scholarly journals THALIDOMIDE INDUCED PERIPHERAL NEUROPATHY IN LUPUS: DRUG PLASMA LEVELS AND INCIDENCE

2021 ◽  
Author(s):  
Emily Figueiredo Neves Yuki ◽  
Renata Soares ◽  
Léonard de Vinci Kanda Kupa ◽  
Carlos Otto Heise ◽  
Nadia Emi Aikawa ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Plasma Levels ◽  
Drug Plasma ◽  
Drug Plasma Levels

Noncompliance Contributing to Apparent Drug Failure in Status Epilepticus

PEDIATRICS ◽  
1974 ◽  
Vol 53 (6) ◽  
pp. 938-940
Author(s):  
John T. Wilson
Keyword(s):  
Status Epilepticus ◽  
Plasma Levels ◽  
Seizure Activity ◽  
Drug Level ◽  
Continuous Control ◽  
Drug Plasma ◽  
Intravenous Diazepam ◽  
Grand Mal ◽  
History Of ◽  
Drug Plasma Levels

The case to be described illustrates apparent drug failure because of noncompliance in the drug delivery system, and the sequelae of this mishap. In connection with investigation of this case further occurrences of noncompliance were found. This incident also brings into focus the importance of plasma drug level determinations for effective application of therapy. CASE REPORT A 7-year-old, 26-kg, black girl was admitted with a 16-month history of nonprogressive neurologic disease accompanied by clinical and EEG evidence of petit mal and grand mal epilepsy which responded to diphenylhydantoin (DPH), phenobarbital or ethosuximide (Zarontin) treatment. Generalized convulsions had been infrequent for four months, but, before the present admission, a marked increase in grand mal seizures was noted. On the day of admission (day 1), recurrent generalized seizure activity progressed to status epilepticus within six hours. Intravenous diazepam (Valium [0.18/mg/kg]) controlled the seizures. Primidone (Mysoline), 250 mg tid, and ethosuximide, 500 mg tid were prescribed as maintenance anticonvulsants in an attempt to allay further progression to status epilepticus. For the next several days her seizures could be controlled only with paraldehyde (0.36 mg/kg intravenously), although administration of other drugs was continued. Assays of drug plasma levels did not become available until day 6. They disclosed that plasma levels of diazepam and demethyldiazepam were high (289 and 50 ng/ml, respectively) one hour after dosing with 0.18 mg/kg. This indicated that diazepam was not effective for continuous control of seizures, but this information was not acted upon immediately. The most striking finding was that primidone was not detected in plasma, although the prescibed dosage was 250 mg tid.

Transient Mood Elevation Associated with Antidepressant Drug Decrease*

1987 ◽  
Vol 32 (9) ◽  
pp. 764-767 ◽  
Author(s):  
M. Corral ◽  
K. Sivertz ◽  
B.D. Jones
Keyword(s):  
Therapeutic Effect ◽  
Case History ◽  
Plasma Levels ◽  
Antidepressant Drug ◽  
Unipolar Depression ◽  
Clinical Implications ◽  
Similar Drug ◽  
Drug Plasma ◽  
Drug Plasma Levels ◽  
Drug Relapse

The development of hypomania, mania and transient mood elevation within 2–3 days of antidepressant discontinuation, and lasting days to several weeks has been reported in unipolar depressed patients. Imipramine and desipramine are the antidepressants most frequently associated with the above phenomena. A reported case of transient mood elevation following abrupt reduction but not discontinuation of desipramine therapy in a woman with unipolar depression is described. The phenomenon was observed and documented on two separate occasions. Mood elevation occurred despite decreased plasma levels of the drug. Relapse followed despite maintenance of dose and similar drug plasma levels. Factors which could account for the transitory improvement of mood are examined. It is suggested that the patient's improvement in mood may have occurred due to a rebound paradoxical therapeutic effect. The features of the presented case history which appear to support this hypothesis are discussed. Also the clinical implications of this phenomenon are reviewed.

DRUG PLASMA LEVELS

InPharma ◽  
1980 ◽  
Vol 238 (1) ◽  
pp. 4-4
Keyword(s):  
Plasma Levels ◽  
Drug Plasma ◽  
Drug Plasma Levels
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