scholarly journals Online spread and patient contribution to the improvement of a systemic sclerosis patient education handout during the pandemic of COVID-19

2021 ◽  
Author(s):  
CAIO CARVALHAIS CHAVES ◽  
JOÃO VICTOR DE PINHO COSTA ◽  
ANDERSON RAMOS LISBOA ◽  
ANA LETICIA FONTES DE OLIVEIRA MARCELINO ◽  
URIAS PAULO FURQUIM JUNIOR ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Patient Education ◽  
Systemic Sclerosis Patient

scholarly journals New Autoantibody Specificities in Systemic Sclerosis and Very Early Systemic Sclerosis

Antibodies ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 12
Author(s):  
Roberto Lande ◽  
Raffaella Palazzo ◽  
Anna Mennella ◽  
Immacolata Pietraforte ◽  
Marius Cadar ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Early Diagnosis ◽  
Antibody Response ◽  
Allelic Variant ◽  
The Other ◽  
Autoantibody Response ◽  
Autoimmune Condition ◽  
Early Systemic Sclerosis ◽  
Systemic Sclerosis Patient

Chemokine (C-X-C motif) ligand 4 (CXCL4) is a biomarker of unfavorable prognosis in Systemic Sclerosis (SSc), a potentially severe autoimmune condition, characterized by vasculitis, fibrosis and interferon (IFN)-I-signature. We recently reported that autoantibodies to CXCL4 circulate in SSc patients and correlate with IFN-α. Here, we used shorter versions of CXCL4 and CXCL4-L1, the CXCL4 non-allelic variant, to search for autoantibodies exclusively reacting to one or the other CXCL4 form. Moreover, to address whether anti-CXCL4/CXCL4-L1 antibodies were present before SSc onset and predicted SSc-progression, we longitudinally studied two VEDOSS (Very Early Diagnosis of Systemic Sclerosis) patient cohorts, separating SSc-progressors from SSc-non-progressors. We found that anti-CXCL4-specific autoantibodies were present in both SSc and VEDOSS patients (both SSc-progressors and SSc-non-progressors). Anti-CXCL4-L1-specific autoantibodies were especially detected in long-standing SSc (lsSSc). Anti-CXCL4/CXCL4-L1 antibodies correlated with IFN-α and with specific SSc-skin features but only in lsSSc and not in early SSc (eaSSc) or VEDOSS. Thus, a broader antibody response, with reactivity spreading to CXCL4-L1, is characteristic of lsSSc. The early anti-CXCL4 autoantibody response seems qualitatively different from, and likely less pathogenic than, that observed in advanced SSc. Lastly, we confirm that anti-CXCL4 autoantibodies are SSc-biomarkers and uncover that also CXCL4-L1 becomes an autoantigen in lsSSc.

scholarly journals The first case report of fatal acute pulmonary dysfunction in a systemic sclerosis patient treated with rituximab

2016 ◽  
Vol 45 (3) ◽  
pp. 249-250 ◽  
Author(s):  
K Nakamura ◽  
A Yoshizaki ◽  
T Takahashi ◽  
R Saigusa ◽  
T Taniguchi ◽  
...  
Keyword(s):  
Case Report ◽  
Systemic Sclerosis ◽  
Pulmonary Dysfunction ◽  
First Case ◽  
Systemic Sclerosis Patient

Azathioprine-induced pure red cell aplasia in a systemic sclerosis patient with interstitial pneumonia

2010 ◽  
Vol 38 (3) ◽  
pp. 285-287 ◽  
Author(s):  
Mariko SUTO ◽  
Yayoi NAGAI ◽  
Michiko HASEGAWA ◽  
Hiroshi HANDA ◽  
Osamu ISHIKAWA
Keyword(s):  
Systemic Sclerosis ◽  
Interstitial Pneumonia ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia ◽  
Systemic Sclerosis Patient

scholarly journals High resolution gastrointestinal monitoring in a systemic sclerosis patient with gastrointestinal dysfunction

2015 ◽  
Vol 23 (35) ◽  
pp. 5739
Author(s):  
Hui Su ◽  
Guo-Jun Jiang ◽  
Kui-Liang Liu ◽  
Ming-Ming Meng ◽  
Hong Liu ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
High Resolution ◽  
Gastrointestinal Dysfunction ◽  
Systemic Sclerosis Patient

scholarly journals DIGITAL ULCERS AND MULTIPLE AMPUTATIONS IN A SYSTEMIC SCLEROSIS PATIENT

2017 ◽  
Vol 26 (4) ◽  
pp. 173-178
Author(s):  
Laura Groseanu ◽  
◽  
Ina Cambur ◽  
Andra Balanescu ◽  
Ruxandra Ionescu ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Lower Extremity ◽  
Multidisciplinary Approach ◽  
Macrovascular Disease ◽  
Lower Limbs ◽  
Digital Ulcers ◽  
Upper Limbs ◽  
Course Of Disease ◽  
Diffuse Cutaneous Systemic Sclerosis ◽  
Systemic Sclerosis Patient

We are presenting the case of a 48 years old female diagnosed at the age of 28 with diffuse cutaneous systemic sclerosis. During the course of disease, despite the vasodilatator treatments and immunosuppresion for visceral involvement, the patient developed multiple infected digital ulcers both in the upper limbs and in the lower limbs, which complicated with wet gangrene, requiring transmetatarsal amputations. At that time, a macrovascular disease or a prothrombotic condition were excluded. Patient also developed infected nondigital lower extremity ulcers, which slowly healed after Alprostadil treatment. The evolution of our patient‘s disease demonstrate that the management of scleroderma vasculopathy represent a challange and a multidisciplinary approach is needed.

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