scholarly journals Comparison of the effects of etomidate, ketamine, sodium thiopental, and midazolam on the mortality of patients with COVID-19 requiring intubation

2021 ◽  
Author(s):  
Abbas Edalatkhah ◽  
Mohammad Reza Kazemi ◽  
Zohreh Akhoundimeybodi ◽  
Seyed Mohsen Seyedhosseini ◽  
Soheila Rostami ◽  
...  
Keyword(s):  
Sodium Thiopental

STUDY OF THE COMBINED INFLUENCE OF SODIUM THIOPENTAL AND DELTA SLEEP-INDUCING PEPTIDE ON ANTIOXIDANT DEFENSE SYSTEM IN RATS

2016 ◽  
pp. 49-52
Author(s):  
A. V. Shvetsov ◽  
E. G. Batotsyrenova ◽  
N. A. Dyuzhikova ◽  
V. A. Kashuro ◽  
N. V. Lapina ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Time Interval ◽  
Sodium Thiopental ◽  
Antioxidant Defense Enzymes ◽  
Delta Sleep ◽  
Thiopental Coma ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Delta Sleep Inducing Peptide

A biochemical investigation was performed into activity of rat antioxidant defense enzymes at different time interval after administration of sodium thiopental and delta-sleep-inducing peptide (DSIP). It was shown that thiopental coma was accompanied by a decreased level of superoxide dismutase ( 6 and 24 h after exposure) and increased level of caspase-3 ( 6 h after exposure) in the rat blood plasma. A pharmacological correction with DSIP induced a decrease of the level of superoxide dismutase ( 6 and 24 h after exposure), glutathione peroxidase and glucose 6-phosphate dehydrogenase (after 6h).

INFLUENCE OF SODIUM THIOPENTAL ON CONSERVATION OF CONDITIONAL REFLEX OF PASSIVE AVOIDANCE IN RATS WITH DIFFERENT NERRVOUS SYSTEM EXCITABILITY

2018 ◽  
pp. 8-11
Author(s):  
A. V. Shvetsov ◽  
A. I. Vaido ◽  
N. A. Dyuzhikova ◽  
A. V. Belskaya ◽  
M. V. Mikhailova ◽  
...  
Keyword(s):  
Nervous System ◽  
Passive Avoidance ◽  
Avoidance Response ◽  
Conditioned Reflex ◽  
Lethal Dose ◽  
Conditional Reflex ◽  
Passive Avoidance Response ◽  
Sodium Thiopental ◽  
Higher Sensitivity

A study of the dynamics of preservation of the conditioned reflex of passive avoidance (passive avoidance response) in rats of two lines with different level of excitability of the nervous system was performed: with a high and low thresholds of excitability as normal and after exposure to sodium thiopental semi-lethal dose. It was shown that a long preservation of the memorable trace under standard conditions and a higher sensitivity to the sodium thiopental action manifest in rats with a high excitability threshold in comparison with low-excitable line of rats.

STUDYING SEDATIVE ACTIVITY OF COMBINED TINCTURE OF MOTHERWORT AND ST JOHN'S-WORT

2021 ◽  
Vol 92 (2) ◽  
pp. 59-64
Author(s):  
O. M. Khishova ◽  
◽  
V. D. Avdachenok ◽  
Keyword(s):  
Quality Indicators ◽  
Lateral Position ◽  
Control Group ◽  
Sodium Thiopental ◽  
Hypnotic Effect ◽  
St John’S Wort ◽  
Percolation Method ◽  
St John's Wort ◽  
Falling Asleep ◽  
Sedative Activity

The paper presents studying sedative activity of the combined tincture of motherwort and St. John's wort. The combined tincture of motherwort and St. John's wort was obtained by percolation method in a ratio 1:10. Standardization of the obtained tincture was carried out with quality indicators: description, content of active ingredients and ethanol, relative density, dry residue. According to all quality indicators, the tincture obtained met the requirements of the State Pharmacopoeia of the Republic of Belarus. Specific sedative activity of the combined tincture of motherwort and St. John's wort was assessed by barbiturates hypnotic effect prolongation (sodium thiopental), by the rate of falling asleep in animals and by animals staying in lateral position in relation to the control group to which sodium thiopental was injected. In the studies carried out it was found that injection of the combined tincture of motherwort and St. John's wort at a dose of 0,1 ml / kg increases sleep by 125,63% and also accelerates the process of falling asleep by 327,75% compared with the separate injection of motherwort and St. John's wort tincture at doses of 0,1 ml/kg. It was shown that the injection of the combined tincture of motherwort and St. John's wort at a dose of 0,1 ml/kg exhibits a potentiated effect and enhances the hypnotic effect of sodium thiopental administered at a dose of 10 mg/kg.

Effect of Sodium Thiopental on Circulatory Response to Positive Pressure Inflation of Lung

1952 ◽  
Vol 4 (8) ◽  
pp. 629-635 ◽  
Author(s):  
H. L. Price ◽  
E. H. Conner ◽  
J. D. Elder ◽  
R. D. Dripps
Keyword(s):  
Positive Pressure ◽  
Sodium Thiopental ◽  
Circulatory Response

Effect of Propofol, Sevoflurane and Desflurane on Systemic Redox Balance

2007 ◽  
Vol 20 (3) ◽  
pp. 585-593 ◽  
Author(s):  
G. Cinnella ◽  
G. Vendemiale ◽  
M. Dambrosio ◽  
G. Serviddio ◽  
P.L. Pugliese ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Antioxidant Properties ◽  
Redox Balance ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Sodium Thiopental ◽  
Blood Samples ◽  
Plasma Antioxidant Capacity ◽  
Trolox Equivalent ◽  
Plasma Antioxidant ◽  
Group D

We studied the effects of Propofol, Desflurane, and Sevoflurane on the systemic redox balance in patients undergoing laparohysterectomy. We measured blood concentration of glutathione (GSH), plasma antioxidant capacity (Trolox Equivalent Antioxidant Capacity-TEAC), and lipid peroxidation products (malondialdehyde (aMDA) and 4-hydroxynonenal (aHNE) protein adducts). Sixty patients were randomly placed into three groups of twenty people each. In Group P anesthesia was induced with Propofol 2 mg/kg and maintained with 12–10–8 mg/kg/min; in Groups S and D anesthesia was induced with 3 mg/kg Sodium Thiopental and maintained with 2% Sevoflurane and 6% Desflurane, respectively. Blood samples were collected prior to induction (T0bas), 60min and 24h postoperatively (T160' and T224 h). In Group P, GSH increased on T160' (p<0.02) and returned to baseline on T24h, while TEAC remained unmodified; in Groups S, GSH and TEAC decreased on T160' (p<0.01 vs. T0bas, p<0.03 vs. T0bas, respectively); in Group D, on T160' there was a slight decrease of GSH and TEAC. The levels of aMDA slightly decreased throughout the study periods in Group P, increased in Group D, and remained stable in Group S. Propofol showed antioxidant properties, while Sevoflurane and Desflurane seemed to shift the redox balance towards oxidation, yet without inducing overt oxidative damage.

STUDY OF THE STATE OF STRESS-IMPLEMENTING SYSTEMS IN ABDOMINAL DELIVERY DEPENDING ON ANESTHETIC TECHNIQUES

2020 ◽  
Vol 73 (11) ◽  
pp. 2378-2385
Author(s):  
Marine A. Georgiyants ◽  
Olena V. Vуsotska ◽  
Nataliia P. Seredenko ◽  
Tatiana V. Chernii ◽  
Hanna N. Strashnenko ◽  
...  
Keyword(s):  
Cesarean Section ◽  
General Anesthesia ◽  
Pregnant Women ◽  
Pain Intensity ◽  
Stress Hormones ◽  
Anesthetic Techniques ◽  
Protective Effects ◽  
Sodium Thiopental ◽  
State Of Stress ◽  
Abdominal Delivery

The aim: Evaluation of stress-protective effects of various anesthetic techniques on Cesarean section (CS). Materials and methods: 127 pregnant women who delivered by cesarean section, were divided into 4 subgroups: 1a (n = 31) – general anesthesia (GA) with ketamine, 1b (n = 31) – GA with sodium thiopental, 2a (n = 31) – spinal anesthesia (SA), 2b (n = 34) – SA with intravenous administration of ondansetron at a dose of 8 mg. The assessment was performed at 5 stages: 1 – initial; 2 – infant extraction; 3 – 6 hours after surgery; 4 – 12 hours after surgery. Results: At stage 2, insulin levels in 1a and 1b subgroups decreased by 23.9% and 34.1%, while in 2a and 2b subgroups there were no significant changes. There was an increase in the levels of cortisol, prolactin and cortisol/insulin ratio at the 2 and 3 stages in the 1a and 1b subgroups. Pain intensity increased by the 3 stage in patients of all groups. It was the highest in the 1a and 1b subgroups. At the 4 stage, pain intensity was reduced in all groups, remaining significantly higher in patients of 1a and 1b subgroups. Conclusions: The dynamics of the content of stress hormones, the pain intensity in patients undergoing CS under SA give reason to consider this method as an optimal and adequate one for protection from surgery stress.

Особливості впливу крововтрати на динаміку поглинально-видільної та глікогенсинтезувальної функції печінки внаслідок краніоскелетної травми

2017 ◽  
Author(s):  
T. A. Zayets ◽  
M. I. Marushchak ◽  
I. Ya. Pidhaina
Keyword(s):  
Glycogen Content ◽  
Closed Head Injury ◽  
Traumatic Shock ◽  
Multiple Organ ◽  
Male Rats ◽  
Absorption Function ◽  
Sodium Thiopental ◽  
Post Traumatic ◽  
And Function ◽  
Selection Of

Introduction. Many scientific researches were described about functional state of a liver as a model of multiple organ dysfunction in severe conditions of experimental injury. Important sensitive markers of liver failure are: absorption function and excretion function of a liver, with its function of synthesizing of glycogen.The aim of the study – to learn the dynamics of absorption and excretion of a liver, with its function of synthesizing of glycogen in response to cranioskeletal injury, combined with blood loss.Methods of the research. The experiments were performed on 54 white nonlinear male rats. In both experimental groups with sodium thiopental anesthesia we modeled a closed head injury according to the method in our own modifications. In addition, by a specially designed device was applied one-off challenge on each thigh, causing a closed fracture of the femur. We determined the duration of the selection of bromsulphalein in bile and glycogen content in the liver.Results and Discussion. The results indicated that under the influence of simulated injuries we observed violations of absorption and excretion of a liver, with its function of synthesizing of glycogen. The largest deviations occurred after 7 days of post-traumatic period. Thus, in terms of additional bleeding violation of the liver was bigger. The reasons were: apparently deepening traumatic shock, the development of hypoxia, systemic response to inflammation.Conclusions. The experimental cranioskeletal injury is accompanied by violation of absorption, excretion and function of synthesizing of glycogen, manifested increasing duration of start and duration of bromsulphalein allocation and reduction of glycogen in the liver tissue, especially at 3 and 7 days post-traumatic period. Additional blood loss is accompanied by an even greater violation of these features since the first day of the experiment. After 3 and 7 days post-traumatic period the beginning and duration of allocation of bromsulphalein are significantly higher and glycogen content – less than in the group of animals with cranioskeletal injury, but without additional bleeding.

scholarly journals The Chemical Stability and Sterility of Sodium Thiopental After Preparation

1998 ◽  
Vol 86 (1) ◽  
pp. 208-213
Author(s):  
J. Larry Haws ◽  
Norman Herman ◽  
Yoshimi Clark ◽  
Robert Bjoraker ◽  
David Jones
Keyword(s):  
Chemical Stability ◽  
Sodium Thiopental
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