scholarly journals Frequency of SARS-CoV-2 infection and characterization of the clinical course in patients with Systemic Lupus Erythematosus in the city of Manaus-Amazonas

2021 ◽  
Author(s):  
Gabriella Bacellar Marques ◽  
Lucila Cristina Tomé Garcia ◽  
Cecília Tizatto Barroso ◽  
Vitória Miki Pang Takatani ◽  
Samuel Elias Basualto Dias ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Course ◽  
Systemic Lupus ◽  
The City

Longterm Outcomes and Damage Accrual in Patients with Childhood Systemic Lupus Erythematosus with Psychosis and Severe Cognitive Dysfunction

2013 ◽  
Vol 40 (4) ◽  
pp. 513-519 ◽  
Author(s):  
Lily Siok Hoon Lim ◽  
Arlette Lefebvre ◽  
Susanne Benseler ◽  
Earl D. Silverman
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Cognitive Dysfunction ◽  
Lupus Erythematosus ◽  
Clinical Course ◽  
Immunosuppressive Treatment ◽  
Damage Index ◽  
Response To Treatment ◽  
Systemic Lupus ◽  
Damage Accrual

Objective.(1) To describe the clinical course and response to treatment; and (2) to evaluate and compare damage accrual of distinct phenotypic subgroups of patients with clinically important psychiatric illness of pediatric systemic lupus erythematosus (pSLE).Methods.A single-center cohort study of patients with pSLE followed at a pediatric lupus clinic from 1985 to July 2009. Clinical course and response to treatment were studied. Remission was defined by absence of psychiatric/cognitive symptoms while receiving minimal doses of prednisone. Disease activity and damage were measured using SLE Disease Activity Index and SLE Damage Index.Results.Fifty-three children were included: 40 with psychosis and cognitive dysfunction (PSYC group) and 13 with isolated cognitive dysfunction (COG group). All received immunosuppressive treatment. Eighteen of 32 treated with azathioprine required a change to cyclophosphamide for poor response but none on cyclophosphamide required a change. The median times to remission were 72 weeks (PSYC) and 70 weeks (COG). Eight patients (7 PSYC, 1 COG) experienced flare following response/remission. New damage was noted in 50% of children at a median of 11 months: 57% of PSYC group, 31% of COG group. Persistent cognitive dysfunction was seen in 16% of PSYC patients and 15% of COG patients.Conclusion.Most patients responded to immunosuppressive treatment, although median time to remission was > 1 year. Roughly half the patients acquired a new damage item, most of which did not interfere with functional abilities. Fewer than 20% of patients developed neuropsychiatric damage. Both phenotypes of psychiatric pSLE responded equally well to current treatment.

scholarly journals A Real-World Characterization of Patients With “Moderate-To-Severe” Systemic Lupus Erythematosus

2014 ◽  
Vol 17 (7) ◽  
pp. A522
Author(s):  
V. Strand ◽  
J. Johnson ◽  
C. Vandeloo ◽  
C. Galateanu ◽  
S. Lobosco
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Real World ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Severe Systemic Lupus Erythematosus

Characterization of C1q-binding IgG complexes in systemic lupus erythematosus

1984 ◽  
Vol 30 (1) ◽  
pp. 104-116 ◽  
Author(s):  
Shu Uwatoko ◽  
Shinichi Aotsuka ◽  
Masako Okawa ◽  
Yasuo Egusa ◽  
Ryuichi Yokohari ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Lupus Eritematosus Sistemik pada Pria

2021 ◽  
Vol 3 (2) ◽  
pp. 37-42
Author(s):  
Harry Andrean ◽  
Raveinal Raveinal
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Course ◽  
Multiple Organ ◽  
Systemic Lupus ◽  
Malar Rash ◽  
Mouth Ulcer ◽  
Pulse Dose ◽  
Aggressive Clinical Course ◽  
Complex Autoimmune Disease

Introduction: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by presence of nucleus autoantibody and affected multiple organ. Systemic lupus erythematosus is more common in women than men with ratio 2:1 to 15:1. Men with SLE often have a more aggressive clinical course, lead to a poorer prognosis compared with women with SLE. Case Report: A man, 29 years old came to hospital with main complain joint pain increased since 1 week ago, accompanied with red spot on face, trunk, hands, foot, and back, hair loss, swollen leg, mouth ulcer, and fatique. Malar rash and discoid rash were identified from physical examination. From laboratorium, ANA profile was positive for RNP/Sm, Sm, dsDNA, and histone. Skin biopsy showed a lupus discoid. Conclusion: The patient was treated with pulse-dose methylprednisolone for 3 days and showed a good response clinically.

scholarly journals Molecular Characterization of Circulating Plasma Cells in Patients with Active Systemic Lupus Erythematosus

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44362 ◽  
Author(s):  
Patricia L. Lugar ◽  
Cassandra Love ◽  
Amrie C. Grammer ◽  
Sandeep S. Dave ◽  
Peter E. Lipsky
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Molecular Characterization ◽  
Lupus Erythematosus ◽  
Plasma Cells ◽  
Active Systemic Lupus Erythematosus ◽  
Systemic Lupus
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