Kappa free light chains in multiple sclerosis – diagnostic accuracy and comparison with other markers

2021 ◽  
Vol 84/117 (4) ◽  
Author(s):  
Daniel Čierny ◽  
Ema Kantorová ◽  
Mária Škereňová ◽  
Egon Kurča ◽  
Ján Lehotský ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diagnostic Accuracy ◽  
Light Chains ◽  
Free Light Chains

Bence Jones proteinuria in multiple sclerosis.

1987 ◽  
Vol 33 (10) ◽  
pp. 1923-1924 ◽  
Author(s):  
A Pezzoli ◽  
E Pascali
Keyword(s):  
Multiple Sclerosis ◽  
Neurological Disorders ◽  
Healthy Subjects ◽  
Light Chains ◽  
Free Light Chains ◽  
Agarose Electrophoresis ◽  
Bence Jones Proteinuria ◽  
Bence Jones Proteins

Abstract We report our findings of Bence Jones proteins (monoclonal free light chains of immunoglobulins) in concentrated urines of patients with multiple sclerosis, by using agarose electrophoresis and immunofixation. The lack of such findings in urines from healthy subjects and patients with other neurological disorders should stimulate further investigation.

scholarly journals Free Light Chains as a Novel Diagnostic Biomarker of Immune System Abnormalities in Multiple Sclerosis and HIV Infection

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Monika Gudowska-Sawczuk ◽  
Barbara Mroczko
Keyword(s):  
Multiple Sclerosis ◽  
Immune System ◽  
Hiv Infection ◽  
Light Chains ◽  
Laboratory Diagnostics ◽  
Elevated Concentration ◽  
Free Light Chains ◽  
Heavy Chains ◽  
Immune System Dysfunction ◽  
Pubmed Database

Introduction. Immunoglobulins are molecules composed of two heavy and two light chains. Light chains are produced by B lymphocytes during the synthesis of immunoglobulins, and physiologically light chains are generally produced in excess compared to heavy chains. Light chains that are not combined to heavy chains in a whole immunoglobulin are called free light chains (FLCs). B-cell abnormalities are associated with disorders leading to an abnormal concentration of free light chains. In this study, we focus on the described changes of serum and cerebrospinal fluid concentration of free light chains in inflammatory disorders: multiple sclerosis, HIV infection, and HIV-associated lymphomas. Methods. We performed broad research of the literature pertaining to our investigation via the MEDLINE/PubMed database. Results. It has been proven that FLC determination can provide rapid information about intrathecal inflammation in patients with multiple sclerosis. Moreover, literature data suggest that free light chain determination is the most interesting alternative for oligoclonal band analysis. In the present review, we also described that HIV-related immune system dysfunction is associated with an elevated concentration of serum-free light chains. Additionally, FLCs are potentially a strong and sensitive predictor of the risk of developing HIV-associated lymphomas. Conclusion. Based on these published findings, we suggest that free light chains have high diagnostic sensitivity, which probably enables application in laboratory diagnostics.

scholarly journals Diagnostic utility of kappa free light chains in multiple sclerosis

2019 ◽  
Vol 19 (4) ◽  
pp. 277-279 ◽  
Author(s):  
Batia Kaplan ◽  
Esther Ganelin-Cohen ◽  
Sizilia Golderman ◽  
Avi Livneh
Keyword(s):  
Multiple Sclerosis ◽  
Light Chains ◽  
Diagnostic Utility ◽  
Free Light Chains

Diagnostic value of immunoglobulin free light chains at the debut of multiple sclerosis

2017 ◽  
Vol 117 (2. Vyp. 2) ◽  
pp. 60 ◽  
Author(s):  
V. D. Nazarov ◽  
G. S. Makshakov ◽  
A. V. Mazing ◽  
E. A. Surkova ◽  
V. S. Krasnov ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diagnostic Value ◽  
Light Chains ◽  
Free Light Chains

Multiple sclerosis: Free light chains in cerebrospinal fluid

Neurology ◽  
1985 ◽  
Vol 35 (10) ◽  
pp. 1443-1443 ◽  
Author(s):  
R. A. Rudick ◽  
D. R. Peter ◽  
J. M. Bidlack ◽  
D. W. Knutson
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Light Chains ◽  
Free Light Chains

scholarly journals Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Gabriella Passerini ◽  
Gloria Dalla Costa ◽  
Francesca Sangalli ◽  
Lucia Moiola ◽  
Bruno Colombo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
B Cells ◽  
Inflammatory Diseases ◽  
Meta Analysis ◽  
Area Under The Curve ◽  
The Other ◽  
Oligoclonal Bands ◽  
Light Chains ◽  
Free Light Chains ◽  
A Prospective Study

Background. The presence of CSF oligoclonal bands (OBs) is an independent prognostic factor for multiple sclerosis (MS), but the difficulties in the standardization of the test and the interlaboratory variation in reporting have contributed to its limited use in the diagnosis of the disease. Standard nephelometric assays to measure free light chains (FLC) levels have been recently developed and the test may improve the detection of intrathecal B cells activity.Methods. The presence of OBs, kappa and lambda FLC levels, and standard indices of intrathecal inflammation were assessed in 100 consecutive patients, including patients with MS, clinically isolated syndromes (CIS), other inflammatory diseases of the CNS, and other noninflammatory diseases.Results. Both KFLC and LFLC correlated strongly with the presence of OCBs and with all common tests for intrathecal inflammation (p<0.001for all comparisons). KFLC and LFLC were significantly different in patients with MS and CIS compared to the other groups (p<0.001andp<0.001, resp.) and had a better diagnostic accuracy than all the other tests (area under the curve 82.3 % for KFLC index and 79.3 % for LFLC index).Conclusion. Nephelometric assays for KFLC in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate MS patients.

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