scholarly journals Arsenicosis Presenting with Cutaneous Squamous Cell Carcinoma: A Case Report

2019 ◽  
Vol 53 (2) ◽  
Author(s):  
Marie Len A. Camaclang ◽  
Eileen Liesl A. Cubillan ◽  
Claudine Yap-Silva
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Arsenic Exposure ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Source Control ◽  
Arsenic Level ◽  
Chronic Arsenic Exposure ◽  
History Of ◽  
Control And Management

A 29-year-old male with eleven-year history of hyperkeratotic papules and speckled pigmentation developed cutaneous squamous cell carcinoma. Arsenicosis was confirmed by elevated hair arsenic level, and histopathologic findings of arsenical keratosis and one lesion showing carcinoma-in-situ. Chronic arsenic exposure has been found to activate inflammatory and carcinogenic pathways leading to development of pre-malignant and malignant lesions. A multi-disciplinary approach involving healthcare specialists and environmentalists is crucial in source control and management of long-term complications.

Metastasis of cutaneous squamous cell carcinoma to the stomach: a rare entity

2020 ◽  
Vol 13 (11) ◽  
pp. e238731
Author(s):  
Marica Reise-Filteau ◽  
Michael Carter ◽  
Ryan DeCoste ◽  
Ali Kohansal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Functional Decline ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Rare Entity ◽  
Gastric Tumour ◽  
Comprehensive Genomic Profiling ◽  
History Of ◽  
The Right

Metastatic spread of cutaneous squamous cell carcinoma (cSCC) to the gastrointestinal tract is a rare entity. A 63-year-old woman with a history of poorly controlled HIV and a recurrent cSCC on the right temple presented with functional decline, ascites and shortness of breath. A CT scan showed widespread metastatic malignancy involving lung, pleura, heart, stomach, liver, retroperitoneum and soft-tissue. In the case presented here, an upper endoscopy revealed a submucosal lesion in the stomach. Biopsies described the lesion as a poorly differentiated SCC. Comprehensive genomic profiling yielded striking molecular similarities between the gastric tumour and the patient’s prior cSCC. It confirmed the origin of the disease and excluded spread from an occult primary. This case adds to the limited literature on gastrointestinal metastases of cSCC and serves as a reminder that non-AIDS-defining cancers are on the rise in the HIV-population.

Skin Cancer Knowledge and Preventive Behaviors among Patients with a Recent History of Cutaneous Squamous Cell Carcinoma

Dermatology ◽  
2008 ◽  
Vol 217 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Cristina Renzi ◽  
Simona Mastroeni ◽  
Thomas J. Mannooranparampil ◽  
Francesca Passarelli ◽  
Alessio Caggiati ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Recent History ◽  
Cancer Knowledge ◽  
Preventive Behaviors ◽  
History Of

scholarly journals Mortality in cancer patients with a history of cutaneous squamous cell carcinoma - a nationwide population-based cohort study

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Sigrun Alba Johannesdottir ◽  
Timothy L Lash ◽  
Annette Østergaard Jensen ◽  
Dóra Körmendiné Farkas ◽  
Anne Braae Olesen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cohort Study ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Population Based ◽  
Cutaneous Squamous Cell Carcinoma ◽  
History Of

scholarly journals Case Report: Cetuximab use in advanced cutaneous squamous cell carcinoma resistant to chemotherapy

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 933
Author(s):  
Alvise Sernicola ◽  
Salvatore Lampitelli ◽  
Sara Grassi ◽  
Antonio Giovanni Richetta ◽  
Stefano Calvieri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Whole Body ◽  
Whole Body Ct ◽  
Progression Of Disease ◽  
History Of ◽  
Epidermal Growth

We present the case of a 60-year-old man with unresectable cutaneous squamous cell carcinoma (cSCC) of the sternal area, which was not amenable to radiation therapy. The treatment history of this patient is remarkable as the disease had progressed through all lines of conventional therapy established in the literature. We decided to initiate treatment with epidermal growth factor receptor (EGFR) inhibitor cetuximab and we reassessed the patient after 12 weeks with a whole-body CT scan, documenting stability in the size and radiologic features of the disease. Cetuximab, like all current treatments for advanced cSCC, is administered off-label and proved effective in preventing further progression of disease in our patient.

scholarly journals Presence of Human Papillomavirus DNA in Plucked Eyebrow Hairs Is Associated with a History of Cutaneous Squamous Cell Carcinoma

2003 ◽  
Vol 121 (6) ◽  
pp. 1531-1535 ◽  
Author(s):  
Linda Struijk ◽  
Jan Nico Bouwes Bavinck ◽  
Patrick Wanningen ◽  
Els Van der meijden ◽  
Rudi G.J. Westendorp ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
History Of ◽  
Papillomavirus Dna

Advanced Cutaneous Squamous Cell Carcinoma Is Associated with Suboptimal Initial Management in a Cohort of 109 Patients

Dermatology ◽  
2019 ◽  
Vol 235 (6) ◽  
pp. 516-521
Author(s):  
Florian Deilhes ◽  
Serge Boulinguez ◽  
Cécile Pagès ◽  
Carle Paul ◽  
Nicolas Meyer
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rural Areas ◽  
Cognitive Disorders ◽  
Routine Care ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Good General Condition ◽  
History Of ◽  
Epidemiological Characteristics

Background: Little is known about the epidemiological characteristics of patients with advanced cutaneous squamous cell carcinoma (A-cSCC). Objective and Method: A retrospective study was conducted on a routine care cohort of 109 patients to identify the epidemiological factors associated with A-cSCC. Results: The median age was 83 years (IQR: 73.9–89.8), and the median ECOG was 1 (IQR: 1–2). Sixty percent of the patients had a history of cardiac disease and 22% had cognitive disorders. Seventy-four percent of patients were from rural/semi-rural areas (towns of <15,000 residents) and 17% were living in nursing homes. The cSCC lesions were on the head and neck in 72% of cases. Thirty-seven percent of patients were not diagnosed until the disease was in an advanced stage, indicating a lack of cSCC identification. In the remaining 69 patients, 7% did not received treatment within 3 months of the cSCC being identified, 62% had an incomplete histological report, and 37% had incomplete treatment. Conclusion: A-cSCC is associated with incomplete initial treatment in an elderly and rural population with good general condition. We hypothesize that a lack of access to good dermatological expertise may have led to underestimation of the aggressiveness of cSCC and/or therapeutic mismanagement.

scholarly journals Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Eric Jorgenson ◽  
Hélène Choquet ◽  
Jie Yin ◽  
Thomas J. Hoffmann ◽  
Yambazi Banda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Skin Pigmentation ◽  
Sun Exposure ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Genetic Ancestry ◽  
European Ancestry ◽  
History Of ◽  
Hispanic Latinos

AbstractAlthough cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in individuals of European ancestry, the incidence of cSCC in Hispanic/Latinos is also increasing. cSCC has both a genetic and environmental etiology. Here, we examine the role of genetic ancestry, skin pigmentation, and sun exposure in Hispanic/Latinos and non-Hispanic whites on cSCC risk. We observe an increased cSCC risk with greater European ancestry (P = 1.27 × 10−42) within Hispanic/Latinos and with greater northern (P = 2.38 × 10−65) and western (P = 2.28 × 10−49) European ancestry within non-Hispanic whites. These associations are significantly, but not completely, attenuated after considering skin pigmentation-associated loci, history of actinic keratosis, and sun-protected versus sun-exposed anatomical sites. We also report an association of the well-known pigment variant Ala111Thr (rs1426654) at SLC24A5 with cSCC in Hispanic/Latinos. These findings demonstrate a strong correlation of northwestern European genetic ancestry with cSCC risk in both Hispanic/Latinos and non-Hispanic whites, largely but not entirely mediated through its impact on skin pigmentation.

Sign in / Sign up

Export Citation Format

Share Document