scholarly journals Clinical Impact of Poorly Differentiated Cluster at the Invasive Front in Colorectal Cancer Invading beyond the Muscle Layer

2020 ◽  
Vol 28 (2) ◽  
pp. 107-110
Author(s):  
Kazuhiko Yoshimatsu ◽  
Masaya Satake ◽  
Teppei Kono ◽  
Shinichi Asaka ◽  
Megumi Sano ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Muscle Layer ◽  
Clinical Impact ◽  
Invasive Front ◽  
Poorly Differentiated

Poorly Differentiated Clusters: Clinical Impact in Colorectal Cancer

2017 ◽  
Vol 16 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Valeria Barresi ◽  
Luca Reggiani Bonetti ◽  
Antonio Ieni ◽  
Rosario Alberto Caruso ◽  
Giovanni Tuccari
Keyword(s):  
Colorectal Cancer ◽  
Clinical Impact ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

COMPARATIVE EVALUATION OF MULTIPARAMETRIC ENDORECTAL ULTRASOUND AND ENHANCED IMAGING COLONOSCOPY IN THE DIAGNOSIS OF EARLY COLORECTAL CANCER

2020 ◽  
Vol 19 (3) ◽  
pp. 49-64
Author(s):  
E. M. Bogdanova ◽  
Yu. L. Trubacheva ◽  
O. M. Yugai ◽  
S. V. Chernyshov ◽  
E. G. Rybakov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Statistical Significance ◽  
Muscle Layer ◽  
Endorectal Ultrasound ◽  
Diagnostic Methods ◽  
Early Colorectal Cancer ◽  
Morphological Examination ◽  
Optical Magnification ◽  
The Difference ◽  
Enhanced Imaging

AIM: to compare multiparametric endorectal ultrasound (ERUS) and enhanced imaging colonoscopy in the diagnosis of early colorectal cancer.PATIENTS AND METHODS: the study included 78 patients with epithelial rectal tumor. All the patients underwent multiparametric ERUS and colonoscopy with examination by narrow beam imaging (NBI) at optical magnification. All the patients were operated.RESULTS: a morphological examination removed specimens revealed adenomas in 48 cases, in 19 specimens – adenocarcinomas in situ and T1, and in 11 specimens – adenocarcinomas with invasion of the muscle layer or deeper. When calculating the accuracy indicators of diagnostic methods for groups of patients with adenoma, Tis-T1 adenocarcinoma, and T2-T3 adenocarcinoma, the difference in the sensitivity and specificity of the methods in none of the presented groups did not reach the level of statistical significance (p>0.05).ROC analysis showed that ultrasound has a prognostic value comparable to colonoscopy. The area difference was 0.013 (p=0.85).CONCLUSION: endoscopy and ultrasound have similar value in the diagnosis of malignant transformation of rectal adenomas.

scholarly journals Deficient HER3 expression in poorly-differentiated colorectal cancer cells enhances gefitinib sensitivity

2014 ◽  
Vol 45 (4) ◽  
pp. 1583-1593 ◽  
Author(s):  
SUSUMU NAKATA ◽  
HARUNARI TANAKA ◽  
YUICHI ITO ◽  
MASAYASU HARA ◽  
MITSUGU FUJITA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Colorectal Cancer Cells ◽  
Her3 Expression ◽  
Poorly Differentiated

scholarly journals Separation of Low- Versus High-grade Crohn’s Disease-associated Small Bowel Carcinomas is Improved by Invasive Front Prognostic Marker Analysis

2019 ◽  
Vol 14 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Giovanni Arpa ◽  
Federica Grillo ◽  
Paolo Giuffrida ◽  
Gabriella Nesi ◽  
Catherine Klersy ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Stage I ◽  
Low Grade ◽  
Invasive Front ◽  
Poorly Differentiated Clusters ◽  
Small Bowel Carcinoma ◽  
Poorly Differentiated ◽  
Tumour Budding

Abstract Background and Aims Crohn’s disease-associated small bowel carcinoma is a rare event, usually reported to have a severe prognosis. However, in previous investigations we have found a minority of cases displaying a relatively favourable behaviour, thus outlining the need to improve the histopathological prediction of Crohn’s disease-associated small bowel carcinoma prognosis. Methods As in recent studies on colorectal cancer, a substantial improvement in prognostic evaluations has been provided by the histological analysis of the tumour invasive front; we therefore systematically analysed the tumour budding and poorly differentiated clusters in the invasive front of 47 Crohn’s disease-associated small bowel carcinomas collected through the Small Bowel Cancer Italian Consortium. Results Both tumour budding and poorly differentiated cluster analyses proved highly effective in prognostic evaluation of Crohn’s disease-associated small bowel carcinomas. In addition, they retained prognostic value when combined with two other parameters, i.e. glandular histology and stage I/II, both known to predict a relatively favourable small bowel carcinoma behaviour. In particular, association of tumour budding and poorly differentiated clusters in a combined invasive front score allowed identification of a minor subset of cancers [12/47, 25%] characterised by combined invasive front low grade coupled with a glandular histology and a low stage [I or II] and showing no cancer-related death during a median follow-up of 73.5 months. Conclusions The improved distinction of lower- from higher-grade Crohn’s disease-associated small bowel carcinomas provided by invasive front analysis should be of potential help in choosing appropriate therapy for these rare and frequently ominous neoplasms.

scholarly journals N-glycomic signature of stage II colorectal cancer and its association with the tumor microenvironment

2020 ◽  
pp. mcp.RA120.002215
Author(s):  
Fanny Boyaval ◽  
René Van Zeijl ◽  
Hans Dalebout ◽  
Stephanie Holst ◽  
Gabi W. van Pelt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mass Spectrometry Imaging ◽  
Stage Ii ◽  
Cell Populations ◽  
Invasive Front ◽  
Tissue Samples ◽  
Sample Group ◽  
Patients At Risk ◽  
Stage Ii Colorectal Cancer ◽  
High Mannose

The choice for adjuvant chemotherapy in stage II colorectal cancer (CRC) is controversial as many patients are cured by surgery alone and it is difficult to identify patients with high-risk of recurrence of the disease. There is a need for better stratification of this group of patients. Mass spectrometry imaging could identify patients at risk. We report here the N-glycosylation signatures of the different cell populations in a group of stage II CRC tissue samples. The cancer cells, compared to normal epithelial cells, have increased levels of sialylation and high-mannose glycans, as well as decreased levels of fucosylation and highly branched N-glycans. When looking at the interface between cancer and its microenvironment, it seems that the cancer N-glycosylation signature spreads into the surrounding stroma at the invasive front of the tumor. This finding was more outspoken in patients with a worse outcome within this sample group.

scholarly journals Clinical Impact of Anti-Egfr Monoclonal Antibodies (Egfr Moabs) in Patients with Ras Wild Type (Wt) Metastatic Colorectal Cancer (Mcrc)

2014 ◽  
Vol 25 ◽  
pp. iv185
Author(s):  
F. Pietrantonio ◽  
C. Maggi ◽  
F. Ricchini ◽  
M. Di Bartolomeo ◽  
F.G.M. De Braud ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibodies ◽  
Metastatic Colorectal Cancer ◽  
Clinical Impact ◽  
Wild Type
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