scholarly journals Recent Developments in Coumarin Derivatives for Breast Cancer Therapy

2020 ◽  
pp. 287-305
Author(s):  
Gauri alias Pooja M. Naik ◽  
Omkar D. Paradkar ◽  
Aarti M. Naik ◽  
Shamali S. Rane ◽  
Deepashree D. Dalvi ◽  
...  
Keyword(s):  
Medical Specialty ◽  
Ring System ◽  
Selective Oestrogen Receptor Modulators ◽  
Recent Developments ◽  
Drug Treatments ◽  
Cancer Agent ◽  
Receptor Modulators ◽  
Breast Tissues ◽  
Anti Hiv ◽  
Coumarin Ring

The coumarin ring system (benzopyran-2-one, or chromen-2-one), gift in natural shown fascinating medical specialty properties, has intrigued chemists to explore the natural coumarins or artificial analogs for his or her relevance as medication. uncountable molecules supported the coumarin ring system are synthesized within the laboratories utilizing completely different artificial techniques. the variety orientating artificial routes have crystal rectifier to fascinating derivatives together with the furanocoumarins, pyranocoumarins, and coumarin sulfamates, that are found to be helpful in photochemotherapy, antitumour and anti-HIV medical care, and conjointly as stimulants for central systema nervosum, anti-inflammatory drug, anti-coagulants, medicament and dyes. In carcinoma therapy, some coumarins and their active matter 7-hydroxycoumarin derivatives have shown sulfatase and aromatase restrictive activities. Coumarin primarily based selective oestrogen receptor modulators (SERMs) and coumarin oestrogen conjugates have conjointly been expressed as an excellent potential antibreast cancer agent. carcinoma is leading reason behind death in ladies, there's a powerful focus to spot potential new drug treatments for carcinoma. Therefore, the most objective of this review is to specialise in vital coumarin analogs with antibreast cancer activities, highlight their mechanisms of action and structure-activity relationships on elect receptors in breast tissues.

2,4-Diphenyl-2-(trimethylsilyloxy)-3-dihydro-2H,5H-pyrano[3,2-c][1]benzopyran-5-one

2006 ◽  
Vol 62 (4) ◽  
pp. o1397-o1398
Author(s):  
Yun Liu ◽  
Yong-Miao Shen ◽  
Zhe Li ◽  
Jian-Hua Xu
Keyword(s):  
Title Compound ◽  
Chair Conformation ◽  
Ring System ◽  
Pyran Ring ◽  
Compound C ◽  
Coumarin Ring

In the title compound, C27H26O4Si, the coumarin ring system is essentially planar and the pyran ring adopts a half-chair conformation.

Triazole As Potent Anti-Cancer Agent- A Pharmacophoric Scaffold

2021 ◽  
Vol 17 ◽  
Author(s):  
Nidhi Kala ◽  
Kalpana Praveen Rahate
Keyword(s):  
Characteristic Feature ◽  
Biological Activities ◽  
Heterocyclic Ring ◽  
Ring System ◽  
Review Article ◽  
Current Review ◽  
Anti Cancer ◽  
Good Template ◽  
Cancer Agent

: Triazole is the main five-membered Nitrogen-containing basic heterocyclic ring system reported for their biological activities and compounds with multiple pharmacophores, which fetch together acquaintance of a target with sympathetic types of the molecule that might interact with the target. In addition, healthy, adaptable, and scalable chemistry must be employed to achieve the task. This characteristic feature of triazole would make a good template for a lead cohort library. The current review article focuses on recent advancements in triazole moiety as an anti-cancer agent with their mechanism pathways of synthesized analogues.

scholarly journals Synthesis and Biological Activities of Some Pyrimidine Derivatives: A Review

2020 ◽  
Vol 36 (6) ◽  
pp. 1001-1015
Author(s):  
Nadia Ali Ahmed Elkanzi
Keyword(s):  
Nitrogen Atom ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Heterocyclic Ring ◽  
Ring System ◽  
Pyrimidine Derivatives ◽  
Pharmacological Activities ◽  
Cardiovascular Agents ◽  
Anti Hiv ◽  
Biological And Pharmacological Activities

Nitrogen containing synthetically and biologically important heterocyclic ring system namely pyrimidine possess both biological and pharmacological activities, and defend as aromatic six heterocyclic with 1and 3 nitrogen atom in ring. Preparation of pyrimidine via different methods offer its importance in fields of medicinal chemistry and Chemistry. Pyrimidines and their derivatives act as anti-inflammatory, anti-malaria, anti-tumor, cardiovascular agents, anti-neoplastic, anti-tubercular, anti- HIV, diuretic ,anti-viral, anti-microbial, ,analgesic .This review give light up on biological and pharmacological activities of pyrimidine nucleus.

scholarly journals 6-Methyl-4-{[4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl]methyl}-2H-chromen-2-one

IUCrData ◽  
2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Sowmiya Carmel Y. ◽  
N. L. Prasad ◽  
Noor Shahina Begum ◽  
Hari Prasad Suresh
Keyword(s):  
Dihedral Angle ◽  
Title Compound ◽  
Triazole Ring ◽  
Ring System ◽  
Compound C ◽  
Coumarin Ring

In the title compound, C16H19N3O2Si, the dihedral angle between the coumarin ring system (r.m.s. deviation = 0.031 Å) and the triazole ring is 73.81 (8)°. In the crystal, molecules are linked into [010] chains by weak C—H...O interactions.

scholarly journals Clinically used selective oestrogen receptor modulators increase LDL receptor activity in primary human lymphocytes

2015 ◽  
Vol 172 (5) ◽  
pp. 1379-1394 ◽  
Author(s):  
F Cerrato ◽  
M E Fernández-Suárez ◽  
R Alonso ◽  
M Alonso ◽  
C Vázquez ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Human Lymphocytes ◽  
Ldl Receptor ◽  
Receptor Activity ◽  
Selective Oestrogen Receptor Modulators ◽  
Receptor Modulators

scholarly journals Tubeimoside-1, Triterpenoid Saponin, as a Potential Natural Cancer Killer

2018 ◽  
Vol 13 (5) ◽  
pp. 1934578X1801300
Author(s):  
Muhammad Zafar ◽  
Iqra Sarfraz ◽  
Azhar Rasul ◽  
Faiza Jabeen ◽  
Khizar Samiullah ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Current Status ◽  
Proliferative Potential ◽  
Triterpenoid Saponin ◽  
Cycle Arrest ◽  
Anti Cancer ◽  
Recent Developments ◽  
Reported Data ◽  
Multiple Signaling ◽  
Anti Hiv

Nature, an expert craftsman of molecules, has generated extensive array of bioactive molecular entities. It persists as an inexhaustible resource for discovery of drugs and supplied enormous scaffold diversification for development into effectual drugs to treat multiple pathological conditions. This review provides an update on the sources, biological, and pharmacological effects of nature's gift, a triterpenoid saponin, tubeimoside-1 which is a major bioactive constituent of the bulb of Bolbostemma paniculatum. Tubeimoside-1 is known to possess various pharmacological properties such as anti-cancer, anti-HIV, and anti-inflammatory. Recently, anti-proliferative potential of tubeimoside-1 has been widely studied. The present review article seeks to cover the recent developments of tubeimoside-1′s pharmacological position in the arena of herbal drugs, providing an insight into its current status in therapeutic pursuits. This anti-cancer triterpenoid saponin fight cancer progression by induction of apoptosis, cell cycle arrest, and inhibiting metastasis by specifically targeting multiple signaling pathways those are usually deregulated in various cancers. The reported data recommend tubeimoside-1′s mutitarget activity in preference to single effect that may perform an imperative role towards developing tubeimoside-1 into potential pharmacological drug.

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