scholarly journals Giovan Battista Foggini e i Viviani: una nuova stagione umanistica per Firenze

2020 ◽  
Vol 1 ◽  
pp. 145-169
Author(s):  
Galanti Tommaso
Keyword(s):  
Seventeenth Century ◽  
Behavioral Model ◽  
Gottfried Wilhelm Leibniz ◽  
Ethical Principles ◽  
Galileo Galilei ◽  
Great Scientist ◽  
Model Based ◽  
Harmonic Proportions ◽  
First Case ◽  
Early Activity

The essay aims to highlight aspects related to thoughts and works of Florentine neo-humanistic culture of the late seventeenth century. We analyze two episodes of Giovan Battista Foggini’s early activity, which was strongly conditioned and determined by the mathematician Vincenzo Viviani. The first case is the facade of Viviani’s private palace, where the scagliola reliefs give shape to the message of the epigraphs on the cartouches. Stoic ethical principles, combined with the adherence to the Jesuit thought, are used to enhance Galileo Galilei and his discoveries, generating a modern mythology aimed at exalting the figure of the great scientist. The second commission that Foggini receives from the Viviani family by the end of the seventeenth century is the palace of the grand-ducal auditor Donato Viviani della Robbia. The architectural solutions adopted by Foggini stem from the legacy of Raphael’s thought concerning geometry and harmonic proportions. At the same time, the internal plastic and pic- torial decoration provides a behavioral model based on the canons of measure and aims at the search for truth: following this vocation, man will be in a position to gain awareness of the universal harmony and to spread it through beauty and pleasure. These concepts, taken from the thought of the Jesuit Sforza Pallavicino, come to Florence through Gottfried Wilhelm Leibniz, with whom Viviani entertained a lively intellectual exchange.

Behavioral-model-based freehand tracking in a Selection-Move-Release system

2014 ◽  
Vol 40 (6) ◽  
pp. 1827-1837 ◽  
Author(s):  
Zhiquan Feng ◽  
Bo Yang ◽  
Haokui Tang ◽  
Na Lv ◽  
Qingfang Meng ◽  
...  
Keyword(s):  
Behavioral Model ◽  
Release System ◽  
Model Based

Repercussions

Security ◽  
2013 ◽  
Author(s):  
John T. Hamilton
Keyword(s):  
Seventeenth Century ◽  
Gottfried Wilhelm Leibniz ◽  
Human Experience ◽  
Blaise Pascal ◽  
Scientific Career ◽  
Political Views ◽  
The Face

This chapter considers Gottfried Wilhelm Leibniz who devoted his philosophic and scientific career to harmonizing discordances and unifying disparities, calculating the otherwise incalculable and reconciling the seemingly unreconciliable. The universalizing thrust of Leibniz's thinking is of a piece both with his ecumenism and with his moral and political views. The Cartesian who rejects phenomena as false simply because they can be doubted lacks the courage to face conflicts that may arise within any aspect of human experience. Instead, Leibniz refused to be daunted by uncertainty. In this regard, he should be numbered among those seventeenth-century theoreticians of probability like Pierre de Fermat, Blaise Pascal, and Jakob Bernoulli, who strove to develop models of rational judgment and action in the face of grave uncertainty.

scholarly journals 1543. Ceftaroline Model-based Dose Individualization in an Infant with Kidney Disease and Mediastinitis

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S563-S563
Author(s):  
Mark Murphy ◽  
Sonya Tang-Girdwood ◽  
Peter Tang ◽  
Brady C Rebecca ◽  
Tomoyuki Mizuno ◽  
...  
Keyword(s):  
Renal Function ◽  
Kidney Disease ◽  
Renal Dysfunction ◽  
Drug Exposure ◽  
Kidney Injury ◽  
Dosing Regimen ◽  
Dose Individualization ◽  
Model Based ◽  
First Case ◽  
High Concentrations

Abstract Background Options for the treatment of infections caused by resistant gram-positive bacteria are limited in children with kidney disease. Ceftaroline (CFD) may be an attractive option but dosing recommendations are not available for children with renal dysfunction. We present a case of pharmacokinetics (PK) model-based individualization of CFD in an infant with kidney disease and mediastinitis. A 5-week-old infant with a hypoplastic left side of the heart developed mediastinitis following a Norwood and BT shunt. Blood and chest washout cultures grew S. epidermidis. Vancomycin therapy led to acute kidney injury (AKI) (eGFR ~15mL/minute) and therefore, CFD was initiated at 8 mg/kg every 12 hours. The model-based clinical service was consulted to assist with dosing. Methods Plasma levels were drawn on day 2 and 10 of CFD. CFD concentrations were determined by HPLC. The pharmacodynamic (PD) target used the MIC of the isolate, 1 µg/mL, and assumed drug diffusion into the mediastinum at 20% of plasma. The PD target was ƒT>MIC at 100%. Individual PK parameters were estimated using Bayesian estimation with MWPharm++ (Mediware, the Netherlands). Results CFD dosing of 8 mg/kg every 12 hours resulted in concentrations well above the target. The trough level was 10 times higher than levels seen in clinical trials. Repeat levels were checked on day 10 due to improved renal function (eGFR 30 mL/minute) and changes in volume status. Changes in both clearance and volume were noted. ƒT>MIC was maintained 100% during dosing intervals. We dose optimized CFD to achieve the target while minimizing potential toxicity with long-term use. A new dosing regimen, 5.4 mg/kg every 8 hours, was started on day 12 and continued for 6 weeks. Conclusion This is the first case report of CFD use in a child with AKI. Though initial dosing resulted in high concentrations, no adverse effects were noted. Successful treatment was completed with a final dosing regimen of 5.3 mg/kg every 8 hours, below the recommended 8 mg/kg every 8 hours. Lower dosing was needed to decrease high drug exposure due to the decreased clearance. This case also demonstrated the feasibility of PK model-based precision dosing within 48 hours, and documented utility in the setting of changes in renal function. Further PK/PD studies are needed in children with renal dysfunction. Disclosures All authors: No reported disclosures.

scholarly journals Proper Orthogonal Decomposition as Surrogate Model for Aerodynamic Optimization

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Valentina Dolci ◽  
Renzo Arina
Keyword(s):  
Proper Orthogonal Decomposition ◽  
Parameter Space ◽  
Surrogate Model ◽  
Orthogonal Decomposition ◽  
High Fidelity ◽  
Aerodynamic Optimization ◽  
Model Based ◽  
Flow Past ◽  
First Case ◽  
Proper Orthogonal

A surrogate model based on the proper orthogonal decomposition is developed in order to enable fast and reliable evaluations of aerodynamic fields. The proposed method is applied to subsonic turbulent flows and the proper orthogonal decomposition is based on an ensemble of high-fidelity computations. For the construction of the ensemble, fractional and full factorial planes together with central composite design-of-experiment strategies are applied. For the continuous representation of the projection coefficients in the parameter space, response surface methods are employed. Three case studies are presented. In the first case, the boundary shape of the problem is deformed and the flow past a backward facing step with variable step slope is studied. In the second case, a two-dimensional flow past a NACA 0012 airfoil is considered and the surrogate model is constructed in the (Mach, angle of attack) parameter space. In the last case, the aerodynamic optimization of an automotive shape is considered. The results demonstrate how a reduced-order model based on the proper orthogonal decomposition applied to a small number of high-fidelity solutions can be used to generate aerodynamic data with good accuracy at a low cost.

Een nieuwe kijk op Franchoys Elaut (I589-I635)

1995 ◽  
Vol 109 (1-3) ◽  
pp. 18-31
Author(s):  
Fred G. Meijer
Keyword(s):  
Seventeenth Century ◽  
The Other ◽  
Poor Condition ◽  
Biographical Research ◽  
Historical Literature ◽  
The Hague ◽  
A Company ◽  
Early Activity

AbstractIn this article a newly researched biography and a fresh look at the small oeuvre of the Haarlem painter Franchoys Elaut - hitherto called 'Elout' in art-historical literature - are presented. Franchoys Elaut was born in August Ι589 into a family that had moved from Ghent to Haarlem, probably some five years earlier. Biographical research is complicated by the fact that between Ι585 and Ι698 ten or eleven persons of the same name, all members of the same family, were registered in Haarlem. Nothing is known about the painter's training and early activity. He may not have started out as a painter; his earliest known work dates from Ι627 (fig. 2), and was therefore painted when he was about thirty-eight. The following year, however, Samuel Ampzing praised Elaut's still lifes in his book about Haarlem. Also in Ι627 a Francois Elaut - probably the painter - was registered as a musketeer in a company of the civic guard and was a witness at the baptism of Frans Hals' son Reinier. In Ι628 Franchoys Elaut married Anneke Jans; daughters were baptised in Ι629 and Ι632. Our painter probably fell victim to the plague that afflicted Haarlem in Ι635: his burial is registered as having taken place on September 22 of that year and in the books of the Haarlem guild for Ι637 he is noted as 'dead'. Art-historical literature has always presented Elaut as a painter of still lifes only, but he produced works in other genres as well. In The Hague a 'tronie', a head of an old man, signed with his monogram and dated Ι632, has surfaced on two occasions (fig. 5). Two such works by Elaut appear to have been offered for sale in Haarlem as early as Ι63Ι, together with five still lifes by the artist. Additionally, two genre paintings in the manner of Dirck Hals, one of which is now in Munich, can be attributed to Franchoys Elaut (fig. 7). Both paintings are in keeping with Haarlem traditions of the time. Of the still lifes hitherto ascribed to Elaut, only two signed examples can be established securely as his work (figs. Ι and 2). These can be supplemented by two more still lifes, one of which- monogrammed and dated Ι630, but unfortunately in poor condition - surfaced quite recently (fig. 3). The other was on the market several times this century as a work by Pieter Claesz. (fig. 4). Both in his still lifes and genre pieces Franchoys Elaut showed himself to be an eager and able follower of the latest stylistic developments and an artist whose works, according to Ampzing's testimony, must have commanded a certain amount of respect in seventeenth-century Haarlem.

Sign in / Sign up

Export Citation Format

Share Document