scholarly journals Role of Human Leukocyte Antigens and T Lymphocytes in the Immune Response

1993 ◽  
Vol 2 (2) ◽  
pp. 173-191 ◽  
Author(s):  
Hidetoshi Inoko ◽  
Nobuhisa Mizuki
Keyword(s):  
Immune Response ◽  
T Lymphocytes ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Leukocyte Antigens

scholarly journals Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient

2021 ◽  
Vol 10 (16) ◽  
pp. 3656
Author(s):  
Danae Olaso ◽  
Miriam Manook ◽  
Dimitrios Moris ◽  
Stuart Knechtle ◽  
Jean Kwun
Keyword(s):  
Immune Response ◽  
Transplant Recipient ◽  
Kidney Transplant Recipient ◽  
Human Leukocyte ◽  
Immunosuppressive Regimen ◽  
Human Leukocyte Antigens ◽  
Donor Pool ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection ◽  
Leukocyte Antigens

Patients with previous sensitization events against anti-human leukocyte antigens (HLA) often have circulating anti-HLA antibodies. Following organ transplantation, sensitized patients have higher rates of antibody-mediated rejection (AMR) compared to those who are non-sensitized. More stringent donor matching is required for these patients, which results in a reduced donor pool and increased time on the waitlist. Current approaches for sensitized patients focus on reducing preformed antibodies that preclude transplantation; however, this type of desensitization does not modulate the primed immune response in sensitized patients. Thus, an optimized maintenance immunosuppressive regimen is necessary for highly sensitized patients, which may be distinct from non-sensitized patients. In this review, we will discuss the currently available therapeutic options for induction, maintenance, and adjuvant immunosuppression for sensitized patients.

scholarly journals Physiology and Pathology of Drug Hypersensitivity: Role of Human Leukocyte Antigens

2017 ◽  
Author(s):  
Gwendolin Simper ◽  
Alexander A. Celik ◽  
Heike Kunze-Schumacher ◽  
Rainer Blasczyk ◽  
Christina Bade-Döding
Keyword(s):  
Drug Hypersensitivity ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Leukocyte Antigens

scholarly journals Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases

2018 ◽  
Vol 5 (1) ◽  
pp. 5-20 ◽  
Author(s):  
Gergely Bodis ◽  
Victoria Toth ◽  
Andreas Schwarting
Keyword(s):  
Autoimmune Diseases ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Leukocyte Antigens

Human leukocyte antigens influence the immune response to a pre-S/S hepatitis B vaccine

Vaccine ◽  
1999 ◽  
Vol 17 (4) ◽  
pp. 330-339 ◽  
Author(s):  
A.B McDermott ◽  
S.B.A Cohen ◽  
J.N Zuckerman ◽  
J.A Madrigal
Keyword(s):  
Immune Response ◽  
Hepatitis B ◽  
Human Leukocyte ◽  
Hepatitis B Vaccine ◽  
Human Leukocyte Antigens ◽  
Leukocyte Antigens

Role of immunoglobulin (Ig)-G and IgM antibodies against donor human leukocyte antigens in organ transplant recipients

2009 ◽  
Vol 70 (8) ◽  
pp. 600-604 ◽  
Author(s):  
Peter Stastny ◽  
Steves Ring ◽  
Christopher Lu ◽  
Juan Arenas ◽  
Mei Han ◽  
...  
Keyword(s):  
Organ Transplant ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Igm Antibodies ◽  
Leukocyte Antigens ◽  
Ig G
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