Minibrains: A New Dimension in Organoid Research

2020 ◽  
Author(s):  
Sayani Basu
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Neurodevelopmental Disorders ◽  
Human Brain Development ◽  
The Way

Minibrain technology paves the way for future organoid research and offers a powerful potential to study human brain development and to assess neurodevelopmental disorders.

scholarly journals Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders

Physiology ◽  
2019 ◽  
Vol 34 (5) ◽  
pp. 365-375 ◽  
Author(s):  
Jason W. Adams ◽  
Fernanda R. Cugola ◽  
Alysson R. Muotri
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Neurodevelopmental Disorders ◽  
Technological Advancement ◽  
Neurodevelopmental Disease ◽  
Human Brain Development ◽  
Therapeutic Development ◽  
Innovative Tool

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development, thus offering an innovative tool by which to model human neurodevelopmental disease. We review here how brain organoids have been used to study neurodevelopmental disease and consider their potential for both technological advancement and therapeutic development.

scholarly journals §Using organoids to study human brain development and evolution

2021 ◽  
Author(s):  
Wai‐Kit Chan ◽  
Rana Fetit ◽  
Rosie Griffiths ◽  
Helen Marshall ◽  
John O Mason ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Human Brain Development ◽  
Development And Evolution

scholarly journals Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia

2021 ◽  
Author(s):  
Ugomma C. Eze ◽  
Aparna Bhaduri ◽  
Maximilian Haeussler ◽  
Tomasz J. Nowakowski ◽  
Arnold R. Kriegstein
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Single Cell ◽  
Radial Glia ◽  
Cortical Development ◽  
Cell Types ◽  
Human Cortex ◽  
Early Stages ◽  
Human Brain Development ◽  
Neuroepithelial Cells

AbstractThe human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we performed single-cell RNA-sequencing across regions of the developing human brain, including the telencephalon, diencephalon, midbrain, hindbrain and cerebellum. We identify nine progenitor populations physically proximal to the telencephalon, suggesting more heterogeneity than previously described, including a highly prevalent mesenchymal-like population that disappears once neurogenesis begins. Comparison of human and mouse progenitor populations at corresponding stages identifies two progenitor clusters that are enriched in the early stages of human cortical development. We also find that organoid systems display low fidelity to neuroepithelial and early radial glia cell types, but improve as neurogenesis progresses. Overall, we provide a comprehensive molecular and spatial atlas of early stages of human brain and cortical development.

Human brain development and its in vitro recapitulation

2019 ◽  
Vol 138 ◽  
pp. 33-42 ◽  
Author(s):  
Yusuke Seto ◽  
Mototsugu Eiraku
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Human Brain Development
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