scholarly journals Collision Tumors of the Cervix – A Case Series: Its Clinical Significance in the Management of an Early Stage Disease

2018 ◽  
Vol 52 (6) ◽  
Author(s):  
Jimmy A. Billod ◽  
Efren J. Domingo
Keyword(s):  
Cervical Cancer ◽  
Recent Literature ◽  
Early Stage ◽  
Case Series ◽  
Response To Treatment ◽  
Clinicopathologic Features ◽  
Early Stage Disease ◽  
Collision Tumors ◽  
Stage Disease ◽  
Histologic Types

Majority of cervical cancer are squamous cell carcinoma and adenocarcinoma. The co-existence of two histologic types is rare. This article presents three cases of collision tumors of the cervix within a 10-year review. All underwent radical hysterectomy for an early stage disease. Likewise, it aims to review clinicopathologic features, management, response to treatment and prognosis of these types of tumor in the light of recent literature.

The Use of Cisplatin to Treat Advanced-Stage Cervical Cancer During Pregnancy Allows Fetal Development and Prevents Cancer Progression: Report of a Case and Review of the Literature

2009 ◽  
Vol 19 (2) ◽  
pp. 273-276 ◽  
Author(s):  
Angela Boyd ◽  
Valerie Cowie ◽  
Charlie Gourley
Keyword(s):  
Cervical Cancer ◽  
Cancer Progression ◽  
Cervical Carcinoma ◽  
Fetal Development ◽  
Clear Cell ◽  
Advanced Disease ◽  
Early Stage ◽  
Third Trimester ◽  
Early Stage Disease ◽  
Stage Disease

Background:Cervical cancer is one of the most frequently encountered malignancies in pregnancy. For early-stage disease arising in late second/third trimester, treatment may be delayed until delivery. However, in advanced disease, data are lacking.Case:A 26-year-old woman presented at 21 weeks gestation with a stage IIB high-grade clear cell cervical carcinoma. At 25 + 1 weeks gestation, cisplatin 100 mg/m2 every 21 days was commenced. One month after cycle 3, a healthy infant was delivered. Thereafter, further cisplatin, intracavity cesium, and chemoradiation were administered. Findings from subsequent clinical examination and magnetic resonance imaging were normal. Fifteen months post treatment, both patient and baby remain well.Conclusion:Neoadjuvant cisplatin chemotherapy can be used in stage IIB cervical carcinoma during pregnancy to allow fetal development and prevent disease progression before delivery.

scholarly journals 18F-FDG PET/MRI in adult sarcomas

2020 ◽  
Vol 8 (6) ◽  
pp. 405-412
Author(s):  
Gianluca Cassarino ◽  
Laura Evangelista ◽  
Chiara Giraudo ◽  
Alfio Capizzi ◽  
Giovanni Carretta ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Fdg Pet ◽  
Early Stage ◽  
Soft Tissue Sarcomas ◽  
Emission Tomography ◽  
Response To Treatment ◽  
Early Stage Disease ◽  
Positron Emission ◽  
Stage Disease ◽  
18F Fdg

Abstract Aim This mini-review aims to summarize the main findings on PET/MRI in patients with sarcomas. Materials and methods A literature search was carried out on MEDLINE databases, such as PubMed, Scopus, Web of Science and Google Scholar, using the search terms “PET”, “positron emission tomography”, “PET/MRI”, “positron emission tomography/magnetic resonance imaging”, and “sarcoma”. No restrictions (i.e. language, age, type of manuscript, or the like) were applied to the search strategy. Abstracts, reviews, letters to editors, and editorials were excluded. Results Eight studies were ultimately included. From 2013 to 2019, a total of 154 adult patients with sarcomas underwent 18F-fluorodeoxyglucose (18F-FDG) PET/MRI. Of these patients, 129 had soft tissue sarcomas (STS), 5 had bone sarcomas, and 20 had cardiac masses. Thirty-two patients had PET/MRI for early-stage disease, 45 for recurrences, and 57 for the assessment of response to treatment. For staging purposes, the studies suggest that PET/MRI can significantly improve the delineation of surgical margins. At restaging, PET/MRI can also detect sarcoma recurrences more accurately than conventional imaging. Conclusions 18F-FDG PET/MRI has promising indications in patients with sarcomas, from disease staging to the assessment of response to treatment. Further studies are warranted to confirm these results, especially in subgroups with specific histopathological features.

Preoperative staging of cervical cancer: Is 18-FDG-PET/CT really effective in patients with early stage disease?

2011 ◽  
Vol 123 (2) ◽  
pp. 236-240 ◽  
Author(s):  
Mauro Signorelli ◽  
Luca Guerra ◽  
Luca Montanelli ◽  
Cinzia Crivellaro ◽  
Alessandro Buda ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Fdg Pet ◽  
Early Stage ◽  
Preoperative Staging ◽  
Early Stage Disease ◽  
Stage Disease ◽  
Pet Ct ◽  
Fdg Pet Ct

Management of Melanoma during Pregnancy: A Case Series of 11 Women Treated at NYU Langone Health

Oncology ◽  
2020 ◽  
Vol 98 (12) ◽  
pp. 847-852
Author(s):  
Amelia E. Sawyers ◽  
Anna C. Pavlick ◽  
Jeffrey S. Weber ◽  
Iman Osman ◽  
Jennifer A. Stein
Keyword(s):  
Early Stage ◽  
Case Series ◽  
Advanced Stage ◽  
Early Stage Disease ◽  
Melanoma Diagnosis ◽  
Stage Disease ◽  
Treatment Plans ◽  
Melanoma Patients ◽  
The Impact

<b><i>Objectives:</i></b> Melanoma is one of the most common malignancies diagnosed during pregnancy. This study examined the impact of pregnancy on management decisions of melanoma patients treated at NYU Langone Health (NYULH). <b><i>Methods:</i></b> We analyzed data for patients who were pregnant at initial or recurrent melanoma diagnosis at NYULH from 2012 to 2019 with prospective protocol-driven follow-up. <b><i>Results:</i></b> Of the 900 female patients accrued during this period, 11 women in the childbearing range were pregnant at melanoma diagnosis. Six patients presented with early (stage 0 or I) disease and five with advanced (stage III or IV) melanoma. Women with early stage disease had normal deliveries and minimal changes to their treatment timeline and regimen. However, patients with more advanced stage disease opted for either termination of the pregnancy or early delivery and altered treatment timelines because of pregnancy. <b><i>Conclusion:</i></b> Both melanoma stage and gestational age at diagnosis contribute to the differences in the therapeutic management of melanoma in pregnant women. Given the complexity and variety of each case of melanoma during pregnancy, informed discussion between patients and physicians allows for individualized treatment plans that address each patient’s unique situation.

French Recommendations on the Management of Invasive Cervical Cancer During Pregnancy

2009 ◽  
Vol 19 (9) ◽  
pp. 1638-1641 ◽  
Author(s):  
Philippe Morice ◽  
Febrice Narducci ◽  
Patrice Mathevet ◽  
Henri Marret ◽  
Emile Darai ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Working Group ◽  
Early Stage ◽  
Gynecologic Oncology ◽  
Invasive Cervical Cancer ◽  
Pelvic Surgery ◽  
Early Stage Disease ◽  
Stage Disease ◽  
Fetal Maturity ◽  
Set Up

Background:Cervical cancer is one of the most frequently diagnosed cancers during pregnancy, but the management of such cases remains unclear. A Working Group was set up in 2007 in France to propose national recommendations for the management of pregnant patients with invasive cervical carcinoma.Methods:The recommendations are based on this literature review conducted by the members of the Working Group.Results:Management of cervical cancer during pregnancy depends on 5 factors: stage of the disease (and the tumor size), nodal status, histological subtype of the tumor, term of the pregnancy, and whether the patient wishes to continue her pregnancy. In patients with early-stage disease diagnosed during the first 2 trimesters of pregnancy, there is an increasing tendency to preserve the pregnancy while awaiting fetal maturity in patients with absence of nodal involvement. The delivery (when the fetal maturity is attained) should be then performed using a cesarean section.Conclusions:This article proposes recommendations for the management of pregnant patients with invasive cervical cancer. These recommendations have been validated by the 3 main scientific societies of gynecologic oncology, pelvic surgery, and obstetrics and gynecology in France.

scholarly journals Nonsurgical Management of Cervical Cancer: Locally Advanced, Recurrent, and Metastatic Disease, Survivorship, and Beyond

2015 ◽  
pp. e299-e309 ◽  
Author(s):  
Helen J. Mackay ◽  
Lari Wenzel ◽  
Linda Mileshkin
Keyword(s):  
Cervical Cancer ◽  
Early Stage ◽  
Locally Advanced ◽  
Therapeutic Interventions ◽  
Early Stage Disease ◽  
Screening Programs ◽  
Nonsurgical Management ◽  
Stage Disease

Despite the declining incidence of cervical cancer as a result of the introduction of screening programs, globally it remains a leading cause of cancer-related death in women. Outcomes for patients who are diagnosed with anything but early-stage disease remain poor. Here we examine emerging strategies to improve the treatment of locally advanced disease. We discuss emerging biologic data, which are informing our investigation of new therapeutic interventions in persistent, recurrent, and metastatic cervical cancer. We recognize the importance of interventions to improve quality of life and to prevent long-term sequelae in women undergoing treatment. Finally, and perhaps most importantly, we recognize the need for global collaboration and advocacy to improve the outcome for all women at risk of and diagnosed with this disease.

Novel approaches to improve prostate cancer diagnosis and management in early-stage disease

2012 ◽  
Vol 109 ◽  
pp. 1-7 ◽  
Author(s):  
Michael Marberger ◽  
Jelle Barentsz ◽  
Mark Emberton ◽  
Jonas Hugosson ◽  
Stacy Loeb ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Diagnosis ◽  
Early Stage ◽  
Early Stage Disease ◽  
Prostate Cancer Diagnosis ◽  
Diagnosis And Management ◽  
Stage Disease ◽  
Novel Approaches ◽  
Improve Prostate Cancer
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