The effect of CDED diet on the development of remission in a patient with persistent Crohn’s disease activity – a case report and workplace experience

2021 ◽  
Vol 75 (4) ◽  
pp. 345-349
Author(s):  
Klára Matušinská ◽  
Barbora Pipek ◽  
Andrea Fialová ◽  
Petr Fojtík
Keyword(s):  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Elimination Diet ◽  
Workplace Experience ◽  
History Of ◽  
Exclusion Diet ◽  
Alternative Nutrition

The CDED diet (Crohn‘s disease exclusion diet) is the first elimination diet that induces and maintains remission in adult patients with mild to moderate Crohn‘s disease. It is based on mandatory, recommended and prohibited foods. In our article we present our workplace experience, that is still limited, as well as the case report of a patient with a long history of Crohn‘s disease in ileocecal localization on immunosuppressive therapy with azathioprine. He has benefited significantly from the CDED diet, his abdominal symptomatology and laboratory parameters have improved. There has also been a significant improvement in the quality of his life. Key words: CDED – Crohn’s disease – diet – alternative nutrition – relapse of the disease

S1209 Does Self-Reported Quality of Life Correlate with Disease Activity in All Crohn's Disease Patients?

2008 ◽  
Vol 134 (4) ◽  
pp. A-201-A-202
Author(s):  
Mazen Issa ◽  
Ashwin N. Ananthakrishnan ◽  
Dawn B. Beaulieu ◽  
Mark Mulcaire-Jones ◽  
Joshua F. Knox ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity

Clinical Correlates of Urolithiasis in Ankylosing Spondylitis

2011 ◽  
Vol 38 (9) ◽  
pp. 1953-1956 ◽  
Author(s):  
NAI LEE LUI ◽  
ADELE CARTY ◽  
NIGIL HAROON ◽  
HUA SHEN ◽  
RICHARD J. COOK ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Ankylosing Spondylitis ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Functional Disability ◽  
Spinal Mobility ◽  
Joint Involvement ◽  
Control Group ◽  
Significant Difference ◽  
History Of

Objective.To determine the association between urolithiasis and syndesmophyte formation and the effect of urolithiasis on ankylosing spondylitis (AS) disease activity.Methods.In a longitudinal cohort of 504 patients with AS, we conducted an analysis of all patients with AS who have a history of urolithiasis. All patients met the modified New York criteria for AS. Demographics, clinical characteristics, extraarticular features, and comorbidities are systematically recorded in the database. We compared disease activity, functional indices, medical therapy and radiographic damage between AS patients with (Uro+) and without urolithiasis (Uro–) using the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS).Results.Thirty-eight patients with AS (7.5%) had a history of urolithiasis in our cohort. Seventy-six patients with AS who did not have urolithiasis, matched for age, sex, and ethnicity, were selected as controls. Patients who were Uro+ were more likely to have more functional disability, based on the Bath AS Functional Index (BASFI; mean 5.3 vs 3.6 in control group, p = 0.003). Trends were noted in the Uro+ group toward higher Bath AS Disease Activity Index (BASDAI; mean 4.9 vs 4.0, p = 0.09), more peripheral joint involvement (p = 0.075), and higher frequency of biologic therapy (p = 0.09). No significant difference was detected in mSASSS or the Bath AS Metrology Index (BASMI). Significant association with diabetes mellitus (DM; p = 0.016) and Crohn’s disease (p = 0.006) was noted in the Uro+ group.Conclusion.Although there is no acceleration of syndesmophyte formation or spinal mobility restriction, more functional disability was detected in the urolithiasis group. The higher risk with concomitant DM or Crohn’s disease should alert clinicians to these comorbidities in Uro+ patients with AS.

Prospective assessment of Cleveland Global Quality of Life (CGQL) as a novel marker of quality of life and disease activity in Crohn'S disease

2003 ◽  
Vol 98 (8) ◽  
pp. 1783-1789 ◽  
Author(s):  
Ravi P. Kiran ◽  
Conor P. Delaney ◽  
Anthony J. Senagore ◽  
Bridget O'Brien-Ermlich ◽  
Edward Mascha ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Global Quality ◽  
Global Quality Of Life ◽  
Prospective Assessment

Quality of life and disease activity in patients with crohn’s disease

2018 ◽  
Vol 37 ◽  
pp. S98
Author(s):  
I. Cioffi ◽  
N. Imperatore ◽  
O. Di Vincenzo ◽  
A. Testa ◽  
R. Sammarco ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity

P049 RESPONSIVENESS OF THE PATIENT-REPORTED OUTCOME MEASUREMENT INFORMATION SYSTEM (PROMIS) TO CHANGES IN DISEASE STATUS AND QUALITY OF LIFE AMONG PEDIATRIC PATIENTS WITH CROHN’S DISEASE

2020 ◽  
Vol 26 (Supplement_1) ◽  
pp. S66-S66
Author(s):  
Erica Brenner ◽  
Millie Long ◽  
Courtney Mann ◽  
Wenli Chen ◽  
Camila Reyes ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Peer Relationships ◽  
Outcome Measurement ◽  
Disease Status ◽  
Patient Reported Outcome ◽  
Measurement Information ◽  
Patient Reported

Abstract Background Patient Reported Outcome Measurement Information System (PROMIS) provides valid, self-reported measures of physical, emotional, and social health that can inform research and clinical care in children with chronic conditions. Prior research in pediatric Crohn’s disease (CD) has demonstrated robust correlations between PROMIS and disease activity. However, responsiveness, defined as sensitivity to clinical change, has not been yet been thoroughly evaluated. Aims We sought to evaluate the responsiveness of the PROMIS Pediatric measures relative to changes in 1) disease activity and 2) disease-specific health-related quality of life (HRQOL). Methods IBD Partners Kids & Teens is an internet-based cohort of children with IBD. Participants age 9 to 17 report symptoms related to disease activity [Short Crohn’s Disease Activity Index (SCDAI)], the IMPACT III HRQOL measure, and PROMIS domains of Anxiety, Depression, Pain Interference, Fatigue, and Peer Relationships. We conducted longitudinal analyses using mixed linear models to examine the extent to which PROMIS measures were responsive to changes in SCDAI and IMPACT III, adjusting for time and taking into account the clustering of individual participants. A change threshold of 70 points in SCDAI was used as a minimally important difference (MID). We also graphically depicted changes in PROMIS domains corresponding to improved, stable, or worsened disease activity and evaluated changes in PROMIS versus changes in IMPACT III using Pearson’s correlation. Results Our study sample included 544 participants with CD (mean age 13 years, 44% female) from 44 states. All PROMIS domains were responsive to changes in SCDAI, indicating improved physical, emotional, and social health corresponding to improved disease activity (Table 1, p< 0.001). Observed effect estimates ranged from 1.9 for Peer Relationships to 6.9 for Fatigue, in line with estimates of MID in both adult IBD and other pediatric chronic conditions. Of 246 participants with 2 or more completed reports (689 pairs of consecutive reports), disease activity was stable in 527, worse in 72, and improved in 67. Figure 1 demonstrates changes in PROMIS scores as a function of change in disease activity. Changes in PROMIS scores were also strongly associated with changes in IMPACT 35 scores (R=-0.5 for Anxiety, R=-0.5 for Depression, R=-0.6 for Pain Interference, R= -0.7 for Fatigue, and R=0.35 for Peer Relationships). Conclusion This study provides evidence for the longitudinal responsiveness of the PROMIS Pediatric measures to change in disease status and HRQOL in pediatric CD patients. The results support use of the PROMIS Pediatric measures in clinical outcomes research.

scholarly journals Impact of Disease Activity on the Quality of Life of Crohn’s Disease Patients

1996 ◽  
Vol 10 (5) ◽  
pp. 310-315 ◽  
Author(s):  
T Michael Vallis ◽  
Geoffrey K Turnbull
Keyword(s):  
Quality Of Life ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Activity Index ◽  
Bowel Symptoms ◽  
Systemic Symptoms ◽  
Disease Specific ◽  
Over Time

Crohn’s disease (CD) patients often suffer severe symptoms that impair their quality of life. A sample of 39 CD patients who were assessed using well validated measures of disease activity and disease-specific quality of life is reported. Twenty-six of these patients were reassessed an average of four months after the initial assessment to determine the impact of changes in disease activity on quality of life. For the total sample (n=39) disease activity did not predict quality of life for any of the scales of the Inflammatory Bowel Disease Questionnaire (IBDQ) (r<0.13 for each). Thus, examining fluctuations in disease activity between patients did not demonstrate a disease activity-quality of life relationship. In contrast, changes in disease activity within the same individuals over time (the repeat assessment sample, n=26) were correlated with changes in quality of life; increases in disease activity predicted decreases in quality of life on the IBDQ bowel symptoms subscale (r=-0.463, P<0.01) and the IBDQ systemic symptoms subscale (r=0.44, P<0.05). The 10 patients with the largest decrease in disease activity over time (mean decrease of 43.54 points using the Dutch Activity Index) had significant improvement in quality of life on the bowel and systemic subscales. In contrast, the nine patients with the largest increase in disease activity over time (mean increase of 20.57 points using the Dutch Activity Index) had significant reduction in quality of life on the bowel and systemic symptoms subscales. These differences between extreme groups were significant for both the bowel symptoms (P<0.05) and systemic symptoms (P<0.05) subscales. The authors conclude that changes in disease activity affect some important aspects of quality of life: aspects related to disease-specific (bowel symptoms) and nondisease-specific (systemic symptoms) physical symptoms. Importantly, disease activity was not able to predict the emotional and social aspects of IBD-related quality of life. This suggests that nondisease factors need to be considered when working with CD patients. Future research should evaluate the role of psychological intervention in improving quality of life for patients with reduced well-being, particularly in areas of emotional and social functioning.

scholarly journals Reply to Cantarelli et al. Chronic Recurrent Multifocal Osteomyelitis Associated with Crohn Disease: A Potential Role of Exclusion Diet? Comment on “Starz et al. The Modification of the Gut Microbiota via Selected Specific Diets in Patients with Crohn’s Disease. Nutrients 2021, 13, 2125”

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4007
Author(s):  
Eliza Starz ◽  
Karolina Wzorek ◽  
Marcin Folwarski ◽  
Karolina Kaźmierczak-Siedlecka ◽  
Laura Stachowska ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Gut Microbiota ◽  
Crohn Disease ◽  
Potential Role ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Multifocal Osteomyelitis ◽  
Exclusion Diet

We congratulate Erika Cantarelli and colleagues for the presented case report in the comment entitled “Chronic Recurrent Multifocal Osteomyelitis associated to Crohn Disease (CD): a potential role of exclusion diet [...]

scholarly journals Quality of Life of Children with Crohn’s Disease as a Potential Criterion for Monitoring Disease Activity

Doctor Ru ◽  
2020 ◽  
Vol 19 (10) ◽  
pp. 27-32
Author(s):  
А.R. Tahirova ◽  
◽  
I.V. Sichinava ◽  
O.F. Savvateeva ◽  
E.V. Borisova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Psychosocial Functioning ◽  
Activity Index ◽  
Extraintestinal Manifestations ◽  
Pedsql 4.0

Study Objective: To analyse the activity dynamics of Crohn’s disease (CD) and the quality of life (QoL) of children aged 8–17 years. Study Design: Open prospective non-randomized comparative study. Materials and Methods. The quality of life was assessed in 37 healthy children and 28 children with Crohn's disease (17 boys and 11 girls). Disease activity (Paediatric Crohn’s Disease Activity Index, PCDAI) was determined using PedsQL 4.0 Generic Core Scales questionnaire which comprises assessment of health and activity, child’s attitude, problems with interpersonal relations, and progress at school. Observation spanned over 18 months; tests parameters were assessed at the beginning (first visit), after 6, 12 and 18 months. QoL was assessed by both children and their parents, the indicators were assessed over time and compared with the levels of activity, the duration of the disease, and the presence of extraintestinal manifestations of the disease. Study Results. Children with CD aged 8–17 years demonstrated a decrease in the majority of PedsQL 4.0 parameters. The shifts are observed both when QoL is assessed by children and their parents. The therapy in these patients is accompanied by positive QoL dynamics; these changes occur in parallel with a decrease in the values of the CD activity index, suggesting the possibility of using the QoL parameters to predict the course of the disease and the effectiveness of the treatment in this population. PCDAI values in subjects demonstrated moderate statistically significant negative correlations with “Physical activity” (r = –0.412), “Attitude” (r = –0.364), “Psychosocial functioning” (r = –0.306) and “School life” (r = –0.344) and the overall PedsQL 4.0 values (r = –0.406). The duration of the disease has statistically significant negative correlation with “Physical activity” (r = –0.386), “Attitude” (r = –0.423), “Psychosocial functioning” (r = –0.345), and the integral PedsQL 4.0 value (r = –0.397); the presence of extraintestinal manifestations demonstrated moderate negative correlation with “Physical activity” (r = –0.342), “School life” (r = –0.431) and overall value (r = –0.372). Conclusion. Monitoring of the health-related quality of life should become a mandatory component of the examination and management of children with inflammatory bowel diseases, since this category of patients is characterized by a significant decrease relative to the corresponding indicators in healthy peers. Keywords: inflammatory bowel disorder, Crohn’s disease, quality of life, disease activity, extraintestinal manifestations.

scholarly journals P235 Major Depression in patients with Crohn’s disease and its relationship with clinical activity and disease’s phenotype

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S282-S283
Author(s):  
C Facanali ◽  
N Sousa Freitas Queiroz ◽  
M R Facanali ◽  
L Rodrigues Boarini ◽  
J L Amuratti Gonçalves ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Crohn’S Disease ◽  
Depressive Symptoms ◽  
Major Depression ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Demographic Characteristics ◽  
Clinical Activity ◽  
Disease Phenotype

Abstract Background Crohn’s disease (CD) has a considerable impact on quality of life and contributes to the onset of depressive symptoms¹. It has been demonstrated that depression is more prevalent in inflammatory bowel disease (IBD) patients compared to the general population². However, whether depression affects IBD course or the onset of IBD triggers psychological disorders remains to be elucidated. The aim of the study is to estimate the prevalence of major depression in patients with CD and to evaluate its relationship with the clinical activity and phenotype of the disease. Methods From November 2019 to February 2020, 283 patients with CD were evaluated using the Patient Heath Questionnaire-9 (PHQ-9). Major depression (MD) was defined by PHQ-9 ≥ 10 (0–4: absent depressive symptoms / 5–9: mild depressive symptoms / 10–14: moderate depressive symptoms / 14- 27: severe depressive symptoms). Data regarding socio-demographic characteristics, disease phenotype, clinical activity were prospective collected. Disease phenotype was characterized according to the Montreal classification and clinical activity was assessed using the Harvey-Bradshaw index (HBI). Statistical tests were performed with a 5% significance level. Results The prevalence of MD in CD patients was 41.7% (Table 1). Female patients were more susceptible to MD (Table 2). Other socio-demographic characteristics did not increase the risk of MD. Disease activity was significantly associated with an increased risk of MD (Odds Ratio [OR] 795.97, 95% confidence interval [CI] 133.7–4738.78, p &lt;0.001) (Table 2). Regarding disease phenotype, the stenosing and penetrating behaviour were associated with a lower risk of MD (OR 0.8, 95%CI 0.01-.5 and OR 0.03, 95%CI 0.00–0.18), respectively, as compared with the inflammatory behaviour. No association was observed between location of the disease and MD. Conclusion Our study shows a high prevalence of MD among CD patients, which is significantly affected by disease phenotype and clinical activity. Given that the ultimate therapeutic goals for CD should include restoration of quality of life, this study shed light on the need of the inclusion of psychological assessment besides the objective measures of disease activity as an integral part of IBD care.

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