ◽  
The Relationship

1. Male Ligia oceanica were used in an investigation of the relationship of body size to rate of oxygen consumption and pleopod beat. 2. Animals varied in weight from 0.04 to 1.03 g. and from 0.95 to 3.1 cm. in length. 3. Body shape does not change significantly over the size range, for length and breadth both increase at the same rate, and pleopod dimensions bear a constant relation to body length. 4. Specific gravity also is constant, for the relation of body weight to the cube of body length shows no trend with increasing size. 5. Oxygen consumption per gram decreases with increasing size and is proportional to the -0.274 Power of body weight. Total oxygen consumption is therefore proportional to the 0.726 power of body weight; but this value does not differ significantly from two-thirds. 6. As shape is constant, surface area is proportional to the square of a linear dimension. It is shown that oxygen consumption per unit of length2 is constant over the size range. Although body length was measured far less accurately than body weight it is shown that it assesses ‘body size’ more accurately. 7. Rate of pleopod beat was measured at 15 and 25°C.; it decreases with the size of the animal. At 15°C. time per beat varies as the 0.66 power of body length, and at 25°C. as the 0.59 power; neither of these values differs significantly from 0.5. Despite the fact that pleopod movement is heavily damped, the rate therefore varies like that of a pendulum. 9. The workof Fox (1936-9) and Fox et al. (1937a)on the rate of oxygen consumption of animals from cold and warmer seas and from different habitats is considered. It is suggested that many of their comparisons are invalidated by differences in body size of the animals concerned, and that, in relation to environment, no basis, theoretical or experimental, has been established for a distinction between ‘nonlocomotory’ and ‘activity’ metabolism.

CASC15：A tumor-associated long non-coding RNA

2020 ◽  
Vol 26 ◽  
Author(s):  
Bei Wang ◽  
Wen Xu ◽  
Yuxuan Cai ◽  
Chong Guo ◽  
Gang Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Therapeutic Target ◽  
Cancer Colorectal ◽  
Tumor Development ◽  
Pathophysiological Mechanism ◽  
Biological Processes ◽  
Non Coding Rna ◽  
Cancer Côlon ◽  
The Relationship ◽  
Long Non Coding Rna

Background: CASC15, one of long non-coding RNA, is involved in the regulation of many tumor biological processes, and is expected to become a new biological therapeutic target. This paper aims to elucidate the pathophysiological function of CASC15 in various tumors. Methods: The relationship between CASC15 and tumors was analyzed by searching references, and summarizes the specific pathophysiological mechanism of CASC15. Results: LncRNA CASC15 is closely related to tumor development, and has been shown to be abnormally high expressed in all kinds of tumors, including breast cancer, cervical cancer, lung cancer, hepatocellular carcinoma, gastric cancer, bladder cancer, colon cancer, colorectal cancer, cardiac hypertrophy, intrahepatic cholangiocarcinoma, leukemia, melanoma, tongue squamous cell carcinoma, nasopharyngeal carcinoma. However, CASC15 has been found to be downexpressed abnormally in ovarian cancer, glioma and neuroblastoma. Besides, it is identified that CASC15 can affect the proliferation, invasion and apoptosis of tumors. Conclusion: LncRNA CASC15 has the potential to become a new therapeutic target or marker for a variety of tumors.

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