scholarly journals ID-Migraine is a sensitive tool for screening migraine among patients with multiple sclerosis

2019 ◽  
pp. 2-4
Author(s):  
Marcos Vinícius de Queiroz ◽  
Washington Luiz G. Medeiros Jr ◽  
Audred C. Biondo Eboni ◽  
Eduardo A. Guimaraes Nogueira ◽  
Marcus Vinicius M. Gonçalves ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Demographic Data ◽  
National Study ◽  
High Prevalence ◽  
Id Migraine ◽  
One Year ◽  
Sensitivity Specificity ◽  
Potential Tool ◽  
Ms Therapy

Introduction: Migraine and multiple sclerosis (MS) have been described as comorbidities. While other types of headaches can be seen in patients with MS, it is migraine that usually adds to the burden of patients suffering from an already disabling and chronic neurological disease. Migraine is more prevalent in patients with MS than in the general population, and can be worsened by certain treatments that are used to control MS. ID-migraine is a tool to screen migraine in a population. It consists of only three self-reported questions, and shows good sensitivity, specificity and reliability. The aim of the present study was to assess the role of ID-migraine as a potential tool for screening migraine in patients with MS. Method: Patients diagnosed with MS for at least one year were invited to answer ID-migraine. Demographic data and information on MS therapy were obtained at the same time. Results: Sixty-two patients participated in the study. There were 16 men and 46 women, of average age 35 years. Migraine was identified in 51.5% of them and 18% reported having the characteristics of chronic migraine. ID-migraine showed 93% sensitivity and specificity for migraine in this population. The medication most frequently associated with worsening of previous migraine was interferon beta 1-a (27.4% of the cases). Conclusion: ID-migraine was shown to be a potential tool for identifying migraine in patients with MS. However, the high prevalence of migraine in this population may have constituted a selection bias, since mostpatients without headache may not have felt inclined to participate in this voluntary investigation. The results from this pilot study will be expanded and investigated in more detail in a large national study.

scholarly journals The Role of the Primary-Care Physician in Treating Relapses in Multiple Sclerosis Patients

2009 ◽  
Vol 11 (3) ◽  
pp. 122-126 ◽  
Author(s):  
Sarah A. Morrow ◽  
Marcelo Kremenchutzky
Keyword(s):  
Multiple Sclerosis ◽  
Primary Care ◽  
Primary Care Physicians ◽  
Tertiary Care ◽  
Care Physician ◽  
Diagnosis And Treatment ◽  
High Prevalence ◽  
Tertiary Care Centers ◽  
Multiple Sclerosis Patients

Multiple sclerosis (MS) is a common disabling neurologic disease with an overall prevalence in Canada of 240 in 100,000. Multiple sclerosis clinics are located at tertiary-care centers that may be difficult for a patient to access during an acute relapse. Many relapses are evaluated by primary-care physicians in private clinics or emergency departments, but these physicians' familiarity with MS is not known. Therefore, a survey was undertaken to determine the knowledge and experience of primary-care physicians regarding the diagnosis and treatment of MS relapses. A total of 1282 licensed primary-care physicians in the catchment area of the London (Ontario, Canada) Multiple Sclerosis Clinic were identified and mailed a two-page anonymous survey. A total of 237 (18.5%) responses were obtained, but only 216 (16.8%) of these respondents were still in active practice. Of these 216 physicians, only 9% reported having no MS patients in their practice, while 70% had one to five patients, 16.7% had six to ten, and 1.9% had more than ten (3.7% did not respond to this question). Corticosteroids were recognized as an MS treatment by 49.5% of the respondents, but only 43.1% identified them as a treatment for acute relapses. In addition, 31% did not know how to diagnose a relapse, and only 37% identified new signs or symptoms of neurologic dysfunction as indicating a potential relapse. Despite the high prevalence of MS in Canada, primary-care physicians require more education and support from specialists in MS care regarding the diagnosis and treatment of MS relapses.

scholarly journals A study to evaluate the role of suction drains in orthopedic surgery

1970 ◽  
Vol 9 (2) ◽  
pp. 91-94 ◽  
Author(s):  
GP Khanal ◽  
R Rijal ◽  
BP Shrestha ◽  
NK Karn ◽  
P Chaudhary
Keyword(s):  
Beneficial Effect ◽  
Orthopedic Surgery ◽  
Postoperative Infection ◽  
Wound Care ◽  
Demographic Data ◽  
Superficial Infection ◽  
Postoperative Wound ◽  
Suction Drain ◽  
One Year

Background: There is controversy in routine use of suction drain in orthopedic surgeries. Devastating postoperative infection and years of treatment had forced on extra measures of postoperative wound care and use of drains. Objective: To find out the necessity of intraoperative drains in routine orthopedic surgery. Methods: Thirty patients were enrolled in the study. All of the patients were followed up on 2nd, 14th days and 3 monthly till one year of period. All the demographic data and preoperative investigations and intraoperative and postoperative parameters were recorded in standard proforma. Data were analysed using appropriate statistical method. Results: All the patients were followed up to one year period. Six patients had superficial infection on 2nd postoperative day. They were managed with antibiotics and no patient showed signs of infections on 14th postoperative day and thereafter. No patient needed postoperative reinforcement of dressing. Conclusion: Routine use of intraoperative drain in hip surgeries has beneficial effect of decreasing reinforcement of postoperative dressing. Keywords: orthopedic surgery; suction drain; BPKIHS DOI: http://dx.doi.org/10.3126/hren.v9i2.4980 Health Renaissance 2011: Vol.9 (No.2): 91-94

Is There a Case for a Virus Aetiology in Multiple Sclerosis?

1995 ◽  
Vol 40 (2) ◽  
pp. 55-62 ◽  
Author(s):  
Bernard E. Souberbielle ◽  
Paul W.S. Szawlowski ◽  
William C. Russell
Keyword(s):  
Multiple Sclerosis ◽  
Demyelinating Disease ◽  
Autoimmune Response ◽  
Aggressive Approach ◽  
Shetland Islands ◽  
North East ◽  
High Prevalence ◽  
Specific Virus ◽  
Very High

Multiple Sclerosis (MS) is a devastating demyelinating disease with a very high prevalence in North-East Scotland and in the Orkney and Shetland Islands. MS appears to be a multifactorial disorder with environmental and genetic elements and it has been proposed that these, in tandem, provoke an autoimmune response giving rise to the disease. Although there is no direct evidence of a specific virus being involved in MS, there are nevertheless grounds for suspecting a viral association. This review discusses these aspects of MS and suggests that a more aggressive approach to unravelling the role of viruses is needed.

THE PROFILE OF MULTIPLE SCLEROSIS IN GENERAL PRACTICE

2015 ◽  
Vol 86 (11) ◽  
pp. e4.6-e4
Author(s):  
Sophie Binks ◽  
Liz Green
Keyword(s):  
Multiple Sclerosis ◽  
Primary Care ◽  
Team Approach ◽  
Improvement Project ◽  
Flu Vaccination ◽  
The Mean ◽  
One Year ◽  
Primary Care Professionals

IntroductionMultiple sclerosis (MS) is a long-term neurological condition requiring a multi-disciplinary team approach. Recently, NICE highlighted the role of primary care professionals in MS management through an updated clinical guideline. This quality improvement project investigated aspects of MS patient care in a large Brighton GP practice.MethodElectronic GP records were searched to identify all currently registered patients with a diagnosis of MS. Details of initial presentation, epidemiology and care received over a one-year period were examined.ResultsThere were 19 patients, representing a prevalence of 186 per 100,000. Most patients first presented in GP with sensory disturbance, optic neuritis or motor symptoms. The mean number of primary care contacts per patient per year was 4.3, compared to 0.4 contacts per person per year with a neurologist and 0.5 with the MS nurse. 46% of GP consultations were wholly or partially related to the patient's MS. Around half of patients took up proactive interventions such as flu vaccination (47%) and Vitamin D monitoring (50%).ConclusionsPrimary care professionals are significant contributors to the care of people with MS with frequent patient contact. During this project, patients were reminded of preventive care opportunities and this will be re-audited in 2015.

The role of Toll-like receptors in multiple sclerosis and possible targeting for therapeutic purposes

2014 ◽  
Vol 0 (0) ◽  
Author(s):  
Maziar Gooshe ◽  
Amir Hossein Abdolghaffari ◽  
Maria Elsa Gambuzza ◽  
Nima Rezaei
Keyword(s):  
Multiple Sclerosis ◽  
Host Defense ◽  
Toll Like Receptors ◽  
Autoimmune Encephalomyelitis ◽  
Pathological Conditions ◽  
The Central Nervous System ◽  
Chronic Autoimmune Disease ◽  
Ms Therapy ◽  
Experimental Autoimmune

AbstractThe interaction between the immune and nervous systems suggests invaluable mechanisms for several pathological conditions, especially neurodegenerative disorders. Multiple sclerosis (MS) is a potentially disabling chronic autoimmune disease, characterized by chronic inflammation and neurodegenerative pathology of the central nervous system. Toll-like receptors (TLRs) are an important family of receptors involved in host defense and in recognition of invading pathogens. The role of TLRs in the pathogenesis of autoimmune disorders such as MS is only starting to be uncovered. Recent studies suggest an ameliorative role of TLR3 and a detrimental role of other TLRs in the onset and progression of MS and experimental autoimmune encephalomyelitis, a murine model of MS. Thus, modulating TLRs can represent an innovative immunotherapeutic approach in MS therapy. This article outlines the role of these TLRs in MS, also discussing TLR-targeted agonist or antagonists that could be used in the different stages of the disease.

scholarly journals Prediction of probable impact of miR-34a and miR-215 on differentiation of naive CD4+ T cells to Th17 cells in multiple sclerosis

2018 ◽  
Vol 21 (6) ◽  
pp. 276-279
Author(s):  
Nooshin Ghadiri ◽  
Aref Hoseini ◽  
Kamran Ghaedi ◽  
Negar Alsadat Emamnia ◽  
Mazdak Ganjalikhani-Hakemi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Th17 Cells ◽  
Therapeutic Approaches ◽  
Diagnostic Biomarkers ◽  
Cellular Processes ◽  
High Prevalence ◽  
Probable Impact ◽  
Non Coding Rnas ◽  
Th17 Differentiation

Background and aims: miRNAs, as a class of non-coding RNAs, take part in different cellular processes. Dysregulation of different miRNAs has been reported in numerous disorders to date. Multiple sclerosis (MS) is an autoimmune disease with high prevalence in Iran and Th17 cells play an important role in its pathogenesis. In the current study, we aimed to predict the possible role of miR-34a and miR-215 in the process of controlling Th17 differentiation, and hence, their possible impact on the onset and progression of MS. Methods: We investigated probable interactions of miRNAs and genes that participate in Th17 cells differentiation using miRwalk database as an integrative one which utilizes 10 different algorithms to predict miRNA-mRNA interaction. Results: Based on our findings, miR-34a and miR-215 were predicted to have a potential role in the induction of Th17 cells differentiation. Conclusion: Conclusively, miR-34a and miR-215 may up-regulate Th17 cells of MS patients. Since bioinformatics data have shown that these miRNAs suppress negative regulatory genes in Th17 cells differentiation, we suppose that down-regulation of these miRNAs could ameliorate MS symptoms. Therefore, several therapeutic approaches may be considered for these miRNAs besides their application as valuable prognostic/diagnostic biomarkers in detection of various stages of MS.

Determination of the cytotoxic activity of Campylobacter strains isolated from bovine and swine carcasses in north-eastern Poland

2015 ◽  
Vol 18 (3) ◽  
pp. 579-586 ◽  
Author(s):  
B. Wysok ◽  
J. Uradziński ◽  
J. Wojtacka
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Hela Cells ◽  
Pcr Analysis ◽  
High Prevalence ◽  
North Eastern ◽  
One Year ◽  
Human Infections

Abstract The study was carried out to determine the cytotoxin production by Campylobacter spp. isolated from slaughtered cattle and swine in north-eastern Poland. In total three commercial slaughterhouses were sampled during one year. Carcass swabs were taken to detect the level of Campylobacter spp. contamination. Campylobacter spp. was found in 50 (34%) out of 147 swine carcasses examined. PCR analysis revealed 4 (8%) isolates to be C. jejuni, and 46 (92%) to be C. coli. From a total of 373 bovine carcasses, Campylobacter spp. were isolated from 49 (13.1%) samples. The results regarding the occurrence of cdt genes associated with cytotoxicity indicated that 100% of C. jejuni and 67.4% C. coli obtained from pigs had all three cdtA, cdtB and cdtC genes. In case of C. jejuni strains isolated from cattle all cdt genes were confirmed in 93.9% isolates. The isolates possessesing all cdt genes had higher cytotoxic activity against cell lines used. The isolates both from cattle and swine were characterized by the highest cytotoxicity against HeLa cells. The values obtained reached 80.8% for C. jejuni isolates from cattle and 76.2% for C. jejuni and 69.0% for C. coli isolates from swine. High prevalence of cytotoxicity in Campylobacter spp. indicates a significant epidemiological role of this pathogen in human infections.

scholarly journals SARS-CoV-2 Infection in Multiple Sclerosis

2021 ◽  
Vol 8 (5) ◽  
pp. e1024
Author(s):  
Georgina Arrambide ◽  
Miguel Ángel Llaneza-González ◽  
Lucienne Costa-Frossard França ◽  
Virginia Meca-Lallana ◽  
Eva Fernández- Díaz ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Critical Role ◽  
Fatal Outcome ◽  
Severe Infection ◽  
Disease Course ◽  
Immunocompromised State ◽  
Death Cases ◽  
Ms Therapy ◽  
Older Males

ObjectiveTo understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments.MethodsRetrospective and multicenter registry in patients with MS with suspected or confirmed COVID-19 diagnosis and available disease course (mild = ambulatory; severe = hospitalization; and critical = intensive care unit/death). Cases were analyzed for associations between MS characteristics and COVID-19 course and for identifying risk factors for a fatal outcome.ResultsOf the 326 patients analyzed, 120 were cases confirmed by real-time PCR, 34 by a serologic test, and 205 were suspected. Sixty-nine patients (21.3%) developed severe infection, 10 (3%) critical, and 7 (2.1%) died. Ambulatory patients were higher in relapsing MS forms, treated with injectables and oral first-line agents, whereas more severe cases were observed in patients on pulsed immunosuppressors and critical cases among patients with no therapy. Severe and critical infections were more likely to affect older males with comorbidities, with progressive MS forms, a longer disease course, and higher disability. Fifteen of 33 patients treated with rituximab were hospitalized. Four deceased patients have progressive MS, 5 were not receiving MS therapy, and 2 were treated (natalizumab and rituximab). Multivariate analysis showed age (OR 1.09, 95% CI, 1.04–1.17) as the only independent risk factor for a fatal outcome.ConclusionsThis study has not demonstrated the presumed critical role of MS therapy in the course of COVID-19 but evidenced that people with MS with advanced age and disease, in progressive course, and those who are more disabled have a higher probability of severe and even fatal disease.

Prevalence of Primary Headaches in People with Multiple Sclerosis

Cephalalgia ◽  
2004 ◽  
Vol 24 (11) ◽  
pp. 980-984 ◽  
Author(s):  
D D'Amico ◽  
L La Mantia ◽  
A Rigamonti ◽  
S Usai ◽  
N Mascoli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
International Headache Society ◽  
Primary Headache ◽  
Tension Type Headache ◽  
Primary Headaches ◽  
Exact Test ◽  
Relapsing Remitting ◽  
Type Headache ◽  
Ms Therapy

The aim was to investigate the lifetime prevalence of headache and primary headache (diagnoses according to International Headache Society criteria) in multiple sclerosis (MS). The relationships between headache and clinical features of MS and MS therapy were also investigated. We studied 137 patients with clinically definite MS; 88 reported headache, 21 of whom developed headache after the initiation of interferon. The prevalence of all headaches in the remaining 116 patients was 57.7%. Migraine was found in 25.0%, tension-type headache in 31.9%, and cluster headache in one patient. A significant correlation ( P = 0.007, Fisher's exact test) between migraine and relapsing-remitting MS was found. Primary headaches are common in MS patients. Further studies are needed to clarify the mechanisms underlying this association, particularly the association between migraine and relapsing-remitting MS, and the role of interferon in the development of new headache.

scholarly journals A diabetes, a stressz és az alvásproblémák kapcsolata a Hungarostudy 2013 kutatás adatainak fényében

2019 ◽  
Vol 160 (47) ◽  
pp. 1872-1880 ◽  
Author(s):  
Ágnes Vincze ◽  
Laura Kertész ◽  
Edit Czeglédi
Keyword(s):  
Perceived Stress ◽  
Sleep Problems ◽  
Demographic Data ◽  
Survey Method ◽  
Diabetic Patients ◽  
Health Issues ◽  
Cross Sectional ◽  
Treatment Of Diabetes ◽  
One Year

Abstract: Introduction: The problem of diabetes worldwide raises increasingly serious public health issues in Hungary. In recent years, the emphasis on obesity as a primary cause of diabetes has been driven by a complex understanding of the causes of civilization: the role of sleep problems and stress in the development of the disease and the aggravation of the condition has been proven and supported. Aim: The aim of the study was to investigate the relationship between stress, sleep problems and diabetes in the representative Hungarostudy 2013 survey. Method: In the cross-sectional questionnaire study, 2000 adults participated. Mean of age was 46.9 (SD = 18.24) years. The average BMI was 26.0 (SD = 4.97) kg/m2. Measures: socio-demographic data, question about the presence of treated diabetes, symptomatic list, Perceived Stress Scale. Results: The frequency of diabetes treated one year before the date of the survey was 8.2%. The levels of stress experienced by diabetic patients were significantly higher than those experienced by participants not treated with diabetes (t(1944) = –2.586, p = 0.010). After adjusting potential background variables, perceived stress shows a marginally significant relationship with diabetes (OR = 1.03, p = 0.052). 26.0% of the respondents reported sleep problems last month, while 40.2% of them reported fatigue and energy shortages. The presence of sleep problems (χ2(2) = 61.108, p<0.001) and feeling of fatigue or lack of energy (χ2(2) = 51.061, p<0.001) are significantly more frequent among people with diabetes. Treated diabetes also predicts the presence of sleep problems (OR = 1.77, p = 0.003) as well as fatigue and lack of energy (OR = 1.88, p = 0.004) under the control of potential background variables. Conclusion: Our results show that, according to trends in other parts of the world, both sleep problems and stress play a significant role in the development of diabetes in Hungary. This draws attention to the need for effective screening and treatment of these factors in the prevention and treatment of diabetes in accordance with international protocols. Orv Hetil. 2019; 160(47): 1872–1880.

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