scholarly journals Role of Human Leukocyte Antigens and T Lymphocytes in the Immune Response

1993 ◽  
Vol 2 (2) ◽  
pp. 173-191 ◽  
Author(s):  
Hidetoshi Inoko ◽  
Nobuhisa Mizuki
2021 ◽  
Vol 10 (16) ◽  
pp. 3656
Author(s):  
Danae Olaso ◽  
Miriam Manook ◽  
Dimitrios Moris ◽  
Stuart Knechtle ◽  
Jean Kwun

Patients with previous sensitization events against anti-human leukocyte antigens (HLA) often have circulating anti-HLA antibodies. Following organ transplantation, sensitized patients have higher rates of antibody-mediated rejection (AMR) compared to those who are non-sensitized. More stringent donor matching is required for these patients, which results in a reduced donor pool and increased time on the waitlist. Current approaches for sensitized patients focus on reducing preformed antibodies that preclude transplantation; however, this type of desensitization does not modulate the primed immune response in sensitized patients. Thus, an optimized maintenance immunosuppressive regimen is necessary for highly sensitized patients, which may be distinct from non-sensitized patients. In this review, we will discuss the currently available therapeutic options for induction, maintenance, and adjuvant immunosuppression for sensitized patients.


Author(s):  
Gwendolin Simper ◽  
Alexander A. Celik ◽  
Heike Kunze-Schumacher ◽  
Rainer Blasczyk ◽  
Christina Bade-Döding

2018 ◽  
Vol 5 (1) ◽  
pp. 5-20 ◽  
Author(s):  
Gergely Bodis ◽  
Victoria Toth ◽  
Andreas Schwarting

Vaccine ◽  
1999 ◽  
Vol 17 (4) ◽  
pp. 330-339 ◽  
Author(s):  
A.B McDermott ◽  
S.B.A Cohen ◽  
J.N Zuckerman ◽  
J.A Madrigal

2009 ◽  
Vol 70 (8) ◽  
pp. 600-604 ◽  
Author(s):  
Peter Stastny ◽  
Steves Ring ◽  
Christopher Lu ◽  
Juan Arenas ◽  
Mei Han ◽  
...  

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