scholarly journals Vasculitis Damage Index and C-Reactive Protein As Main Predictors Of Infection In Admitted Systemic Vasculitis Patients

2021 ◽  
Author(s):  
Luma Mendes Brito ◽  
Rodrigo da Silveira Vasconcelos ◽  
Felipe Mendonça de Santana ◽  
CARLOS EMILIO INSFRAN ECHAURI ◽  
Lorenza Rosa Silvério Scomparin ◽  
...  
Keyword(s):  
Systemic Vasculitis ◽  
Damage Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Vasculitis Damage Index

Sequential ANCA and C-reactive protein estimations in the management of systemic vasculitis

Apmis ◽  
1990 ◽  
Vol 98 (S19) ◽  
pp. 44-44 ◽  
Author(s):  
D. R. W. Jayne ◽  
A. Heaton ◽  
D. B. Evans ◽  
C. M. Lockwood
Keyword(s):  
Systemic Vasculitis ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals AB0485 INVESTIGATION OF PERMANENT ORGAN DAMAGE IN GIANT CELL ARTERITIS: DISEASE FLARES ARE ASSOCIATED WITH INCREASED DAMAGE SCORES

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1540.2-1540
Author(s):  
B. Ince ◽  
S. Artan ◽  
Y. Yalçinkaya ◽  
B. Artim-Esen ◽  
A. Gül ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Vision Loss ◽  
Systemic Vasculitis ◽  
Damage Index ◽  
Organ Damage ◽  
Cardiovascular Damage ◽  
Vasculitis Damage Index

Background:Development of organ damage is a major concern in patients with systemic vasculitis. Treatment may also contribute to this important outcome. Scoring systems has been developed to evaluate organ damage in systemic vasculitis and specifically for large vessel vasculitis (1).Objectives:We aimed to investigate permanent organ damage and determining factors in our giant cell arteritis GCA cohort.Methods:Organ damage detected at the time of diagnosis and / or follow-up and irreversible for at least 3 months in GCA patients followed up between 1998-2018 were recorded by using Vasculitis Damage Index (VDI) and Vascular Vasculitis Damage Index (LVVID) fom patient records of our vasculitis clinic. In the statistical evaluation, chi-square, students t-test and logistic regression analysis were used.Results:Eighty-nine patients (64% women, mean age 67.9 ± 9.1) included in the study, the mean follow-up duration was 61.6 ± 58.6 months. All organ damage findings according to both VDI and LVVID are shown in table-1. In this cohort, cardiovascular damage items and diabetes mellitus were prevalent at baseline. At least one damage item was present in 53 (59,5%) according to VDI; 54 (%60,7) according to LVVID and agreement was high between two damage indices (kappa=0.97). Forty-seven of patients (52%) had a damage item presumably with contribution of GC treatment e.g. locomotor system findings, hypertension, diabetes and cataract; 12 (13,5%) had damage items related to disease (total or partial vision loss, ischemic optical neuropathy). Mean time to diagnosis after initial symptoms was longer in patients with permanent vision loss (10,2±4,3 vs. 5,2±1,2 months p=0.006). The presence of damage was associated with flares in univariate and multivariate analysis (29/54 vs. 2/35 p<0,001 OR=19 %95 GA 4,2– 87,9). All patients who had a flare during the first year (n = 15) developed signs of damage at follow-up. No association was found between the development of organ damage and the age of diagnosis, the time between first complaint and diagnosis, presence of cranial, ophthalmologic findings, PET-CT positivity, cumulative steroid dose, and DMARD use.Conclusion:In our study, permanent organ damage was analysed by using diffrerent indices. In this patient population baseline cardiovascular damage and diabetes mellitus were frequent as expected but information for osteoporosis was lacking. More than half of the patients had damage and significant part of the present items was considered due to corticosteroid treatment. The most common damage item developed was osteoporosis. There was a very good agreement between the two indices, despite few specific items in LVVID. The striking relationship of disease flare with damage and frequency of visual problems despite treatment indicate the necessity of new treatment strategies.References:[1]Kermani, T.A., et al.,Evaluation of damage in giant cell arteritis.Rheumatology (Oxford), 2018.57(2): p. 322-328.Disclosure of Interests: :None declared

scholarly journals Examination of disease severity in systemic vasculitis from the novel perspective of damage using the vasculitis damage index (VDI)

Rheumatology ◽  
1998 ◽  
Vol 37 (1) ◽  
pp. 57-63 ◽  
Author(s):  
A. R. Exley ◽  
P. A. Bacon ◽  
R. A. Luqmani ◽  
G. D. Kitas ◽  
D. M. Carruthers ◽  
...  
Keyword(s):  
Disease Severity ◽  
Systemic Vasculitis ◽  
Damage Index ◽  
The Novel ◽  
Vasculitis Damage Index

scholarly journals Kawasaki disease with low C-reactive protein levels

2021 ◽  
Vol 10 (2) ◽  
pp. 241-245
Author(s):  
Toshimasa Nakada
Keyword(s):  
Kawasaki Disease ◽  
Clinical Features ◽  
Initial Treatment ◽  
Systemic Vasculitis ◽  
Ivig Therapy ◽  
C Reactive Protein ◽  
High Group ◽  
Reactive Protein ◽  
Serum Crp ◽  
Low Serum

Kawasaki disease (KD) is an acute febrile systemic vasculitis that primarily affects children, and coronary artery lesions (CALs) are severe complications. Clinical features and outcomes of patients with KD associated with low serum C-reactive protein (CRP) levels (< 3.0 mg/dL) before initial treatment remain unclear. The objective of this retrospective study was to elucidate the clinical features and outcomes of patients with KD and low serum CRP levels. Data were included from 220 patients with KD who underwent acute-phase treatment from January 2009 to February 2021 in our department. Patients were divided into low group (n = 50) and high group (n = 170) according to serum CRP levels before initial treatment. The rates of incomplete KD (48.0% vs. 10.6%, P < 0.001) and serum albumin levels (g/dL) before initial treatment (median 3.60 vs. 3.30, P < 0.001) were significantly different between the groups. The rate of patients who required intravenous immunoglobulin (IVIG) therapy was significantly lower in the low group compared to the high group (74.0% vs. 97.1%, P < 0.001). However, the rates of initial IVIG therapy resistance (10.8% vs. 25.5%, P= 0.055) and CALs (2.0% vs. 4.7%, P= 0.475) were similar between the groups. No patient in the low group experienced CALs one month after KD onset. The severity of the disease in patients with KD and low CRP levels was milder than in those with high CRP levels.

scholarly journals Systemic Lupus Erythematosus in a Multiethnic US Cohort (LUMINA): LXI. Value of C-Reactive Protein as a Marker of Disease Activity and Damage

2008 ◽  
Vol 35 (12) ◽  
pp. 2355-2358 ◽  
Author(s):  
ANAM. BERTOLI ◽  
LUIS M. VILÁ ◽  
JOHN D. REVEILLE ◽  
GRACIELA S. ALARCÓN
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Multivariable Analysis ◽  
Damage Index ◽  
C Reactive Protein ◽  
Systemic Lupus ◽  
Reactive Protein ◽  
Damage Accrual ◽  
Hs Crp

ObjectiveTo determine whether C-reactive protein (CRP) measured by a high sensitivity (hs) assay is a surrogate marker of disease activity and damage in systemic lupus erythematosus (SLE).MethodsFive hundred eighty-eight patients with SLE participating in a multiethnic cohort (Hispanic, African American, and Caucasian) were studied. Disease activity was measured with the Systemic Lupus Activity Measure-Revised (SLAM-R) and damage with the Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (SDI). hs-CRP was measured by immunometric assay. Disease activity and hs-CRP were measured at enrollment and damage accrual at last visit. The association of hs-CRP with the SLAM-R and SDI was examined by univariable (Pearson’s correlation) and multivariable (linear regression) analyses. The association of hs-CRP and each individual domain of the SLAM-R and SDI was examined by Spearman’s correlation.Resultshs-CRP was associated with the SLAM-R in the univariable (r = 0.35, p < 0.001) and multivariable (t = 7.11, coefficient β = 0.27, p < 0.001) analyses. It also correlated with the constitutional, eye, pulmonary, gastrointestinal, neuromotor, and laboratory domains of the SLAM-R. hs-CRP was associated with the SDI (r = 0.12, p = 0.004) in the univariable analysis but not in the multivariable analysis. When the individual domains of the SDI were analyzed, hs-CRP correlated with the renal, pulmonary, cardiovascular, musculoskeletal, and diabetes domains.Conclusionhs-CRP was associated with disease activity but not with overall damage accrual; however, it correlated with specific domains of the damage index. hs-CRP may be useful to monitor the course of the disease and predict its intermediate outcome, but longitudinal studies with serial hs-CRPmeasurements are necessary to define its clinical value.

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