scholarly journals Immune reconstitution inflammatory syndrome or upgrading Type 1 reaction? Report of two AIDS patients presenting a shifting from borderline lepromatous leprosy to borderline tuberculoid leprosy

2008 ◽  
Vol 79 (4) ◽  
pp. 429-435
Author(s):  
Carolina Talhari ◽  
Luiz Carlos De Lima Ferreira ◽  
José Ribamar Araújo ◽  
Anette Chrusciak Talhari ◽  
Sinésio Talhari
Keyword(s):  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Lepromatous Leprosy ◽  
Aids Patients ◽  
Reaction Report ◽  
Tuberculoid Leprosy ◽  
Inflammatory Syndrome

scholarly journals Type 1 Helper T Cells and FoxP3-positive T Cells in HIV–Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome

2008 ◽  
Vol 178 (10) ◽  
pp. 1083-1089 ◽  
Author(s):  
Graeme Meintjes ◽  
Katalin Andrea Wilkinson ◽  
Molebogeng Xheeda Rangaka ◽  
Keira Skolimowska ◽  
Kerryn van Veen ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Helper T Cells ◽  
Inflammatory Syndrome

scholarly journals Nuclear Factor of Activated T Cells and Cytokines Gene Expression of the T Cells in AIDS Patients with Immune Reconstitution Inflammatory Syndrome during Highly Active Antiretroviral Therapy

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Jia Sun ◽  
Heling Chen ◽  
Yirui Xie ◽  
Junwei Su ◽  
Ying Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
High Expression ◽  
Nuclear Factor ◽  
Aids Patients ◽  
Activated T Cells ◽  
Inflammatory Syndrome

Background. The etiology of immune reconstitution inflammatory syndrome (IRIS) in AIDS patients after the initiation of HAART remains unknown. Several researches indicated that the development of IRIS is associated with the production and variation of cytokines, whose gene expression are closely related to the Ca2+/CN-nuclear factor of activated T cells (NFAT) pathway.Methods. We studied the expression of NFAT isoforms and their major target cytokines genes in peripheral blood CD3+T cells of subjects through fluorescence quantitative PCR and explored the expression changes of these genes before and after HAART.Results. After the initiation of HARRT, NFAT1, IL-6, and IL-8 gene expression showed a reversal trend in the CD3+T cells of the IRIS group and changed from low expression before HARRT to high expression after HARRT. In particular, the relative gene expression of NFAT1 was markedly higher compared with the other three isoforms. The IRIS group also showed higher NFAT4, NFAT2, NFAT1, IL-1β, IL-10, IL-2, IL-18, and TNF-αgene expression than the non-IRIS group.Conclusion. This study suggested that high expression levels of IL-2, IL-6, IL-8, TNF-α, IL-1β, IL-10, IL-12, and IL-18 can predict the risk of IRIS. The increased expression of NFAT1 and NFAT4 may promote the expression of cytokines, such as IL-6, IL-8, and TNF-α, which may promote the occurrence of IRIS.

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