Effects of Separate and Combined Chronic Ingestion of Tramadol and Codeine on Aggressive Behaviour among Female Albino Rats

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
S.K. Balogun ◽  
J. I. Osuh
Keyword(s):  
Aggressive Behaviour ◽  
Albino Rats ◽  
Chronic Ingestion

scholarly journals Effects of Separate and Combined Chronic Ingestion of Codeine and Tramadol on Feeding Behaviour of Female Albino Rats.

2020 ◽  
Vol 6 (7) ◽  
Author(s):  
S.K. Balogun ◽  
J.I. Osuh ◽  
O.O. Onibokun
Keyword(s):  
Body Weight ◽  
Chronic Exposure ◽  
Feeding Behaviour ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Chronic Ingestion ◽  
Mean Differences ◽  
Control And Management ◽  
And Control

Tramadol and codeine are both opioids used for pain control and management but are prone to misuse and abuse despite the various side effects. This study, therefore, examined the effects of chronic exposure to Codeine and Tramadol on feeding behaviour. Twenty-Four (24) Female Albino Rats weighing between 150-200g and 4-6 weeks old, were used. They were divided into 4 experimental groups of Codeine, Tramadol, combined Codeine and Tramadol and Control groups with 6 rats in each group and exposed to 8mg/kg of codeine, 20mg/kg of tramadol, combined 8mg/kg of codeine and 20mg/kg of tramadol, and normal saline for 28 days. Records of the amount of food ingested and the bodyweight of the rats were taken daily for the duration of the experiment. Randomized block ANOVA showed a significant effect of Codeine and Tramadol on feeding behavior (F (3,641) = 25.53, p < 0.001, η2= .11), and body weight (F (3,641) = 76.67, p < 0.001, η2= .26), among the female rats. Female rats in the combined codeine and tramadol group ingested less food (x ̅=33.45), compared to codeine group alone (x ̅=40.71), tramadol group alone (x ̅=39.96) and control group (x ̅=49.38).  Female rats in the combined codeine and tramadol group gained less weight (x ̅=132.67), compared to codeine group alone (x ̅=137.67), tramadol group alone (x ̅=133.33), and control group (x ̅=164.25). The mean differences were significant (p<.001). It was concluded that chronic exposure to tramadol and codeine has effects on feeding behaviour and subsequent body weight.

scholarly journals Effects of Separate and Combined Chronic Ingestion of Codeine and Tramadol on Self Grooming Behavior of Male and Female Albino Rats

2020 ◽  
Vol 9 (3) ◽  
pp. 66
Author(s):  
Shyngle Kolawole Balogun ◽  
Peter Oluwafemi Famakinde ◽  
Deborah Yetunde Adebayo ◽  
Godwin Atue
Keyword(s):  
Albino Rats ◽  
Grooming Behavior ◽  
Male And Female ◽  
Chronic Ingestion

Effects of renovascular hypertension on rat adrenal zona glomerulosa

1978 ◽  
Vol 36 (2) ◽  
pp. 582-583
Author(s):  
G. Mazzocchi ◽  
P. Rebuffat ◽  
C. Robba ◽  
P. Vassanelli ◽  
G. G. Nussdorfer
Keyword(s):  
Renovascular Hypertension ◽  
Left Kidney ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Zona Glomerulosa ◽  
Ultrastructural Changes ◽  
Albino Rats ◽  
Left Renal Artery ◽  
Angiotensin System ◽  
And Control

It is well known that the rat adrenal zona glomerulosa steroidogenic activity is controlled by the renin-angiotensin system. The ultrastructural changes in the rat zona glomerulosa cells induced by renovascular hypertension were described previously, but as far as we are aware no correlated biochemical and morphometric investigations were performed.Twenty adult male albino rats were divided into 2 experimental groups. One group was subjected to restriction of blood flow to the left kidney by the application of a silver clip about the left renal artery. The other group was sham-operated and served as a control. Renovascular hypertension developed in about 10 days: sistolic blood pressure averaged 165 ± 6. 4 mmHg, whereas it was about 110 ± 3. 8 mmHg in the control animals. The hypertensive and control rats were sacrificed 20 days after the operation. The blood was collected and plasma renin activity was determined by radioimmunological methods. The aldosterone concentration was radioimmunologically assayed both in the plasma and in the homogenate of the left capsular adrenal gland.

Further Studies on the Ultrastructure of Harderian Gland in Adult Rats

1974 ◽  
Vol 32 ◽  
pp. 288-289
Author(s):  
Alfredo Feria-Velasco ◽  
Guadalupe Tapia-Arizmendi
Keyword(s):  
Fine Structure ◽  
Domestic Fowl ◽  
Animal Species ◽  
Acinar Cells ◽  
Harderian Gland ◽  
Myoepithelial Cells ◽  
The Other ◽  
Albino Rats ◽  
Adult Rats ◽  
Cell Components

The fine structure of the Harderian gland has been described in some animal species (hamster, rabbit, mouse, domestic fowl and albino rats). There are only two reports in the literature dealing on the ultrastructure of rat Harderian gland in adult animals. In one of them the author describes the myoepithelial cells in methacrylate-embbeded tissue, and the other deals with the maturation of the acinar cells and the formation of the secretory droplets. The aim of the present work is to analize the relationships among the acinar cell components and to describe the two types of cells located at the perifery of the acini.

Cell Fine Structure as Revealed in Dessicator-Dried Resinless Sections

1981 ◽  
Vol 39 ◽  
pp. 622-623
Author(s):  
R. P. Becker ◽  
J. J. Wolosewick ◽  
J. Ross-Stanton
Keyword(s):  
Fine Structure ◽  
Tannic Acid ◽  
Three Dimensional ◽  
Albino Rats ◽  
Cell Organelles ◽  
Vascular Perfusion ◽  
Thin Sections ◽  
Carbon Coated ◽  
Embedding Medium ◽  
Polyethylene Glycol 6000

Methodology has been introduced recently which allows transmission and scanning electron microscopy of cell fine structure in semi-thin sections unencumbered by an embedding medium. Images obtained from these “resinless” sections show a three-dimensional lattice of microtrabeculfee contiguous with cytoskeletal structures and membrane-bounded cell organelles. Visualization of these structures, especially of the matiiDra-nous components, can be facilitated by employing tannic acid in the fixation step and dessicator drying, as reported here.Albino rats were fixed by vascular perfusion with 2% glutaraldehyde or 1.5% depolymerized paraformaldehyde plus 2.5% glutaraldehyde in 0.1M sodium cacodylate (pH 7.4). Tissues were removed and minced in the fixative and stored overnight in fixative containing 4% tannic acid. The tissues were rinsed in buffer (0.2M cacodylate), exposed to 1% buffered osmium tetroxide, dehydrated in ethyl alcohol, and embedded in pure polyethylene glycol-6000 (PEG). Sections were cut on glass knives with a Sorvall MT-1 microtome and mounted onto poly-L-lysine, formvar-carbon coated grids while submerged in a solution of 95% ethanol containing 5% PEG.

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