scholarly journals The Distribution of Activating Transcription Factor 6 (ATF6) and Nerve Growth Factor (NGF) in the Duodenum Tissue of Diabetic and Non-Diabetic Rats

2021 ◽  
Author(s):  
Şükran ARAS ◽  
Ebru KARADAĞ SARI ◽  
Serpil DAĞ
Keyword(s):  
Transcription Factor ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Rats ◽  
Nerve Growth ◽  
Activating Transcription Factor

scholarly journals Axonal Transport of Activating Transcription Factor-2 Is Modulated by Nerve Growth Factor in Nociceptive Neurons

1999 ◽  
Vol 19 (18) ◽  
pp. RC24-RC24 ◽  
Author(s):  
Jean-Dominique Delcroix ◽  
Sharon Averill ◽  
Karin Fernandes ◽  
David R. Tomlinson ◽  
John V. Priestley ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Axonal Transport ◽  
Nerve Growth ◽  
Nociceptive Neurons ◽  
Activating Transcription Factor

Ghrelin ameliorates nerve growth factor Dysmetabolism and inflammation in STZ-induced diabetic rats

2017 ◽  
Vol 32 (3) ◽  
pp. 903-912 ◽  
Author(s):  
Yuxing Zhao ◽  
Zhaoxing Shen ◽  
Dongling Zhang ◽  
Huiqiong Luo ◽  
Jinliang Chen ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Rats ◽  
Nerve Growth

Exogenous Nerve Growth Factor Promotes the Repair of Cardiac Sympathetic Heterogeneity and Electrophysiological Instability in Diabetic Rats

Cardiology ◽  
2013 ◽  
Vol 127 (3) ◽  
pp. 155-163 ◽  
Author(s):  
Mei Xue ◽  
Yong-Li Xuan ◽  
Ye Wang ◽  
He-Sheng Hu ◽  
Xiao-Lu Li ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Rats ◽  
Nerve Growth

scholarly journals Correction to: Ghrelin ameliorates nerve growth factor Dysmetabolism and inflammation in STZ-induced diabetic rats

2020 ◽  
Vol 35 (8) ◽  
pp. 1431-1432
Author(s):  
Yuxing Zhao ◽  
Zhaoxing Shen ◽  
Dongling Zhang ◽  
Huiqiong Luo ◽  
Jinliang Chen ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Rats ◽  
Nerve Growth

scholarly journals Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells.

1994 ◽  
Vol 5 (11) ◽  
pp. 1225-1241 ◽  
Author(s):  
K J Buchkovich ◽  
E B Ziff
Keyword(s):  
Transcription Factor ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Cycle Progression ◽  
Negative Regulator ◽  
Regulatory Subunit ◽  
Nerve Growth ◽  
Cyclin Dependent Kinases ◽  
Cell Cycling ◽  
Pc12 Differentiation

In the absence of serum, nerve growth factor (NGF) promotes the survival and differentiation of the PC12 pheochromocytoma cell line. In the presence of serum, NGF acts primarily as a differentiation factor and negative regulator of cell cycling. To investigate NGF control of cell cycling, we have analyzed the regulation of cyclin dependent kinases during PC12 cell differentiation. NGF treatment leads to a reduction in the steady-state protein levels of p33cdk2 and p34cdc2, two key regulators of cell cycle progression. The decrease in p33cdk2 and p34cdc2 coincides with a decrease in the enzymatic activity of cyclinA-p34cdc2, cyclinB-p34cdc2, cyclinE-p33cdk2, and cyclinA-p33cdk2 kinases. The decline in p33cdk2 and p34cdc2 kinase activity in response to NGF is accelerated in cells that over-express the p140trk NGF receptor, suggesting that the timing of the down- regulation is dependent on the level of p140trk and the strength of the NGF signal. The level of cyclin A, a regulatory subunit of p33cdk2 and p34cdc2, is relatively constant during PC12 differentiation. Nevertheless, the DNA binding activity of the cyclinA-associated transcription factor E2F/DP decreases. Thus, NGF down-regulates the activity of cyclin dependent kinases and cyclin-transcription factor complexes during PC12 differentiation.

scholarly journals Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation

1998 ◽  
Vol 18 (4) ◽  
pp. 1946-1955 ◽  
Author(s):  
Jun Xing ◽  
Jon M. Kornhauser ◽  
Zhengui Xia ◽  
Elizabeth A. Thiele ◽  
Michael E. Greenberg
Keyword(s):  
Transcription Factor ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Nerve Growth ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Ribosomal S6 Kinase

ABSTRACT The mechanisms by which growth factor-induced signals are propagated to the nucleus, leading to the activation of the transcription factor CREB, have been characterized. Nerve growth factor (NGF) was found to activate multiple signaling pathways that mediate the phosphorylation of CREB at the critical regulatory site, serine 133 (Ser-133). NGF activates the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases (MAPKs), which in turn activate the pp90 ribosomal S6 kinase (RSK) family of Ser/Thr kinases, all three members of which were found to catalyze CREB Ser-133 phosphorylation in vitro and in vivo. In addition to the ERK/RSK pathway, we found that NGF activated the p38 MAPK and its downstream effector, MAPK-activated protein kinase 2 (MAPKAP kinase 2), resulting in phosphorylation of CREB at Ser-133. Inhibition of either the ERK/RSK or the p38/MAPKAP kinase 2 pathway only partially blocked NGF-induced CREB Ser-133 phosphorylation, suggesting that either pathway alone is sufficient for coupling the NGF signal to CREB activation. However, inhibition of both the ERK/RSK and the p38/MAPKAP kinase 2 pathways completely abolished NGF-induced CREB Ser-133 phosphorylation. These findings indicate that NGF activates two distinct MAPK pathways, both of which contribute to the phosphorylation of the transcription factor CREB and the activation of immediate-early genes.

scholarly journals Spatial Distribution of Nociceptive Neuropeptide and Nerve Growth Factor Depletion in Experimental Diabetic Peripheral Nervous System

2002 ◽  
Vol 30 (5) ◽  
pp. 512-519 ◽  
Author(s):  
H Kanbayashi ◽  
H Itoh ◽  
T Kashiwaya ◽  
K Atoh ◽  
I Makino
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Substance P ◽  
Dorsal Root ◽  
Time Course ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dependent Manner ◽  
Nerve Growth

This study investigated the time-course of the nociceptive neuropeptide substance P and nerve growth factor (NGF), which facilitates substance P production, in lumbar and cervical dorsal root ganglia (DRG) of streptozotocin-induced diabetic rats. Levels of substance P and NGF were measured by radioimmunoassay and sandwich enzyme-linked immunosorbent assay, respectively, 2 months, 4 months and 8 months after induction of diabetes, and compared with age-matched non-diabetic control rats. At 2 months and 4 months, substance P and NGF levels were lower in the lumbar DRG of the diabetic rats than in controls. At 8 months, substance P and NGF were lower in both the lumbar and cervical DRG of the diabetic rats than in controls. These data demonstrate that a decrease in substance P levels in primary sensory neurons with NGF depletion occurs in an axonal length-dependent manner in diabetic rats, and that this decrease may be correlated with the duration of diabetes.

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