GASTROPROTECTIVE AND ANTIOXIDANT EFFECTS OF POWDERED LEAVES OF MORINGA OLEIFERA AGAINST EXPERIMENTALLY INDUCED PEPTIC ULCER IN MALE MICE

2021 ◽  
Vol 36 (2) ◽  
pp. 141-148
Author(s):  
N. Latif ◽  
M. A. Naeem ◽  
A. Rashid ◽  
B. Aslam ◽  
M. M. Ashraf
Keyword(s):  
Peptic Ulcer ◽  
Adult Male ◽  
Moringa Oleifera ◽  
Histopathological Examination ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Male Mice ◽  
Healthy Adult Male ◽  
Total Antioxidant ◽  
Antioxidant Effects

Moringa oleifera is used worldwide for its different pharmacological actions. In present study, the gastroprotective and antioxidant effects of M. oleifera were investigated in aspirin induced peptic ulcer in adult male mice. For that purpose, sixty healthy adult male mice were divided equally but randomlyinto 6 groups. Blood samples were drawn at 0 and 7 days of treatment. At the termination of experiment, the mice were slaughtered and stomach tissues were excised for histopathological examination. Statistical differences among treatment groups were determined by Duncan’s Multiple Range test at 5% level of significance. The results suggested that aspirin induced gastric mucosal damage significantly (P<0.05) increased the level of total oxidant status and malondialdehyde, while significantly (P<0.05) decreased catalase and total antioxidant capacity. It was concluded that M. oleifera leaves’ powder at the dose rate of 600 mg/kg is as efficacious as omeprazole by exhibiting gastroprotective and antioxidant effects against aspirin induced gastric damage in mice.

The Antioxidant Effects of Germinating Tartary Buckwheat Vinegar

2014 ◽  
Vol 651-653 ◽  
pp. 305-312 ◽  
Author(s):  
Yun Long Li ◽  
Ting Jun Ma ◽  
Hong Mei Li ◽  
Jun Jun Hu ◽  
Jun Sheng Bian ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Dose Group ◽  
Low Dose ◽  
Positive Control ◽  
Control Model ◽  
Male Mice ◽  
Total Antioxidant ◽  
Antioxidant Effects ◽  
Different Doses

The present study was to evaluated the antioxidant capacity and the effect to the D - galactose senile mice of buckwheat vinegar which maked by sprouting buckwheat, divided healthy Kunming male mice into blank, positive control, model and three dose groups of vinega made by stirring buckwheat randomly. After 6 weeks, it was determined the activity of antioxidant enzyme and malondialdehyde in mice with different doses groups. The results showed that: the stirring buckwheat vinegar exhibited strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 was 0.58*10-2 ) and total antioxidant capacity (210.58 mmolFe2SO4•ml-1 ); the vinegar can droped the level of MDA and improved the activity of SOD in liver of D - galactose senile mice. The low-dose group can improved the activity of SOD in serum. However, for the aging mice, the buckwheat vinegar had no effect on behavior when they were in the new environment, the ability of reduced the activity of TChE in brain and the level of MDA in serum was not significant, at the same time, the activity of GSH-px in the serum couldn't be enhanced.

Protective effects of ethanol extract of a Mexican propolis on indomethacin-induced gastric mucosal damage in mice.

2019 ◽  
Author(s):  
DV Pilar ◽  
VVS Ibran ◽  
RC Mario ◽  
CA Octavio ◽  
MM Canales-Martinez ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Protective Effects

Safety and Tolerance ofLactobacillus reuteriin Healthy Adult Male Subjects

1994 ◽  
Vol 8 (2) ◽  
Author(s):  
B. W. Wolf ◽  
K. A. Garleb ◽  
D. G. Ataya ◽  
I. A. Casas
Keyword(s):  
Adult Male ◽  
Healthy Adult ◽  
Healthy Adult Male ◽  
Male Subjects
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