scholarly journals Kompres hangat jahe pada pasien asam urat: Kegiatan Pengabdian kepada masyarakat di Endang Rejo Kecamatan Seputih Agung Lampung Tengah

2020 ◽  
Vol 1 (2) ◽  
pp. 81-87
Author(s):  
Rika Yulendasari ◽  
Jemy Sundoro ◽  
Usastiawaty Cik Ayu Saadiah Isnainy
Keyword(s):  
Joint Pain ◽  
Healing Process ◽  
Joint Damage ◽  
Nutritional Therapy ◽  
Joint Disease ◽  
Herbal Therapy ◽  
Nonpharmacological Therapy ◽  
Therapy Treatment

Abstrak. Pada tahun 2018, prevalensi penyakit sendi di Lampung berada pada urutan ke-12 di Indonesia yaitu sebesar 7,2 persen. Terapi nonfarmakologi untuk mempercepat proses penyembuhan pada pasien hiperurisemia yaitu terapi herbal, hemeopati, akupuntur, akupresur, terapi nutrisi, refleksologi, terapi garam, dan yoga. Salah satunya terapi herbal, Pengobatan dilakukan secara dini agar tidak terjadi kerusakan sendi ataupun komplikasi lain, pengobatan asam urat bertujuan menghilangkan  keluhan  nyeri  sendi  dan peradangan dengan obat-obat yaitu pemberian kompres hangat jahe. Tujuan setelah penyuluhan dan demonstrasi, diharapkan pemberian kompres hangat jahe dapat untuk menurunkan rasa nyeri pada pasien Asam urat. Adapun kegiatan yang dilakukan berupa penyuluhan menggunakan leaflet dan demonstrasi kompres hangat jahe. Terdapat penurunan nyeri pada pasien asam urat setelah pemberian kompres hangat jahe selama 3 hari di Kecamatan seputih agung Desa Endang Rejo, Lampung Tengah. Dengan demikian, pemberian kompres hangat jahe pada pasien asam urat sangat efektif dalam menurunkan nyeri. Abstract: In 2018, the prevalence of the joint disease in Lampung ranks 12th at Indonesia (7.2 percent). Nonpharmacological therapy to accelerate the healing process in hyperuricemia patients, namely herbal therapy, homeopathy, acupuncture, acupressure, nutritional therapy, reflexology, salt therapy, and yoga. One of them is herbal therapy, treatment is done early so that no joint damage or other complications occur, gout treatment aims to eliminate complaints of joint pain and inflammation with drugs that are giving warm compresses of ginger. The purpose after counseling and demonstration, it is expected that the provision of warm ginger compresses can reduce pain in gout patients. The activities carried out in the form of counseling using leaflets and demonstrations of warm compresses of ginger. There was a decrease in pain in gout patients after giving warm ginger compresses for 3 days at seputih agung Endang Rejo, Central Lampung. Thus, the administration of warm ginger in patients with gout is very effective in reducing pain.

scholarly journals Pemberian Akupresur Untuk Menurunkan Nyeri Dan Kadar Asam Urat Pada Klien Asam Urat Di Poncowarno Kecamatan Kalirejo Lampung Tengah

2021 ◽  
Vol 4 (3) ◽  
pp. 515-519
Author(s):  
Teguh Pribadi ◽  
Ainur Rahma ◽  
Rika Yulendasari
Keyword(s):  
Uric Acid ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Healing Process ◽  
Nutritional Therapy ◽  
Joint Disease ◽  
Herbal Therapy ◽  
Keywords Pain ◽  
Nonpharmacological Therapy

ABSTRAKPada tahun 2018, prevalensi penyakit sendi di Lampung berada pada urutan ke-12 di Indonesia yaitu sebesar 7,2%. Terapi nonfarmakologi untuk mempercepat proses penyembuhan pada pasien hiperurisemia yaitu terapi herbal, hemeopati, akupuntur, akupresur, terapi nutrisi, refleksologi, terapi garam, dan yoga. Akupresur merupakan salah satu teknik pengobatan tradisional Cina ang dapat digunakan untuk menurunkan nyeri, mengobati penyakit dan cidera. Tujuan setelah penyuluhan dan demonstrasi, diharapkan pemberian akupresur dapat untuk menurunkan kadar asam urat dan rasa nyeri pada klien Asam urat tinggi. Adapun kegiatan yang dilakukan berupa penyuluhan menggunakan leaflet dan demonstrasi akupresur. Terdapat penurunan kadar asam urat dan nyeri pada klien asam urat tinggi setelah pemberian akupresur selama 7 hari di Poncowarno Kecamatan Kalirejo, Lampung Tengah. Dengan demikian, pemberian akupresur pada klien asam urat sangat efektif dalam menurunkan kadar asam urat dan nyeri. Kata Kunci: Nyeri, Akupresur, Asam Urat ABSTRACTIn 2018, the prevalence of joint disease Lampung ranks 12th at Indonesia (7.2%). Nonpharmacological therapy to accelerate the healing process in hyperuricemia's patients that is herbal therapy, hemeopathy, acupuncture, acupressure, nutritional therapy, reflexology, salt therapy, and yoga. Acupressure is one of the traditional Chinese medicine techniques which can be used to reduce pain, treat illnesses and injuries. The purpose after counseling and demonstration, it is expected that the provision of acupressure can reduce uric acid levels and pain in high uric acid's client. The activities carried out in the form of counseling using leaflets and acupressure demonstrations. There was a decrease in uric acid levels and pain in high uric acid's clients after giving acupressure for 7 days at Poncowarno, Kalirejo District, Central Lampung. Thus, giving acupressure to uric acid clients is very effective in reducing uric acid levels and pain. Keywords: Pain, Acupressure, Gout

scholarly journals POS0375 CHAPERONE-MEDIATED AUTOPHAGY IS A HALLMARK OF JOINT DISEASE IN OSTEOARTHRITIC PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 418.1-418
Author(s):  
I. Lorenzo ◽  
U. Nogueira-Recalde ◽  
N. Oreiro ◽  
J. A. Pinto Tasende ◽  
M. Lotz ◽  
...  
Keyword(s):  
Lateral Meniscus ◽  
Joint Damage ◽  
Joint Disease ◽  
Expression Array ◽  
Knee Oa ◽  
Human Knee Joint ◽  
Gene And Protein Expression ◽  
Functional Consequences ◽  
Chaperone Mediated Autophagy ◽  
Grade Iii

Background:In Osteoarthritis (OA), defects in macroautophagy (autophagy) are evident and precede joint damage. Indeed, pharmacological activation of autophagy protects against joint damage.Objectives:Therefore, identifying hallmarks associated with specific autophagy subtypes could shed light to fundamental mechanisms of joint disease.Methods:A comparative analysis of 35 autophagy genes was performed from blood from the Prospective OA Cohort of A Coruña (PROCOAC). Non-OA subjects (Age:61,44±1,16 years; BMI:25,25±0,52; Females, n=18) and Knee OA subjects (Age:65,50±1,05 years; BMI:29,55±0,67; Females, n=18, OA grade III-IV) were profiled using an autophagy gene expression array by SYBR green qPCR. Confirmatory studies were performed in blood from Non-OA subjects (Age:60,13±1,12 years; BMI:24,85±0,59; Females; n=30) and Knee-OA subjects (Age:68,4±1,11 years; BMI:29,65±0,55; Females; n=30, OA grade III-IV) by Taqman qPCR. The candidate gene was evaluated in human knee joint tissues (cartilage, meniscus, ligaments, synovium) with different KL grades (Age: KL0=28,3±4,50; KL2=77±6,08; KL4=62,3±3,05, n=3) and in both spontaneous aging (2, 6, 12, 18, and 30 months old, n=3) and surgically-induced OA (10 weeks after surgery, n=4) in mice by IHC. The functional consequences were studied in T/C28a2 and primary human OA chondrocytes. Autophagy, FOXO, Chaperone-mediated autophagy (CMA), inflammation, and cellular senescence were analyzing by gene and protein expression. Moreover, oxidative stress and cell death were evaluated by FACS. The contribution of CMA to chondrocyte homeostasis was evaluated by studying the capacity of CMA to restore proteostasis upon autophagy deficiency by siATG5.Results:15 autophagy-related genes were significantly downregulated in blood from knee OA patients compared to non-OA patients. No significant upregulation was found for any studied gene, although a trend towards upregulation was found in genes involved in the mTOR pathway. Four key autophagy-related genes, including ATG16L2, ATG12, ATG4B and MAP1LC3B were found downregulated in knee OA patients. Interestingly, HSP90AA1 and HSPA8, CMA markers involved in stress response and protein folding, were downregulated. Confirmatory studies showed a significant downregulation of MAP1LC3B and HSP90AA1 in blood from knee OA patients. Remarkably, HSP90A was found reduced in femoral cartilage (medial and lateral), meniscus and ACL. Moreover, this reduction was higher in medial cartilage compared to lateral cartilage and meniscus, while in synovial membrane, HSP90A expression was found increased. This expression signature was dependent on OA grade severity. In addition, we observed a decrease of HSP90A with aging and OA in mice. The functional consequences of HSP90AA1 gene silencing are related to an increase in NFκB, MMP13, and p16 expression. Interestingly, LAMP2A, a key CMA mediator, HSPA8, MAP1LC3B and FoxO1 expression were upregulated in chondrocytes with HSP90AA1 deficiency, which might indicate an early response to maintain homeostasis. On the other hand, LAMP2A protein is decreased upon HSP90AA1 deficiency, while LC3II and p62 were increased, indicating a failure in the autophagy flux that leads to impaired lysosomal degradation.Moreover, p21, p16 and prbS6 were increased upon HSP90AA1 deficiency, besides increasing mitochondrial ROS production and apoptosis. ATG5 silencing blocks autophagy by reducing LC3II and increasing prbs6, p62, p16 and p21. Interestingly, LAMP2A and HSP90A were found increased, indicating a possible compensative activation of CMA in response to autophagy defects. These results support that HSP90A has an important role in chondrocyte homeostasis by participating in the cross-talk between CMA and autophagy.Conclusion:Taking together, we identified HSP90A, a CMA regulator, as critical in chondrocyte homeostasis. These disease mechanisms are relevant in OA and constitute hallmarks potentially useful to prevent OA progression.References:[1]Caramés B, et al. Arthritis Rheum. 2010, 2015;[2]Caramés B, et al. Ann Rheum Dis. 2012.Disclosure of Interests:None declared

scholarly journals Ethnobotanical study on some useful shrubs of Astore valley, Gilgit-Baltistan, Pakistan

2014 ◽  
Vol 43 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Ali Noor ◽  
Surayya Khatoon ◽  
Moinuddin Ahmed ◽  
Abdul Razaq
Keyword(s):  
Blood Pressure ◽  
Medicinal Plants ◽  
Bone Fracture ◽  
Joint Pain ◽  
Remote Area ◽  
Ethnobotanical Study ◽  
Herbal Therapy ◽  
Anthropogenic Origin ◽  
Area Use ◽  
Gilgit Baltistan

In Astore valley, 26 species of plants under 17 genera and 13 families were found to be used as folkmedicine. The study reveals that the villagers from remote area use medicinal plants for the treatment of joint pain, bone fracture, urine problem, asthma, diabetes, blood pressure and for the treatment of other common ailments. The aborigines also use traditional herbal therapy for their live stocks. Because of high destruction pressure of anthropogenic origin, Ephedra gerardiana Wallich ex C.A.Meyer, Berberis spp., Rosa foetida Herrm. and Rhododendron hypenanthum Balf. f. were found threatened. DOI: http://dx.doi.org/10.3329/bjb.v43i1.19741 Bangladesh J. Bot. 43(1): 19-25, 2014 (June)

scholarly journals Recent advances in understanding and managing psoriatic arthritis

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2670 ◽  
Author(s):  
Dafna D. Gladman
Keyword(s):  
Psoriatic Arthritis ◽  
Early Diagnosis ◽  
Clinical Laboratory ◽  
Joint Damage ◽  
Screening Tools ◽  
Therapeutic Interventions ◽  
Joint Disease ◽  
New Therapeutic Approaches ◽  
Recent Advances ◽  
And Function

This article reviews recent advances in psoriatic arthritis (PsA) over the past several years with emphasis on early diagnosis, better understanding of pathogenesis, and new therapeutic approaches. Early diagnosis is important, since people who present late do not fare as well. There are a number of clinical, laboratory, and ultrasound features that can help identify patients destined to develop PsA, and several screening tools have been developed. It is recognized that genetic and epigenetic factors, as well as T cells and cytokines, play a role in the pathogenesis of PsA, and several targets have been identified for therapeutic interventions. New therapies have been developed and tested in PsA and have been found to be highly effective for both skin and joint manifestations of the disease. The expectation is that, in the future, PsA patients will be treated early and more aggressively and that there will not be significant progression of joint damage. Moreover, with effective treatment of the skin and joint disease and management of risk factors for the comorbidities, we can expect to reduce their occurrence and further reduce the excess mortality and reduced quality of life and function in these patients.

Do Radiographic Joint Damage and Disease Activity Influence Functional Disability Through Different Mechanisms? Direct and Indirect Effects of Disease Activity in Established Rheumatoid Arthritis

2013 ◽  
Vol 40 (9) ◽  
pp. 1505-1512 ◽  
Author(s):  
Sandhya C. Nair ◽  
Johannes W.J. Bijlsma ◽  
Jacobien H. van der Werf ◽  
Maaike J. van der Veen ◽  
Suzanne P. Linn-Rasker ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Functional Disability ◽  
Functional Decline ◽  
Joint Damage ◽  
Treatment Strategies ◽  
Joint Disease ◽  
Influence Functional ◽  
Over Time ◽  
Predictive Effect

Objective.To explore the relationship between rheumatoid arthritis (RA) disease activity and functional disability over time, considering indirect (predictive) and direct (concurrent) associations as well as the influence of radiographic joint damage and treatment strategy.Methods.Functional disability [Health Assessment Questionnaire (HAQ)], disease activity [28-joint Disease Activity Score (DAS28)], and radiographic joint damage [Sharp/van der Heijde score (SHS)] were measured in 4 consecutive randomized controlled trials with increasingly intensive (tight control) treatment strategies. Average followup time for the 3 cohorts was 97, 53, and 50 months, respectively. Next to current DAS28, the previous DAS28 was used to study the predictive effect of a change in DAS28 on progression of functional disability (HAQ). Finally, it was investigated whether SHS mediated the predictive effect of DAS28.Results.In patients treated with intensive treatment strategies, the progression of HAQ over time was statistically significantly less (p < 0.0001). The predictive influence of DAS28 on HAQ progression increased over the duration of the disease. SHS was not found to influence HAQ progression and did not mediate the predictive effect of DAS28. In the less intensively treated patients, the direct effect of disease activity decreased with disease duration, and contrarily, SHS did influence HAQ progression, but was not found to (fully) mediate the predictive effect of DAS28.Conclusion.In patients with RA treated with modern treatment strategies, there is less functional decline over time. Further, disease activity does predict functional decline but joint damage does not. This might indicate that factors associated with cumulative disease activity but not visible on radiographs can influence functional decline in patients with RA. This further underlines the importance of disease activity as a treatment target in early RA and in established RA.

The effects of the Mulligan concept in ankylosing spondylitis: a report of two cases

2019 ◽  
Vol 26 (5) ◽  
pp. 1-10
Author(s):  
Songül Baglan-Yentur ◽  
Oğuzhan Mete ◽  
Zeynep Tuna ◽  
Abdurrahman Tufan ◽  
Deran Oskay
Keyword(s):  
Ankylosing Spondylitis ◽  
Mechanical Stress ◽  
Sacroiliac Joint ◽  
Joint Pain ◽  
Functional Performance ◽  
Morning Stiffness ◽  
Joint Damage ◽  
Sacroiliac Joint Pain ◽  
Before And After ◽  
Mulligan Concept

Introduction/Aims The first complaint in ankylosing spondylitis is usually sacroiliac joint pain and morning stiffness. Aside from inflammation, sacroiliac joint pain is related to joint damage and mechanical stress. Many different methods are applied in the treatment of sacroiliac joint pain. This study aimed to investigate the effects of sacroiliac joint mobilisation on pain, function and mobility in patients with ankylosing spondylitis. Methods Two patients presented with sacroiliac joint pain: a 46-year-old male and a 34-year-old female. Both patients received eight sessions of mobilisation with movement, according to the Mulligan concept (sacroiliac joint mobilisation and mechanical correction). Sessions were held at 4-day intervals over a 28-day period. The patients were assessed for sacroiliac joint mobilisation immediately before and after the first session and their pain, function and mobility were assessed at the second and eighth sessions. Findings A decrease in pain and increases in functional performance and mobility were noted in both cases at the end of eight sessions. Conclusions Sacroiliac joint mobilisation might be effective in improving pain, function and mobility in patients with ankylosing spondylitis. Further studies should be conducted with an increased number of participants to confirm these findings.

99Tcm nanocolloid scintigraphy: a reliable way to detect active joint disease in patients with peripheral joint pain

2001 ◽  
Vol 22 (3) ◽  
pp. 315-318 ◽  
Author(s):  
B. K. ADAMS ◽  
H. M. AL ATTIA ◽  
R. A. KHADIM ◽  
Z. Y. AL HAIDER
Keyword(s):  
Joint Pain ◽  
Joint Disease ◽  
Active Joint

Musculoskeletal Pathologies in Children with Haemophilia Evaluated using a Standardised Physical Joint Scoring System to Assess Disability

2011 ◽  
Vol 07 (01) ◽  
pp. 76 ◽  
Author(s):  
Sonata Saulyte Trakymiene ◽  
Keyword(s):  
Treatment Efficacy ◽  
Scoring System ◽  
Joint Damage ◽  
Joint Disease ◽  
Severe Haemophilia ◽  
International Consensus ◽  
Health Score ◽  
Haemophilic Arthropathy ◽  
Joint Health ◽  
Joint Assessment

Repeated bleeding into the joints leads to the development of chronic and progressive joint disease in 90% of people with severe haemophilia. Owing to recurrent haemarthroses, musculoskeletal outcome remains an important hallmark of treatment efficacy in haemophilia. Physical joint assessment is commonly used to measure structural and functional joint damage. With the development and introduction of prophylaxis, the most widely used instruments for the assessment of haemophilic arthropathy were found to lack sensitivity to detect the earliest signs of joint disease. To address these inadequacies, a new international consensus tool, the Haemophilia Joint Health Score (HJHS), was developed. The HJHS appears to be a sensitive, reliable and valid tool. However, the HJHS needs further evaluation in various patient populations to assess its applicability and usefulness.

scholarly journals Differential diagnosis in joint and spine damages

2020 ◽  
Vol 14 (2) ◽  
pp. 14-19
Author(s):  
N. V. Chichasova
Keyword(s):  
Differential Diagnosis ◽  
Rheumatic Diseases ◽  
Joint Pain ◽  
Joint Damage ◽  
Diagnostic Strategy ◽  
Common Variants ◽  
European League Against Rheumatism ◽  
Definition Of ◽  
European League ◽  
Key Questions

The lecture covers main approaches to differential diagnosis in rheumatic diseases. It highlights the key questions that should be answered at the primary examination of the patient. The most important signs that can identify severe, sometimes urgent nonrheumatic diseases are presented. The author describes pain of different patterns and intensity and the most common variants of acute or chronic onset of mono-, oligo-, or polyarthritis. The 2016 European League Against Rheumatism (EULAR) definition of arthralgia suspicious for the development of rheumatoid arthritis is given. The lecture presents the signs indicating the inflammatory nature of back pain in cases of suspected spondyloarthritis (SpA), as well as a two-step diagnostic strategy for axial SpA. Attention is paid to the semiotics of joint damage and extra-articular manifestations in various rheumatic diseases. A brief algorithm for a differential diagnostic search for joint pain is given.

scholarly journals Value of Examination Under Fluoroscopy for the Assessment of Sacroiliac Joint Dysfunction

2015 ◽  
Vol 5;18 (5;9) ◽  
pp. E781-E786
Author(s):  
Burton D Beakley
Keyword(s):  
Sensitivity And Specificity ◽  
Roc Curve ◽  
Predictive Value ◽  
Joint Pain ◽  
Clinical Symptoms ◽  
Small Sample ◽  
Joint Disease ◽  
Pain Clinic ◽  
Predictive Values ◽  
Si Joint

Background: Pain emanating from the sacroiliac (SI) joint can have variable radiation patterns. Single physical examination tests for SI joint pain are inconsistent with multiple tests increasing both sensitivity and specificity. Objective: To evaluate the use of fluoroscopy in the diagnosis of SI joint pain. Study Design: Prospective double blind comparison study Setting: Pain clinic and radiology setting in urban Veterans Administration (VA) in New Orleans, Louisiana. Methods: Twenty-two adult men, patients at a southeastern United States VA interventional pain clinic, presented with unilateral low back pain of more than 2 months’ duration. Patients with previous back surgery were excluded from the study. Each patient was given a Gapping test, Patrick (FABERE) test, and Gaenslen test. A second blinded physician placed each patient prone under fluoroscopic guidance, asking each patient to point to the most painful area. Pain was provoked by applying pressure with the heel of the palm in that area to determine the point of maximum tenderness. The area was marked with a radio-opaque object and was placed on the mark with a fluoroscopic imgage. A site within 1 cm of the SI joint was considered as a positive test. This was followed by a diagnostic injection under fluoroscopy with 1 mL 2% lidocaine. A positive result was considered as more than 2 hours of greater than 75% reduction in pain. Then, in 2-3 days this was followed by a therapeutic injection under fluoroscopy with 1 mL 0.5% bupivacaine and 40 mg methylprednisolone. Results: Each patient was reassessed after 6 weeks. The sensitivity and specificity in addition to the positive and negative predictive values were determined for both the conventional examinations, as well as the examination under fluoroscopy. Finally, a receiver operating characteristic (ROC) curve was constructed to evaluate test performance. The sensitivity and specificity of the fluoroscopic examination were 0.82 and 0.80 respectively; Positive predictive value and negative predictive value were 0.93 and 0.57 respectively. The area under ROC curve was 0.812 which is considered a “good” test; however the area under ROC for the conventional examination were between 0.52 -0.58 which is considered “poor to fail”. Limitations: Variation in anatomy of the SI joint, small sample size. Conclusions: Multiple structures of the SI joint complex can result in clinical symptoms of pain. These include intra-articular structures (degenerative arthritis, and inflammatory conditions) as well as extraarticular structures (ligaments, muscles, etc.). Key words: Sacroilliac joint disease, radicular pain, thigh thrust test, compression test, distraction test, Gaenslen test, Patrick test (FABER test)

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