Multifocal, metaphyseal osteonecrosis of knee due to pulse steroid treatment after cessation of fingolimod treatment in a 19-week-pregnant patient

2021 ◽  
Vol 84/117 (4) ◽  
Author(s):  
Ayfer Ertekin
Keyword(s):  
Pregnant Patient ◽  
Steroid Treatment ◽  
Pulse Steroid

Avascular necrosis of the bones: an overlooked complication of pulse steroid treatment of multiple sclerosis

2006 ◽  
Vol 13 (8) ◽  
pp. 857-861 ◽  
Author(s):  
Pinar Ce ◽  
Muhtesem Gedizlioglu ◽  
Fazyl Gelal ◽  
Pinar Coban ◽  
Gulriz Ozbek
Keyword(s):  
Multiple Sclerosis ◽  
Avascular Necrosis ◽  
Steroid Treatment ◽  
Pulse Steroid

scholarly journals Steroid-Resistant Kidney Transplant Rejection: Diagnosis and Treatment

2001 ◽  
Vol 12 (suppl 1) ◽  
pp. S48-S52
Author(s):  
H. ANDREAS BOCK
Keyword(s):  
Mycophenolate Mofetil ◽  
Transplant Rejection ◽  
Steroid Treatment ◽  
Steroid Resistance ◽  
Temporary Increase ◽  
Success Rates ◽  
Steroid Resistant ◽  
First Line Therapy ◽  
Postrenal Failure ◽  
Pulse Steroid

Abstract. Decreases in transplant function may be attributable to a variety of conditions, including prerenal and postrenal failure, cyclosporin A (CsA) toxicity, polyoma nephritis, recurrent glomerulonephritis, and rejection. The diagnosis of rejection should therefore be made on the basis of a transplant biopsy of adequate size, before the initiation of any therapy. Pulse steroid treatment (three to five 0.25- to 1.0-g pulses of methylprednisolone, administered intravenously) is the usual first-line therapy and has a 60 to 70% success rate, although orally administered prednisone (0.25 g) may be just as efficacious. Even if reverted, any rejection should trigger an at least temporary increase in basal immunosuppression, consisting of an increase in CsA or tacrolimus target levels, the addition of steroids or an increase in their dosage, the addition of mycophenolate mofetil, or a switch from CsA to tacrolimus. The addition of rapamycin or its RAD derivative may fulfill the same purpose. Steroid resistance should not be assumed before the fifth day of pulse steroid treatment, although histologic features of vascular rejection may indicate the need for more aggressive treatment earlier. Steroid-resistant rejection is traditionally treated with poly- or monoclonal antilymphocytic antibodies, with success rates of 60 to 70%. Their potential benefit must be carefully balanced against the risks of infection and lymphoma. More recently, mycophenolate mofetil has been successfully used to treat steroid-resistant rejection, but only of the interstitial (cellular) type. Switching from CsA to tacrolimus for treating recurrent or antibody-resistant rejection is successful in approximately 60% of cases. Plasmapheresis and intravenously administered Ig have been used in some desperate cases, with surprising success. Because none of the available drugs has a significantly better profile of therapeutic versus adverse effects, the possible benefits of continued rejection therapy must be continuously balanced with the potential for serious, sometimes fatal, side effects.

The Management of the Isosensitized Pregnant Patient and Her Erythroblastotic Infant

1951 ◽  
Vol 35 (3) ◽  
pp. 749-770 ◽  
Author(s):  
Alexander S. Wiener ◽  
Irving B. Wexler ◽  
Theodore H. Grundfast
Keyword(s):  
Pregnant Patient

Pregnancy & Oral Health and Dental Management in Pregnant Patient

2020 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Vishal Thakur ◽  
Dr. Reetika Thakur ◽  
Dr. Manpreet Kaur ◽  
Dr. Jasleen Kaur ◽  
Dr. Atul Kumar ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Oral Health ◽  
Human Body ◽  
Oral Hygiene ◽  
Pregnancy Outcomes ◽  
Oral Care ◽  
Pregnant Patient ◽  
Dental Management ◽  
Exciting Time

Pregnancy is a unique, exciting time in a woman's life, and there are so many changes going on in human body during pregnancy and mouth is no exception , so good oral hygiene is extremely important during pregnancy . Usually oral health is often the most neglected form of health during all stages of life & the most important cause for this neglection is lack of awareness among people & this problems also increases when a lady is pregnant because of mis-perceptions and mis-leading information in the society or due to lack of knowledge. But the fact is during pregnancy many complex physiologic changes occur in the women’s body, which can adversely affect oral health and in turn those oral health problems may lead to pregnancy outcomes like preterm birth or low birth weight. Proper oral care is of utmost importance during pregnancy to avoid these complications. Avoiding foods that may cause oral problems, proper brushing and flossing and having dental consultations on a regular basis are steps to ensure good oral health during pregnancy.

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